TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Article Citation - WoS: 3Citation - Scopus: 5Current Status of Kidney Replacement Therapy in Türkiye: a Summary of 2022 Turkish Society of Nephrology Registry Report(Aves, 2024-04-09) Seyahi, Nurhan; Kocyigit, Ismail; Eren, Necmi; Tonbul, Halil Zeki; Tatar, Erhan; Yilmaz, Zulfukar; Ates, Kenan; Oguz, Ebru GokBackground: Turkish Society of Nephrology registry collects data on hemodialysis, peritoneal dialysis, and transplantation annually. Registry reports are printed every year as a booklet, and this is the 33rd year of registry reports. The registry is in close collaboration with international registries. Methods: In this paper, we summarized data from the 2022 registry report; additionally, we also provided yearly trends of managing end-stage kidney disease. Results: The number of patients on kidney replacement therapy increases; at the end of 2022, 86 665 patients were on kidney replacement therapy. The prevalence and incidence of end-stage kidney disease were 1016.2 and 160.9 per million population, respectively. Diabetes was the most common cause of end-stage kidney disease. Hemodialysis (71.22%) was the most common type of treatment modality, followed by transplantation (24.68%) and peritoneal dialysis (4.1%). Conclusion: End-stage kidney disease is a critical and growing health problem for our country. The renal registry of the Turkish Ssociety of Nephrology is one of the leading tools for providing current and sound data on this public health problem.Article The Relationship Between Daily Carbonhydrate and Fat Intake a Long With Migraine(2021-10-27) Eşkut, Neslihan; Uysal, Armağan; Ataç, Ceyla; Uysal, Hasan Armagan; Uçar, Ceyla AtaçThe pathophysiology of migraine is not fully understood. The trigeminovascular pathway activation, cortical spreading depression, vascular dysfunction, pro-inflammatory and oxidative states, and gut microbiota are investigated. In this study, we aimed to evaluate the relationship between diet and migraine disease characteristics of our patients. This study was conducted with episodic migraine without aura (n:30) and chronic migraine patients (n:30). Demographic data, body mass indexes (BMI), migraine characteristics were recorded from headache diaries. Food consumption were noted Daily from diet diaries. Total calorie intake and carbohydrate and fat amounts were calculated with an internet-based calorie calculator program.The mean age was 40.1±7.83 years in chronic migraine group ( group 1), and 39.1±6.09 years in group 2. The mean BMI of group 1 was significantly higher (respectively; 28.3±3.14, and 24.9±3.29). The mean duration of migraine was found longer in group 1. The mean headache attack duration was 29.9±21.85 hours in group 1, and 29.6±22.4 was in episodic migraine without aura group (group 2). There was no significant difference between both groups in terms of headache attack duration. Average Daily carbohydrate intake is 178.53±44.86 grams in group 1, and 171.42±50.67 grams in group 2. The mean Daily fat intake was 58.01±13.65 grams in group 1 and 56.62±7.51 grams in group 2. No significant difference was found between the groups in terms of Daily calorie, mean Daily fat and, average carbohydrate intake. In our study, we did not find difference in food intake between groups, but BMI of the chronic migraine group were higher. The role of diet on the migraine pathophysiology is still under investigation. An integrative approach to migraine patients by reviewing their diet will help to understand the pathophysiology of migraine, increase the quality of life of patients and prevent unnecessary drug usage.Article