Gökçü, Mehmet

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https://hdl.handle.net/20.500.14365/6950
Name Variants
Gokcu, Mehmet
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Email Address
mehmet.gokcu@ieu.edu.tr
Main Affiliation
09.04. Surgical Sciences
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Current Staff
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ORCID ID
0000-0002-3187-2317
Scopus Author ID
6504303111
Turkish CoHE Profile ID
4210E545369D6E02
Google Scholar ID
UmVHIhMAAAAJ
WoS Researcher ID
V-6649-2017

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4

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Akdeniz Tıp Dergisi1
Annals of Saudi Medicine1
International Journal of Gynecology & Obstetrics1
Revista Da Associacao Medica Brasileira1
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  • Thumbnail Image
    Article
    Citation - WoS: 1
    Citation - Scopus: 2
    The Role of Endocervical Curettage in the Diagnosis of Cervical Intraepithelial Neoplasia in Human Papillomavirus Positive Patients
    (K faisal spec hosp res centre, 2024) Gülhan, İbrahim; Özdemir, Raziye; İleri, Alper; İleri, Hande; Özcan, Sena; Öztürk, Ayse Betü; Gökçü, Mehmet
    BACKGROUND: The role of endocervical curettage (ECC) in the diagnosis of cervical intraepithelial neoplasia (CIN) is a controversial topic. OBJECTIVES: Investigate the role of ECC in the diagnosis of CIN in human papillomavirus (HPV) positive patients. DESIGN: Retrospective SETTING: A tertiary training and research hospital PATIENTS AND METHODS: This study included patients who were referred for colposcopy between 2018-2022 because of abnormal screening results. ECC results, age, cytology, HPV status, and colposcopic impression of the patients were extracted from the medical records. Multinomial logistic regression analyses were performed to identify factors that could predict CIN on ECC. MAIN OUTCOME AND MEASURES: The likelihood of high-grade squamous intraepithelial lesions (HSIL) in ECC in patients with cervical biopsy results of normal and low-grade squamous intraepithelial lesion (LSIL). SAMPLE SIZE: 2895 women RESULTS: In patients with normal and LSIL cervical biopsy results, HSILs were detected in 6.7% of ECC results. There was no difference in the detection rates of CIN in ECC among groups with smear results negative for intraepithelial lesions or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US), and LSIL. The likelihood of HSIL being observed in ECC was 2.2 times higher in patients with HPV16. The probability of LSIL disanois was 2.3 times higher in women aged 50-59 years and 2.8 times higher in women >= 60 years compared to the reference group of <30 years. The probability of LSIL was 2.3 and HSIL by ECC was 2.2 times higher in both age categories (P<.012 P <.012 and P =.032, respectively) than the reference group of <30 years. CONCLUSION: Regardless of colposcopic findings, ECC should be performed in patients with smear results of NILM who are positive for HPV16, in patients with smear results of ASC-US and LSIL who are positive for any oncogenic type of HPV and in patients 50 and above with any result of smear or any oncogenic HPV type. LIMITATIONS: We did not have the components of the HPV types in mixed groups.
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    Article
    Citation - WoS: 2
    Citation - Scopus: 2
    The Clinical Significance of Lymphovascular Space Invasion in Patients With Low-Risk Endometrial Cancer
    (Assoc Medica Brasileira, 2023) Cakir, Lker; Gulseren, Varol; Büyüktalancı, Emin; Emiralioğlu Çakır, Zübeyde; Özer, Mehmet; Ata, Can; Sancı, Muzaffer; Gökçü, Mehmet
    OBJECTIVE: The aim of this study was to assess the effect of lymphovascular space invasion on recurrence and disease-free survival in patients with low-risk endometrial cancer.METHODS: The study included patients with stage 1A, grade 1-2 endometrioid endometrial cancer who underwent a total hysterectomy and bilateral salpingo-oophorectomy with pelvic lymphadenectomy. Independent prognostic predictors of endometrial cancer recurrence were assessed using the Cox regression model. Binary logistic regression analysis was used to identify the predictors of distant recurrence. Kaplan-Meier analysis was used to describe survival curves, and the log-rank test was used to compare the differences in survival curves.RESULTS: A total of 189 patients met the inclusion criteria, of whom 24 (12.7%) had lymphovascular space invasion. The median follow-up time was 60 (3-137) months. Distant recurrence was present in 11 of 22 patients who developed recurrence. Kaplan-Meier survival analysis showed that the 5-year disease-free survival rates of patients with lymphovascular space invasion(+) and lymphovascular space invasion(-) were 62.5 and 91.9%, respectively, which were significantly lower (p<0.001). In multivariate Cox regression analysis, the presence of lymphovascular space invasion (p<0.001) and age & GE;60 years (p=0.017) remained as prognostic factors for reduced disease-free survival. In binary logistic regression analysis, only lymphovascular space invasion (adjusted OR=13, 95%CI=1.456-116.092, p=0.022) was a prognostic factor for distant recurrence.CONCLUSION: lymphovascular space invasion is a prognostic risk factor for recurrence and distant metastasis and also a predictor of poorer disease-free survival outcomes in low-risk endometrial cancer.
