Adalı, Yasemen
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Adalre, Yasemen
Adali, Yasemen
Adali, Yasemin
Adali, Yasemen
Adali, Yasemin
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yasemen.adali@ieu.edu.tr
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09.03. Medicine
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Former Staff
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Sustainable Development Goals
5
GENDER EQUALITY
0
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
13
CLIMATE ACTION
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
14
LIFE BELOW WATER
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
1
NO POVERTY
0
Research Products
2
ZERO HUNGER
0
Research Products
4
QUALITY EDUCATION
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
1
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
3
GOOD HEALTH AND WELL-BEING
8
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
15
LIFE ON LAND
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
Documents
38
Citations
265
h-index
10
Documents
46
Citations
246
Scholarly Output
25
Articles
21
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0/0
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0
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0
WoS Citation Count
52
Scopus Citation Count
55
WoS h-index
5
Scopus h-index
6
Patents
0
Projects
1
WoS Citations per Publication
2.08
Scopus Citations per Publication
2.20
Open Access Source
17
Supervised Theses
0
| Journal | Count |
|---|---|
| Bıologıcal Trace Element Research | 2 |
| İzmir Tepecik Eğitim Hastanesi Dergisi | 2 |
| Journal of advances in vetbio science and techniques | 2 |
| Journal of Experimental and Clinical Medicine (Turkey) | 2 |
| Obesıty Surgery | 2 |
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25 results
Scholarly Output Search Results
Now showing 1 - 10 of 25
Correction Therapeutic Efects of Boric Acid in a Septic Arthritis Model Induced by Escherichia Coli in Rats (jan, 10.1007/S12011-021-03065-7, 2022)(Springernature, 2023) Yildiz, Kadri; Makav, Mustafa; Adali, Yasemen; Bulut, Menekse[Abstract Not Available]Article Citation - WoS: 6Citation - Scopus: 6Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association With Gleason Score(Hindawi Ltd, 2021) Ulusoy, M. Hakan; Cirak, Yalcin; Adali, YasemenLipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters including response to docetaxel treatment, Gleason score, progression-free survival (PFS), and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant prostate cancer (mCRPC) patients whose clinical outcomes had been tracked after docetaxel treatment. The expression status of lipocalin-2 was defined by immunohistochemistry (IHC) using the anti-lipocalin-2 antibody. Lipocalin-2 was highly expressed in 36% of the examined specimens. There was no significant correlation between high lipocalin-2 expression and docetaxel response (p:0.09). High lipocalin-2 expression was signi?cantly associated with a higher Gleason score (p=0.027). Kaplan-Meier survival analysis failed to show a significant correlation between expression levels of lipocalin-2 and both OS and PFS although patients with high lipocalin-2 levels had a numerically shorter PFS and OS time compared to patients with low levels. Consequently, it is clear that further studies are needed to evaluate the predictive and prognostic role of lipocalin-2 in prostate cancer patients.Article Citation - WoS: 9Citation - Scopus: 9The Role of Aqp3 and Aqp4 Channels in Cisplatin-Induced Cardiovascular Edema and the Protective Effect of Melatonin(Springer, 2021) Koral, Lokman; Ovali, Mehmet Akif; Tufekcioglu, Nezahat Kubra; Karakilic, Ersen; Adali, Yasemen; Uzun, MetehanBackground The present study evaluates the development of edema, the change in the AQP3, AQP4, p53 and Bax gene expressions, and the protective effects of melatonin in rat hearts administered with cisplatin. Methods and Results A total of 28 Wistar albino rats were divided into four groups. The vehicle was administered intraperitoneally (i.p.) to the rats in the control group. The melatonin group (Mel) received melatonin at a dose of 10 mg/kg for 13 days. The cisplatin group (Cis) received cisplatin on days 1, 5, 9 and 13 at a dose of 4 mg/kg. The rats in the cisplatin + melatonin (Cis+Mel) group underwent the procedures both in the Mel and Cis groups. Blood and left ventricular samples were taken and analyzed on day 14 of the study. AQP3, p53 and Bax gene expressions were found to be significantly increased following cisplatin administration compared to the control, while melatonin administration significantly decreased the expression of these genes (p < 0.05). Melatonin administration also