Uysal, Armağan
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Uysal, Hasan Armağan
Uysal, Armagan
Uysal, Armagan
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h.uysal@ieu.edu.tr
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09.02. Internal Sciences
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| Journal | Count |
|---|---|
| Advances in Clinical and Experimental Medicine | 1 |
| Journal of Clinical Medicine | 1 |
| Meandros Medical and Dental Journal | 1 |
| Medical Journal of Bakirkoy | 1 |
| Namık Kemal Tıp Dergisi | 1 |
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Article Citation - WoS: 1Citation - Scopus: 1Comparison of Facial Palsy Cases Before and During the Pandemic Coronavirus Disease-2019(Galenos Publ House, 2023) Uysal, Hasan Armağan; Güllüoğlu, HalilObjective: The pandemic coronavirus disease-2019 (COVID-19) is caused by a novel type of coronavirus named severe acute respiratory syndrome coronavirus-2 and is rapidly spreading all over the world. In addition to various neurological symptoms, acute facial palsy was diagnosed as the main neurological symptom in some COVID-19 patients. The current study aimed to analyze the variation and any possible association in the case numbers or medical symptoms of patients with facial palsy before and during the COVID-19 pandemic.Methods: The clinical files of patients who were diagnosed with facial palsy in the Neurology Department of Medicalpoint Hospital, University of Economics Faculty of Medicine, Izmir were retrospectively investigated. To compare the facial palsy cases according to different periods, two patient groups were formed: before the COVID-19 pandemic and during the COVID-19 pandemic. The pandemic group was further divided into two subgroups as COVID-19-positive and COVID-19-negative patients to compare the effects of COVID-19 on facial palsy.Results: During the specified COVID-19 period (May 2020-January 2021) of the study, 38 patients were admitted to the hospital for facial palsy; 34 facial palsy patients were admitted in the same calendar period as the two previous years (May 2018-January 2019). There was no significant difference in the frequency of facial palsy between these two time periods. There were significant differences between before and during the COVID-19 pandemic groups regarding response to cortisone therapy (p<0.001), facial palsy grade (p<0.001), electromyography findings (p=0.005), denervation (p<0.001), and 6 months recovery (p<0.001) data. There were also significant differences between the COVID-19-positive and COVID-19-negative subgroups regarding response to cortisone therapy (p=0.015) and facial palsy grade (p=0.001).Conclusion: The current study findings support the possible association between the severity of the clinical course of facial palsy and COVID-19. Further studies are needed to prove a direct association between facial palsy and COVID-19.Article Citation - WoS: 1Citation - Scopus: 2Contralateral Facial Innervation in Healthy Subjects and in Patients With Peripheral Facial Palsy(MDPI, 2024) Güllüoğlu, Halil; Uysal, Hasan Armağan; Uludağ, BurhanettinBackground: We aimed to investigate the extent of the response of the orbicularis oris muscle to stimulation of the contralateral facial nerve both in patients with peripheral facial palsy (PFP) and in healthy subjects. Methods: EMG was performed at 2-6 weeks after the onset of PFP in the patient group and at any time in the healthy control group. We performed nerve conduction testing, electroneurography, and surface and needle EMG. Results: A total of 276 participants (patients/healthy controls: 218/58) were analyzed. The extent of the response of the contralateral orbicularis oris muscles to facial nerve stimulation was higher in healthy controls compared to that in the affected group. The response of the contralateral orbicularis oris muscles to stimulation of the paralyzed facial nerve was more extensive in those patients to whom glucocorticoid or physical therapy had been given. Cross-facial innervation in the orbicularis oris muscle extended up to 1.5 cm in one-third of healthy controls and was higher than that in those with PFP. Glucocorticoid or physical therapy seemed to improve cross-innervation in facial palsy. Conclusions: Our findings suggest that the stimulus leading to the contralateral muscular response is mediated through crossing axons rather than muscular fibers.Article Citation - Scopus: 1Ocular Flutter-Myoclonus-Ataxia Syndrome After mRNA BNT162b2 COVID-19 Vaccine: A Case Report(Turkish Neuropsychiatric Society, 2023) Poyraz, T.; Varol, A.; Uysal, ArmağanOcular flutter (OF) is a rare oculomotor syndrome. The most common etiologies are paraneoplastic, postinfectious and toxic-metabolic. However post-vaccinal etiology was rarely reported in OF. Here, we reported a post-vaccinal clinical syndrome characterized by OF-myoclonus and ataxia associated with oligoclonal bands (OCBs). A 60-year-old male who presented with dizziness, unsteady gait, involuntary movements, involuntary conjugate eye oscillations and extremity jerks that started 3 days after the second dose of mRNA BNT162b2 Covid-19 vaccine. Routine biochemical and serological analysis were within normal limits. No pathological finding was detected in brain MRI. Paraneoplastic and autoimmune encephalitis tests were unremarkable in cerebrospinal fluid (CSF). Oligoclonal bands were positive in CSF. This is the first description of the relationship between vaccines against SARS-CoV-2 and the clinical syndrome of OF, Myoclonus and Ataxia (OFMAS). Humoral immune mechanisms seem to play an important role in OFMAS. Presence of OCBs in CSF may also be associated with this condition. © 2022 by Turkish Association of Neuropsychiatry.Article The Relationship Between Daily Carbonhydrate and Fat Intake a Long With Migraine(2022) Eşkut, Neslihan; Uysal, Armağan; Ataç, CeylaThe pathophysiology of migraine is not fully understood. The trigeminovascular pathway activation, cortical spreading depression, vascular dysfunction, pro-inflammatory and oxidative states, and gut microbiota are investigated. In this study, we aimed to evaluate the relationship between diet and migraine disease characteristics of our patients. This study was conducted with episodic migraine without aura (n:30) and chronic migraine patients (n:30). Demographic data, body mass indexes (BMI), migraine characteristics were recorded from headache diaries. Food consumption were noted Daily from diet diaries. Total calorie intake and carbohydrate and fat amounts were calculated with an internet-based calorie calculator program.The mean age was 40.1±7.83 years in chronic migraine group ( group 1), and 39.1±6.09 years in group 2. The mean BMI of group 1 was significantly higher (respectively; 28.3±3.14, and 24.9±3.29). The mean duration of migraine was found longer in group 1. The mean headache attack duration was 29.9±21.85 hours in group 1, and 29.6±22.4 was in episodic migraine without aura group (group 2). There was no significant difference between both groups in terms of headache attack duration. Average Daily carbohydrate intake is 178.53±44.86 grams in group 1, and 171.42±50.67 grams in group 2. The mean Daily fat intake was 58.01±13.65 grams in group 1 and 56.62±7.51 grams in group 2. No significant difference was found between the groups in terms of Daily calorie, mean Daily fat and, average carbohydrate intake. In our study, we did not find difference in food intake between groups, but BMI of the chronic migraine group were higher. The role of diet on the migraine pathophysiology is still under investigation. An integrative approach to migraine patients by reviewing their diet will help to understand the pathophysiology of migraine, increase the quality of life of patients and prevent unnecessary drug usage.Article Ocular Flutter-Myoclonus-Ataxia Syndrome After mRNA BNT162b2 COVID-19 Vaccine: A Case Report(Turkısh Neuropsychıatry Assoc-Turk Noropsıkıyatrı Dernegı, 2023) Poyraz, Turan; Varol, Armagan; Uysal, ArmağanOcular flutter (OF) is a rare oculomotor syndrome. The most common etiologies are paraneoplastic, postinfectious and toxic-metabolic. However post-vaccinal etiology was rarely reported in OF. Here, we reported a post-vaccinal clinical syndrome characterized by OF-myoclonus and ataxia associated with oligoclonal bands (OCBs).A 60-year-old male who presented with dizziness, unsteady gait, involuntary tremors, involuntary conjugate eye oscillations and extremity jerks that started 3 days after the second