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    Article
    Recurrence and Characteristics of Endometrial Cancer in Elderly Patients
    (2024) Gülseren, Varol; Çakır, İlker; Kuru, Oğuzhan; Gökçü, Mehmet; Özcan, Aykut; Sancı, Muzaffer; Emiralioğlu Çakı, Zübeyde
    Objective: This study evaluated the treatment options of patients of advanced age (≥70 years) with recurrence, and survival results were analyzed. Material and Methods: The data of patients diagnosed with endometrial cancer (EC) in the Gynecological Oncology Clinic between 2001 and 2020 were evaluated retrospectively. Seventy-six cases with advanced age and relapse were evaluated. Patients who underwent hysterectomy surgery in our center and continued their follow- up regularly were included in the study. Results: The mean age at the time of recurrence was 74.6 ± 3.9 years. The endometrioid type, seen in half of the patients, was the most common histological type. Pelvic paraaortic lymph node (LN) sampling/dissection was performed in 84.2% of the patients. Deep myometrial invasion was detected in 56 (73.7%) patients, and LVSI was found in 42 (56.8%) patients. The mean time to recurrence was found to be 25.1 ± 17.8 months. Total survival times were calculated as 47.2 ± 28.2 months. The five-year overall survival (OS) rate was analyzed as 35.7%. The most common site of recurrence was lung, and isolated lung recurrence was seen in 14 (18.5%) patients. There was no significant difference for OS among patients with pelvic recurrence and extra-pelvic/multiple recurrences (p= 0.723). Conclusion: Survival outcomes in recurrences are worse in advanced- age endometrial cancer patients. This may be due to more limited treatment options for recurrence due to additional internal problems.
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    Article
    Human Papillomavirus Positivity and Cervical Intraepithelial Lesion in Cervical Biopsy and Endocervical Curettage in Women Younger Than 30 Years
    (Wiley, 2025) Gulhan, Ibrahim; Orun, Huseyin; Yanigli, Gulsen; Cagiran, Rumeysa Nur; Inan, Abdurrahman Hamdi; Bozkurt, Korkut; Ozeren, Mehmet
    Objectives: Assess high-risk human papillomavirus (HPV) prevalence and high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia (HSIL/CIN) grade 2+ detection by cervical biopsy and endocervical curettage (ECC) in women younger than 30years. Methods: We retrospectively analyzed medical records from January 2016 to June 2024 at a tertiary hospital. All women aged 21years and older who underwent HPV and Papanicolaou testing, plus those younger than 30years referred for colposcopy, were included. Data on age, HPV status, cytology, colposcopy-directed biopsy, and ECC findings were extracted. The primary outcome was HSIL/CIN 2+ incidence on pathology. Results: Among 57 381 women, high-risk HPV prevalence was 14.3% overall: 36.8% in those aged 21-24years, 24.0% in those aged 25-29years, and 12.7% in those 30years and older. Of 735 women younger than 30years, 291 were managed by follow-up decision and 444 underwent biopsy/ECC; follow-up decision was more common in women aged 21-24years versus those 25-29 years (49% vs. 35.8%). Among the 444 women who underwent biopsy, HSIL/CIN 2+ and HSIL/CIN 3+ occurred in 37.8% and 14.6%, respectively, with similar HSIL/CIN 3+ rates in those aged 21-24years versus those 25-29years (16.8% vs. 13.9%). In 173 women with benign cytology, 30.1% had HSIL/CIN 2+ on pathology. The number needed to screen for HSIL was approximately 2-3 after co-testing versus approximately 40 with Papanicolaou testing alone. In addition, Papanicolaou test alone demonstrated poor agreement with biopsy/ECC results (low Cohen kappa), confirming its inadequate performance. Two cases of cervical cancers were diagnosed at ages 22 and 29years. Conclusions: Similar high-grade lesion rates in women aged 21-24years and those 25-29years support initiating cervical cancer screening at age 21years. Given the substantial HSIL detection despite benign cytology, co-testing with Papanicolaou and HPV testing is recommended in this age group.