Endoscopic Botulinium Toxin-A Application in the Treatment of Obesity: the Effect of Dose and Application Area on Treatment Success(2023) Özsan, İsmail; Tuzun, Ahmet YektaAim: In this study, it was aimed to examine the effect of dose and region on the effectiveness of Endoscopic botulinum toxin A application in the fight against obesity. Materials and Methods: A total of 446 patients who applied to our clinic with the complaint of weight were included in the study. Endoscopic botulinum toxin A was administered at doses of 300 U (n=74), 400 U (n=172) and 500 U (n=200) according to the weight and Body Mass Index (BMI) values of the patients. Patients were divided into three groups in the Preploric, Cardia and Fundus regions, after 125 U of Endoscopic Botulinum toxin A application to each region, and 125 U application to one region. Results: Initial BMI, weight difference, last BMI and BMI differences were statistically significant between patient groups according to dose and area (p=0.000). All BMI differences between paired dose and area groups were statistically significant (p=0.000). BMI difference was significantly correlated with gender (r=0.108; p=0.023), Initial BMI (r=0.266; p=0.000), weight (r=0.219; p=0.000), dose (r=0.834; p=0.000), and area (r=0.200; p=0.000). Effects of initial BMI (B=0.031; p=0.031), dose (B=1.423; p=0.000) and area (B=0.316; p=0.000) on BMI difference were statistically significant. Conclusion: Optimum results are obtained in the application of fundus region with a density of 500 U in total, but at levels or values below this, the results may not be effective. Weight loss with the Endoscopic botulinium toxin-A method with the appropriate dose and area is an effective and usable method in the fight against obesity.Article Investigation of Cyclin-D1 Immunohistochemical Expression in Bladder Urethelial Carcinoma(2023-06-27) Adalı, Yasemen; Ezer, Mehmet; Yılmaz Ertürk, Fatma; Beşeren, Hatice; Ertürk, Fatma YılmazObjective: Cyclin D1 is a protein that is involved in the regulation of the cell cycle and is encoded by the CCND1 gene. There are few studies on Cyclin D1 in the literature, and the results differ in the studies. In this study, the relationship between Cyclin D1 expression and prognostic factors in bladder urothelial carcinomas was investigated. Materials and Methods: Forty-six patients who underwent TUR-M at the Kafkas University Health Research and Application Hospital were included in the study. General information about the cases and pathology reports were obtained from the hospital automation system. Tumor-containing sections were selected from the Hematoxylin and Eosin stained pathology slides, and immunohistochemical staining was performed manually with Cyclin D1 primary antibody on the blocks of the selected slides. Immunostained pathology slides were evaluated under light microscope by scoring 0-4 separately as nuclear and cytoplasmic scores. Results: The age range of the cases was 51-93, and the mean age was 69.2±11.7. Twelve (26.1%) cases were female and 34 (73.9%) were male. It was observed that 29 (63.0%) of the cases were low- grade and 17 (37.0%) were high-grade. Eighteen (39.1%) of the cases were invasive and 28 (60.9%) were noninvasive. In the statistical analyzes, it was noted that invasive tumors had a significantly higher grade compared to non-invasive tumors (pTa) (p= 0.007). Similarly, the presence of lymphovascular invasion in invasive tumors was statistically <0.005 higher than that of in non- invasive tumors. (p=0.001). It was observed that nuclear cyclin D1 expression (p=0.003) was significantly higher in invasive cases. In addition, nuclear