dose of mRNA BNT162b2 Covid-19 vaccine. Routine biochemical and serological analysis were within normal limits. No pathological finding was detected in Brain MRI.Paraneoplastic and autoimmune encephalitis tests were unremarkable in cerebrospinal fluid (CSF). Oligoclonal bands were positive in CSF. This is the first description of the relationship between vaccines against SARS-CoV-2 and the clinical syndrome of OF, Myoclonus and Ataxia (OFMAS). Humoral immune mechanisms seem to play an important role in OFMAS. Presence of OCBs in CSF may also be associated with this condition.Article Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful in the Follow-Up of Cognitive Functions in Cognitively Normal Parkinson's Disease Patients?(Tubitak Scientific & Technological Research Council Turkey, 2024) Uysal, Hasan Armağan; Hunerli, Duygu; Çakmur, Raif; Dönmez Çolakoğlu, Beril; Ada, Emel; Yener, GörsevBackground/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PDCN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients. Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and part B, the Stroop test, semantic and phonemic fluency tests, and clock drawing test. Magnetic resonance imaging (MRI) was acquired according to the Alzheimer's disease neuroimaging initiative (ADNI) protocol. Results: There were no significant differences among groups regarding age, sex, handedness, and years of education. In the comparison of the PD-CN group and the HC group, there was a statistical decrease in the total animal scores, lexical fluency, TMT part A and TMT part B scores in the PD-CN group. Subcortical gray matter volumes (GMV) were significantly lower in PD-CN patients. The PD-CN group had a significantly reduced total volume of right putamen and left angular gyrus compared to that in the HC group. We observed that putamen and angular gyrus volumes were lower in PD-CN patients. On the other hand, TMT part B may be a useful pretest in detecting the conversion of mild cognitive impairment in PD. Conclusion: Significant MRI volumetric measurements and neuropsychological test batteries can be helpful in the clinical follow-up in PD-CN patients.Article Demansın Davranışsal ve Psikolojik Belirtileri Bilgi Ölçeği’nin Türkçe Versiyonunun (DDPB-T) Geçerliliği ve Güvenilirliği: Bakıcılar Arasında Psikometrik Bir Değerlendirme(Turkiye Sinir ve Ruh Sagligi dernegi, 2024) Var, Levent; Güllüoğlu, Halil; Uysal, Hasan Armağan; Poyraz, Turan; Başaran, Simay; Eşkut, NeslihanAmaçArticle Türk Erişkin Nöroloji Uzmanlarında Tükenmişlik(Galenos Publ House, 2023) Uysal, Hasan Armagan; Keskin, Ahmet Onur; Güllüoğlu, Halil; Yildiz, Fatma GokcemAmaç: Tıp doktorlarında tükenmişlik hasta bakımını veya klinisyenin fiziksel performansını kötü etkileyebilir. Çalışmamızda Türk nöroloji uzmanlarındaki tükenmişlik oranını ve tükenmişlikle ilişkili faktörleri araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya Türkiye’deki nöroloji uzmanları dahil edildi. Katılımcılardan çeşitli düşünce ve deneyimler ile ilişkili 33 sorudan oluşan bir anketi doldurmaları istendi. Katılımcılar sorulara şu şekilde cevap verdiler: Kesinlikle katılmıyorum, kısmen katılıyorum, katılıyorum, kuvvetle katılıyorum, kesinlikle katılıyorum. Sorunun anlamına göre (negatif veya pozitif), verilen cevap 1-5 arasında puanlandırıldı. Puanların toplamının maksimum (165) puana bölünmesiyle tükenmişlik oranı elde edildi. Bulgular: Ortalama yaş 38,78 (±8,42) yıl, kadın/erkek oranı 461/255 olarak bulundu. Ortalama tükenmişlik oranı %46,73 (±8,95) idi. Erkek cinsiyet, akademisyenlik, akademik derecenin yüksek olması, tıp fakültesi hastanesinde çalışmak, düşük maaş, bekar olmak, ebeveyn olmamak, nöbet tutmak, icapçı olmamak veya yoğun bakım ünitesinde çalışmak daha yüksek tükenmişlik oranı ile ilişkili bulundu. Tükenmişlik oranı, yaş, muayene edilen hasta sayısı ve çalışma saatleri ile pozitif, yardımcı sağlık personeli veya nörolog sayısı ile negatif korelasyon içindeydi. Sonuç: Bizim çalışmamız, Türk erişkin nöroloji uzmanlarından oluşan büyük bir örneklemde yüksek tükenmişlik oranını gösteren ilk çalışmadır. Erkek olmak, ileri yaş, akademisyen, profesör veya bekar olmak, ebeveyn olmamak, tıp fakültesi hastanesinde veya yoğun bakım ünitesinde çalışmak, düşük maaş, nöbet tutmak, yüksek hasta