Eroğlu, Seçkin

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Profile URL
https://hdl.handle.net/20.500.14365/7319
Name Variants
Eroglu, Seckin
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Email Address
seckin.eroglu@ieu.edu.tr
Main Affiliation
05.08. Genetics and Bioengineering
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Former Staff
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ORCID ID
0000-0002-9494-7080
Scopus Author ID
39061245500
Turkish CoHE Profile ID
F495982FFBB1097A
Google Scholar ID
6ErOs8kAAAAJ
WoS Researcher ID
DVQ-5345-2022

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9

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13

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DECENT WORK AND ECONOMIC GROWTH
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17

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PEACE, JUSTICE AND STRONG INSTITUTIONS
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GOOD HEALTH AND WELL-BEING
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21

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Scholarly Output

6

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WoS Citation Count

194

Scopus Citation Count

221

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4

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WoS Citations per Publication

32.33

Scopus Citations per Publication

36.83

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3

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JournalCount
Bıometals2
Frontıers in Plant Scıence2
Membrane Transport in Plants1
Plant Physıology1
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Now showing 1 - 6 of 6
  • Thumbnail Image
    Review Article
    Citation - WoS: 3
    Citation - Scopus: 5
    Metal Transport in the Developing Plant Seed
    (Academic Press Ltd-Elsevier Science Ltd, 2018) Eroglu, Seckin
    Healthy plant growth depends on a balanced metal homeostasis at the organ, tissue and sub-cellular levels, which is mediated principally by plasma and vacuolar membrane metal transporters. The genetic bases of metal acquisition in developing seeds has long remained poorly understood. Recent technical advances have helped circumvent the difficulties of conducting metal nutrient research on the extremely small seeds of Arabidopsis thaliana. The review presents recent advances in our understanding of seed metal homeostasis focussing on this model plant. Metals are loaded from phloem to the seed coat and must pass through the endosperm to reach the embryo. The embryo comprises several apoplastic and symplastic pathways that strictly depend on the changing physiology of the developing seed organs. Metals that reach the developing embryo fuel immediate cellular processes or accumulate in vacuoles to support forthcoming germination. In the mature embryo, metal distribution is homogeneous, with the exception of iron and manganese which localize to distinct cell layers. These metal localizations are strictly dependent on expression of specific tonoplast transporters, with putative functions that go beyond the storage of metals. Accumulating evidence indicates that they can control the timing of metal entry into the embryo.
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    Article
    Citation - WoS: 92
    Citation - Scopus: 107
    Metal Tolerance Protein 8 Mediates Manganese Homeostasis and Iron Reallocation During Seed Development and Germination
    (Oxford Univ Press Inc, 2017) Eroglu, Seckin; Giehl, Ricardo F. H.; Meier, Bastian; Takahashi, Michiko; Terada, Yasuko; Ignatyev, Konstantin; Andresen, Elisa
    Metal accumulation in seeds is a prerequisite for germination and establishment of plants but also for micronutrient delivery to humans. To investigate metal transport processes and their interactions in seeds, we focused on METAL TOLERANCE PROTEIN8 (MTP8), a tonoplast transporter of the manganese (Mn) subclade of cation diffusion facilitators, which in Arabidopsis (Arabidopsis thaliana) is expressed in embryos of seeds. The x-ray fluorescence imaging showed that expression of MTP8 was responsible for Mn localization in subepidermal cells on the abaxial side of the cotyledons and in cortical cells of the hypocotyl. Accordingly, under low Mn availability, MTP8 increased seed stores of Mn, required for efficient seed germination. In mutant embryos lacking expression of VACUOLAR IRON TRANSPORTER1 (VIT1), MTP8 built up iron (Fe) hotspots in MTP8-expressing cells types, suggesting that MTP8 transports Fe in addition to Mn. In mtp8 vit1 double mutant seeds, Mn and Fe were distributed in all cell types of the embryo. An Fe transport function of MTP8 was confirmed by its ability to complement Fe hypersensitivity of a yeast mutant defective in vacuolar Fe transport. Imbibing mtp8-1 mutant seeds in the presence of Mn or subjecting seeds to wet-dry cycles showed that MTP8 conferred Mn tolerance. During germination, MTP8 promoted reallocation of Fe from the vasculature. These results indicate that cell type-specific accumulation of Mn and Fe in seeds depends on MTP8 and that this transporter plays an important role in the generation of seed metal stores as well as for metal homeostasis and germination efficiency under challenging environmental conditions.
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    Article
    Citation - WoS: 17
    Citation - Scopus: 15
    The Conservation of Vit1-Dependent Iron Distribution in Seeds
    (Frontiers Media Sa, 2019) Eroglu, Seckin; Karaca, Nur; Vogel-Mikus, Katarina; Kavcic, Anja; Filiz, Ertugrul; Tanyolac, Bahattin