cyclinD1 expression was found to be statistically significantly higher in low-grade tumors (p=0.044). Conclusion: As a result of the study, a relationship between Cyclin D1 expression and tumor grade and invasion status was observed in patients with bladder urothelial carcinoma, but studies with larger case series are needed to use Cyclin D1 as a biomarker.Article Tıp Fakültesi Öğrencilerinin Kanıta Dayalı Tıp Farkındalık Düzeyleri(2022-12-15) Arslan, Mehmet; Keskin Arslan, Elif; Küçükerdem, Halime Seda; Çakır, Meryem; Koç, Esra Meltem; Sözmen, Melih Kaan; Pamuk, Gülseren; Keskin-arslan, Elif; Sozmen, Kaan; Kaplan, YusufAmaç: Kanıta dayalı tıp, klinikte hastayla ilgili kararlar alırken hekimin kişisel deneyimlerine, hasta değer ve beklentilerine, var olan kanıtlanmış bilgileri entegre etmesi, bu bilgilerin dikkatli, açık ve mantıklı bir şekilde kullanılmasıdır. Bu çalışmanın amacı, bir tıp fakültesi öğrencilerinin kanıta dayalı tıp ile ilgili farkındalıklarının değerlendirilmesi ve elde edilecek veriler ile öğrencilerin tıp eğitimi süresince kanıta dayalı tıp ile ilgili teorik ve pratik ders içeriğinin belirlenmesine ışık tutmaktır. Yöntem: Çalışmanın evrenini, tıp fakültesi dönem 3, 4, 5 ve 6 öğrencileri oluşturmaktadır. Çalışmada kullanılmak üzere araştırmacılar tarafından geliştirilmiş, toplamda 23 sorudan oluşan anket formları hazırlandı ve istatistiksel değerlendirmede ki-kare testi ve Fisher’s exact test kullanıldı. Bulgular: Araştırmaya 163 öğrenci dâhil edildi. Katılımcıların %43,6’sı kanıta dayalı tıp eğitimi almıştı ve katılımcıların %92’si kanıta dayalı tıbbı duymuştu. Katılımcıların %78,5’i kanıta dayalı tıp ile ilgili daha fazla bilgi edinmek istiyordu. Tıbbi bilgi edinmek için katılımcıların %93,9’u ders notları, %75,5’i ders kitabı kullanıyordu ve veri tabanlarını bilme durumları açısından %81’i Pubmed, %58,3’ü Google Akademik, %55,3’ü Medline, %35’i UpToDate’i biliyordu. Sonuç: Mevcut kanıta dayalı tıp kaynaklarına ilişkin farkındalığın artırılmasına ve bunlaraerişim sağlanmasına gereksinim vardır. Kanıta dayalı tıp eğitimi için üniversitelerde uygun müfredat hazırlanmalı ve kanıta dayalı tıbbın önündeki engeller ortadan kaldırılmalıdır.Article Burnout and Job Satisfaction Among Family Physician(2022-06-20) Gökdemir, Özden; Güldal, Azize Dilek; Batur, Ülkü Bulut; Dağbağlı, Gamze; Aygün, Olgu; Guldal, DilekAim: Burnout syndrome is a major problem, especially among health care workers. The higher the sense of individual skills and achievement, the lower the likelihood of burnout syndrome. The objective of the study is to measure the level of burnout and job satisfaction of family physicians. Methods: Both data of the Family Physicians (FPs) who are working in rural and urban has been included in the study. The study is designed to measure their level of burnout and job satisfaction using the Maslach Burnout Inventory, Minnesota Work Satisfaction Questionnaire. Their relationship with the working area and other factors is also analyzed. Results: Maslach depersonalization subscale was found to be significantly higher in those who lived alone, those who defined their location as rural, and those who did not participate in continuing medical education (CME) (p=0.02, p=0.01, p=0.03). While Maslach personal achievement score was low in those who define their location as rural (p=0.01) it was found to be higher in women and those who did not participate in CME (p=0.02, p=0.03). In addition, as age increases, Maslach emotional burnout and depersonalization scores decrease and personal success scores increase (r =-0.169, -0.205, 0.163 and p=0.00, p=0.00, p=0.00). Conclusions: Emotional and