sayısı veya çalışma saati tükenmişlikle ilişkili görünmektedir.Article Citation - WoS: 2Differences in the Differential Expression of Micrornas Between Patients With Familial Multiple Sclerosis and Those With Sporadic Multiple Sclerosis(Galenos Publ House, 2023) Güllüoğlu, Halil; Uysal, Hasan Armağan; Poyraz, Turan; Altun, Zekiye; Kaya, Derya; Özcelik, Pınar; İdiman, Egemen; Poyraz, TuranObjective: Multiple sclerosis (MS) is a heterogeneous disease with clinical and immunological features. Most MS cases occur sporadically, but a considerable proportion of patients have a family history of MS. The etiology and pathophysiology of MS remain unclear. Recent epidemiological and gene expression studies have indicated that dysregulation of microRNAs (miRNAs) may play a role in MS pathogenesis. This study aimed to evaluate the differential expression of miRNAs in sporadic MS (sMS) and familial MS Materials and Methods: This cross-section, single-center study was conducted in 20 FMS and 10 sMS patients and 8 healthy controls. The patients were in the remission. In total, 2,549 miRNA genes were screened in the blood mononuclear cells from the whole blood samples of MS patients depending on miRBase 21. Differential expression of miRNAs in MS patients was identified compared with the control group, and miRNAs with a fold change >= 2 were validated using reverse transcription-polymerase chain reaction. Differentially expressed miRNAs were then compared between FMS and sMS patients. Results: Initial findings showed that miR-5100 and hsa-miR-16-2-3p were increased and miR-432-3p was decreased in FMS compared with sMS, whereas miR-548-aa, hsa-miR-142-3p, and miR-451-b were increased in both sMS and FMS, but miR-548-v was increased only in sMS. Some miRNAs showed the same expression patterns in both groups. Conclusion: Differential expression of certain miRNAs may be a useful biomarker in the diagnosis of MS. This study showed that miRNAs may discriminate between FMS and sMS cases and MS subtypes, as indicated in earlier studies.Article Citation - WoS: 1Citation - Scopus: 1An Artificial Intelligence Model for Lhermitte's Sign in Patients With Pediatric-Onset Multiple Sclerosis: a Follow-Up Study(Wroclaw Medical Univ, 2025) Uysal, Hasan A.; Poyraz, Turan; Gulluoglu, Halil; Idiman, Fethi; Idiman, EgemenBackground. Lhermitte's sign (LS) is an important clinical marker for patients with multiple sclerosis (MS). Research on pediatric-onset MS (POMS) and LS is limited. To date, there has been no research conducted on the clinical and artificial intelligence (AI)-based radiological correlation of LS. Objectives. This follow-up study aims to investigate the relationship between LS and clinical findings according to AI-based radiological characteristics of patients with POMS. Materials and methods. Basic descriptive statistics of patients with POMS according to sociodemographic, clinical and radiological findings were collected. Variables were evaluated at a 95% confidence level (95% CI), and a value of p < 0.05 was accepted as statistically significant. The LS in patients with MS was classified according to its presence in the past and at the time of the study screening: group A: absent; group B: positive in the past but absent at screening; group C: present both in the past and at the screening; group D: absent in the past but present at the screening. In addition, patients were grouped according to the duration of their MS, with the following classifications: <10 years and at least 10 years. Results. A total of 1,298 records were identified in the database search. Ninety-two patients who met the inclusion criteria were included in the study. The frequency of upper cervical lesions (C1-4 vertebral segmental levels) was higher in group B and C than in group A (p = 0.017). Among patients with an MS duration of 10-years, C1-4 lesions were least frequent in group A. Conclusions. Spinal imaging with AI-based programs can be used at least as much as brain magnetic resonance imaging (MRI) for early diagnosis, prognosis and treatment response. We have for the first time investigated LS in a large sample of patients with POMS. It is, however, recommended to conduct further multicenter studies to more specifically identify LS in patients with POMS.