    One third of people suffer from anemia, with iron (Fe) deficiency being the most common reason. The human diet includes seeds of staple crops, which contain Fe that is poorly bioavailable. One reason for low bioavailability is that these seeds store Fe in cellular compartments that also contain antinutrients, such as phytate. Thus, several studies have focused on decreasing phytate concentrations. In theory, as an alternative approach, Fe reserves might be directed to cellular compartments that are free of phytate, such as plastids. However, it is not known if seed plastid can represent a major Fe storage compartment in nature. To discover distinct types of Fe storage in nature, we investigated metal localizations in the seeds of more than twenty species using histochemical or X-ray based techniques. Results showed that in Rosids, the largest clade of eudicots, Fe reserves were primarily confined to the embryo of the seeds. Furthermore, inside the embryos, Fe accumulated specifically in the endodermal cell layer, a well-known feature that is mediated by VACUOLAR IRON TRANSPORTER1 (VIT1) in model plant Arabidopsis thaliana. In rice, Fe enrichment is lost around the provasculature in the mutants of VIT1 orthologs. Finally, in Carica papaya, Fe accumulated in numerous organelles resembling plastids; however, these organelles accumulated reserve proteins but not ferritin, failing to prove to be plastids. By investigating Fe distribution in distinct plant lineages, this study failed to discover distinct Fe storage patterns that can be useful for biofortification. However, it revealed Fe enrichment is widely conserved in the endodermal cell layer in a VIT1-dependent manner in the plant kingdom.
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    Correction
    The Conservation of Vit1-Dependent Iron Distribution in Seeds (vol 10, 907, 2019)
    (Frontiers Media Sa, 2020) Eroglu, Seckin; Karaca, Nur; Vogel-Mikus, Katarina; Kavcic, Anja; Filiz, Ertugrul; Tanyolac, Bahattin
    [Abstract Not Available]
  • Thumbnail Image
    Article
    Citation - WoS: 11
    Citation - Scopus: 10
    Genome-Wide Analysis of Gene Expression Profiling Revealed That Cop9 Signalosome Is Essential for Correct Expression of Fe Homeostasis Genes in Arabidopsis
    (Springer, 2017) Eroglu, Seckin; Aksoy, Emre
    In plant cells, either excess or insufficient iron (Fe) concentration triggers stress responses, therefore it is strictly controlled. Proteasome-mediated degradation through ubiquitination of Fe homeostasis proteins has just become the focus of research in recent years. Deactivating ubiquitin ligases, COP9 signalosome has a central importance in the translational control of various stress responses. The aim of the study was to investigate COP9 signalosome in Fe deficiency response of Strategy I plants. In silico analysis of a set of Fe-deficiency-responsive genes was conducted against the transcriptome of Arabidopsis csn mutant lines using Genevestigator software. Induced and suppressed genes were clustered in a hierarchical way and gene ontology enrichment categories were identified. In wild-type Arabidopsis, CSN genes did not respond to iron deficiency. In csn mutant lines, under Fe-sufficient conditions, hundreds of Fe-deficiency-responsive genes were misregulated. Among the ones previously characterized for their physiological roles under Fe deficiency IRT1, NAS4, BTS, NRAMP1 were down-regulated while AHA2, MTP8, FRD3 were up-regulated. Unexpectedly, from those which were regulated in opposite ways, some had been repeatedly shown to be tightly co-regulated by the same transcription factor, FIT. Two proteins from DELLA family, which were reported to interact with FIT to repress its downstream, were found to be strikingly repressed in csn mutants. Overall, the study underlined that the absence of a functional CSN greatly impacted the regulation of Fe homeostasis-related genes, in a manner which cannot be explained simply by the induction of the master transcription factor, FIT. Correct expression of Fe deficiency-responsive genes requires an intact COP9 signalosome in Arabidopsis.
  • Thumbnail Image
    Article
    Citation - WoS: 71
    Citation - Scopus: 84
    Genome-Wide Exploration of Metal Tolerance Protein (mtp) Genes in Common Wheat (triticum Aestivum): Insights Into Metal Homeostasis and Biofortification
    (Springer, 2017) Vatansever, Recep; Filiz, Ertugrul; Eroglu, Seckin
    Metal transport process in plants is a determinant of quality and quantity of the harvest. Although it is among the most important of staple crops, knowledge about genes that encode for membrane-bound metal transporters is scarce in wheat. Metal tolerance proteins (MTPs) are involved in trace metal homeostasis at the sub-cellular level, usually by providing metal efflux out of the cytosol. Here, by using various bioinformatics approaches, genes that encode for MTPs in the hexaploid wheat genome (Triticum aestivum, abbreviated as Ta) were identified and characterized. Based on the comparison with known rice MTPs, the wheat genome contained 20 MTP sequences; named as TaMTP1-8A, B and D. All TaMTPs contained a cation diffusion facilitator (CDF) family domain and most members harbored a zinc transporter dimerization domain. Based on motif, phylogeny and alignment analysis, A, B and D genomes of TaMTP3-7 sequences demonstrated higher homology compared to TaMTP1, 2 and 8. With reference to their rice orthologs, TaMTP1s and TaMTP8s belonged to Zn-CDFs, TaMTP2s to Fe/Zn-CDFs and TaMTP3-7s to Mn-CDFs. Upstream regions of TaMTP genes included diverse cis-regulatory motifs, indicating regulation by developmental stage, tissue type and stresses. A scan of the coding sequences of 20 TaMTPs against published miRNAs predicted a total of 14 potential miRNAs, mainly targeting the members of most diverged groups. Expression analysis showed that several TaMTPs were temporally and spatially regulated during the developmental time-course. In grains, MTPs were preferentially expressed in the aleurone layer, which is known as a reservoir for high concentrations of iron and zinc. The work identified and characterized metal tolerance proteins in common wheat and revealed a potential involvement of MTPs in providing a sink for trace element storage in wheat grains.