total burnout scores decreased with age, and that attending CME increased personal achievement. CME could be a beneficial tool not only to support FPs but also to prevent burnout.Article Investigation of Neuraminidase 1 Gene Association in Henoch-Schönlein Purpura (hsp) With Renal Involvement(Pamukkale University, 2022-07-01) Yılmaz, N.B.; Ertan, P.; Yüksel, S.; Neşe, N.; Dinç Horasan, Gönül; Berdeli, A.H.; Horasan, Gönül Dinç; Bahçeci, Nezihe BilgePurpose: HSP is a common small vessel vasculitis. It is the most common cause of non-thrombocytopenic purpura in childhood. The role of genes in etiopathogenesis of the disease, which has not yet been clearly elucidated, is being emphasized. Many genes called sialidases are being studied and is thought that the NEU1 gene may be particularly important in the etiopathogenesis of HSP. The aim of this study is to investigate the role of the NEU1 gene in the etiopathogenesis of HSP and its relation to renal involvement. Materials and methods: Fifty patients followed in the Celal Bayar University Hafsa Sultan Hospital Pediatric Nephrology Department, with the diagnosis of HSP renal involvement were included into the study. For the control group, age and gender matched 50 cases were accepted among the outpatients admitted to Pediatric Department without any chronic diseases. NEU1 gene mutation analysis was performed in blood samples of both patient and control groups by using the Sanger DNA sequencing method. Results: NEU1 genetic mutation was not detected in any HSP patient with renal involvement and control group. Conclusion: In our study, the NEU 1 gene was not found to be associated with HSP nephritis. No changes were detected in the investigated regions of the NEU1 gene. © 2022, Pamukkale University. All rights reserved.Article Knowledge, Attitudes, and Opinions of Hepatitis B Virus Carrier Male Patients About the Disease(Doc Design Informatics Co Ltd, 2022-09-28) Digrak, Ebru; Tezel, AyferObjectives: The study was conducted to evaluate the knowledge, attitudes, and opinions of male patients infected with the hepatitis B virus about their disease. Methods: This descriptive study was conducted in a military hospital in Ankara between July 2016 - July 2017. The study population consisted of 244 male patients admitted to the Infectious Diseases Clinic of the hospital within one year. No sample selection was made, and 208 patients accepted to participate were included in the study. The research data were collected by a questionnaire form consisting of 28 questions prepared by the researchers in line with the literature. For statistical analysis, IBM SPSS Statistics for Windows. Version 22.0 program was used. Results: Of the patients, 86.5% were single, 50% were primary school graduates, 65.4% were self-employed, and their mean age was 22.67 +/- 2.9. According to the data, 53.4% of the patients were HBeAg-negative, and 46.6% were HBeAg-positive chronic hepatitis B patients. Healthcare personnel was the information source for 51.9% of the patients, and 80.8% felt the need to get more information about their disease. 88.4% of the patients stated that hepatitis B disease could be transmitted through the bloodstream, and 80.7% of them stated that being vaccinated prevented them from being sick. 86.5% of the patients stated that the purpose of the treatment of hepatitis B disease was to prevent the progression of the disease. Conclusions: According to the study's results, we determined that the patients' knowledge and attitudes about their diseases were insufficient.Article Birinci Basamakta Çalışan Hekimlerin Dinlenme Hakkı Bağlamında Aile Hekimliğinde Nöbet Uygulaması(2014) Şişli, ZeynepBu çalışmanın amacı, aile hekimlerine nöbet yükümlülüğügetiren düzenlemelerin, çalışma süreleri ve dinlenme hakkıile ilişkisi açısından irdelenmesidir. Yaşam hakkının en temel bileşeni olan sağlığın korunmasında, çalışanlar açısındandinlenme önemli bir ihtiyaçtır. Dinlenme, bağımlı çalışanlarınçalışma sürelerinin sınırlandırılması ile sağlanabilecek birhaktır. Dinlenme hakkı, çalışma süresinin sınırlandırılması mü cadelesi sonucu uluslararası ve ulusal hukukta düzenlenmiştir.Aile hekimlerine getirilen nöbet yükümlülüğü, haftalık vegünlük en fazla çalışma sürelerine ilişkin düzenlemelerışığında dinlenme hakkına etkisi açısından değerlendirilmiştir.Avrupa Çalışma Süresi Yönergesi (2003/88/EC) hükümleriniyorumlayan Avrupa Adalet Divanı kararları, hekimlerin sağlıkkuruluşunda bulundukları tüm nöbet süresinin haftalık çalışmasüresinden sayılması gerektiği yolundadır. Uzun çalışmasüreleri, karşılaştırmalı ülke örneklerinde araştırmalarlabelirlendiği üzere, hekimlerin sağlıklarını olumsuz etkilemekte ve mesleki hata endişesine yol açmaktadır. Avrupa ülkelerinde sağlık hizmetlerinin, Çalışma Süresi Yönergesi ve Avrupa Adalet Divanı kararlarına uygun olarak, en fazla haftalıkçalışma süresini aşmayacak şekilde düzenlenmesi yolundaeleştiri ve çabalar sürmektedir. Türkiyede ise aile hekimlerinin haftalık çalışma süreleri en az 40 saat olarak belirlenmişiken, ayrıca en fazla 30 saat nöbet yükümlülüğü düzenlenerek, haftalık çalışma süresinin en az 70 saat olmasının önüaçılmaktadır. Bu çerçevede, teorik kaynakların taranması yöntemi ile yapılan bu çalışmada, Türkiyede aile hekimleri içinöngörülen nöbet uygulamasının, dinlenme haklarını ihlal edicinitelikte olduğu sonucuna varılmaktadır.Article Serum Magnesium Levels in Patients With the Necrotizing and Edematous Types of Acute Pancreatitis With and Without Hypocalcemia(2017) Ersil Soysal, Dilek; Dere, Yelda; Karakuş, Volkan; Koç, Emrah; Alper, Emrah; Pekdiker, Mete; Şavklıyıldız, Adem; Soysal, Dilek ErsilAmaç: Nekrotizan ve ödematöz tip akut pankreatitli, hipokalsemisi olan ve olmayan hastaların serum magnezyum düzeylerinin hastalık ile ilişkisini incelemeyi amaçladık.Yöntem: Akut pankreatit için revize edilmiş Atlanta kriterlerini karşılayan 114 hastanın hastane kayıtlarından geriye dönük olarak serum magnezyum, kalsiyum, albumin, C-reaktif protein düzeyleri ile lökosit ve trombosit sayıları değerlendirildi.Bulgular: Yaş ortalaması 58,9±15 yıldı. Serum magnezyum, kalsiyum ve albumin düzeyleri nekrotizan tip akut pankreatitli hastalarımızda ödematöz tipteki akut pankreatitli hastalarımıza göre anlamlı derecede düşüktü. Sırasıyla (1,85±0,6 mg/dL vb. 2,12±0,26 mg/dL; p<0,001, 8,37±0,51 mg/dL vb. 8,86±0,59 mg/dL; p<0,001 ve 3,34 g/dL±0,67 g/dL vb. 3,75±0,46 g/dL; p=0,003). Tüm hasta grubunda hipokalsemi saptananlarda saptanmayanlara göre serum magnezyum düzeyleri düşük, serum CRP düzeyleri ve lökosit sayıları yüksek bulundu. Sırasıyla (p<0,001; p=0,002 ve p=0,002). Hastalık tipine göre yapılan değerlendirmede, ödematöz tip akut pankreatitli hastalarda ileri yaşın 1,047-kat (CI: 1,006-1,089; p=0,025), normal düzeylerdeki serum magezyumun 45,4-kat (CI: 3,548-582,336; p=0,003), nekrotizan tip akut pankreatitli hastalarda yüksek serum CRP düzeylerinin 1,082-kat (CI: 1,017-1,157; p=0,013) daha fazla görüldüğü saptandı. Hastalık şiddeti kontrol altına alındıktan sonra serum magnezyum ile albumin düzeylerinin orta düzeyde (r=0,32; p<0,001) ilişkili olduğu saptandı.Sonuç: Nekrotizan tip akut pankreatitli ve hipokalsemisi olan hastalarımızda serum magnezyum düzeyleri düşük bulunsa da akut pankreatitte hipomagnezeminin hastalık şiddeti ile ilişkisi bulunamadı.