significantly decreased the level of AQP4 gene expression compared to the cis. On histological examination, congestion, hemorrhage, extracellular and intracellular edema, and degenerative changes were significantly more common in the Cis than in the control. Melatonin administration significantly decreased intracellular edema (p = 0.010) and degenerative changes (p = 0.010), and the improvement in extracellular edema was close to statistical significance (p = 0.051) in melatonin. Conclusions These results indicate that melatonin had an ameliorative effect on myocardial edema and AQP channels, and that it may be used as a protective molecule against myocardial edema secondary to cisplatin administration.Article Could Arni Have an Effect on Lv Fibrosis and Inflammatory Parameters in an Experimental Autoimmune Myocarditis Model?(2022) Duygu, Ali; Adalı, Yasemen; Öztopuz, Özlem; Deveci, Bülent; Gazi, Emine; Arslan, MehmetObjectives: The aim of this study is to investigate the efficacy of sacubitril-valsartan treatment in the early period of Experimental Autoimmune Myocarditis (EAM) model, under the perspective of fibrosis and inflammatory cytokines. Methods: The study was performed using 18 rats in three groups of EAM (n=6), EAM treatment (n=6) and control (n=6). EAM was induced by footpad injections of porcine cardiac myosin and Complete Freund’s Adjuvant (CFA). The EAM group was not given any medical care. 20 mg/kg sacubitril-valsartan was given to EAM treatment (marked as treatment) group twice a day beginning from the 21st day to the 42nd day. No procedure was applied to the control group. Histopathological, biochemical and RT-PCR analyses were performed on the heart tissues taken after the 42nd day of sacrificing. Results: Significant congestion, fibrosis, and cellular changes were observed in the EAM and treatment groups. There was 50% less severe fibrosis,which is 3rd degree, in the Treatment group compared to EAM. Severe congestion rate was lower in the treatment group compared to EAM; with the percentage of 16,6% to 50%. Though the average values of treatment group were lower than EAM group, there was obvious difference in TNF ?, TGF ?1 and NT-proBNP levels (p>0.05) between the EAM and the treatment groups. There was no significant difference in IL-6 levels between the three groups. Conclusion: In view of findings, the treatment of ARNI in acute autoimmune myocarditis may be promising on cardiac risk markers (cytokine, BNP values) and fibrosis parameters. Studies to be conducted in high-numbered groups will reveal more statistical significance.Article Which Material Should Be Used for Mast Cell Evaluation in Gastric Cancer: Endoscopic Material or Resection Material?(2023) Adali, Yasemen; Cantay, Hasan; Anuk, Turgut; Gonullu, Dogan; Binnetoglu, Kenan; Sulu, Barlas; Beşeren, HaticeAmaç: Mide tümörlerinin prognozunda önemli olan parametrelerin de- ğerlendirilmesinde histopatolojik inceleme önemli bir yer tutmaktadır. Histopatolojik incelemede kılavuzlarda yer alan prognostik verilerin dı - şında gözlenen tümör davranışı için önemli olabilecek diğer veriler de değerlendirilmektedir. İmmun sistem elemanları arasında yer alan mast hücreleri bu veriler arasında yer almaktadır. Bu çalışmada mast hüc - relerinin değerlendirilmesi için kullanılabilme potansiyeli olan endos - kopik biyopsi materyalleri ile rezeksiyon materyallerinin karşılaştırılması amaçlanmaktadır. Materyal ve Metot : Çalışmaya aynı hastaya ait endoskopik biyopsi ve rezeksiyon materyali bulunan 19 mide tümörü olgusu dâhil edilmiştir. Tümörü temsil eden preparatlara ait parafin bloklardan elde edilen kesit - lere toludin blue histokimyası uygulanmıştır. Işık mikroskopik değerlendir- mede mast hücrelerinin en yoğun olduğu alan 100× büyütmede seçilmiş ve sonrasında 400× büyütmede tümör içinde ve çevresinde 100 hücre sayılmıştır. Bu 100 hücrenin içinde yer alan toludin blue ile pozitif boyanan mast hücreleri not edilmiştir. Mast hücresi sayısının gruplar arası anlam - lılığı analizlerinde Mann-Whitney U, gruplar arası korelasyonda Pearson testi kullanılmıştır. Bulgular: Endoskopik biyopsi materyalinde tümör içinde yer alan mast hücre sayısı (TİMH) ortalama 1,32±2,65, tümör çevresi mast hücresi sayı- sı (TÇMH) ortalama 1,0±1,76; rezeksiyon materyallerinde TİMH sayısı or- talama 4,84±4,86, TÇMH sayısı ortalama 5,63±6,99 olarak hesaplanmış- tır. Analizlerde endoskopik biyopsiler ve rezeksiyon materyalleri arasında TİMH sayısı (p=0,001) ve TÇMH sayısı (p=0,000) arasında istatistiksel an- lamlı farklılık izlenmiştir. Tüm olgular incelendiğinde TİMH sayısı ile TÇMH sayısının pozitif korelasyon gösterdiği saptanmıştır. Ancak endoskopik biyopsiler ile rezeksiyon materyalleri kıyaslandığında TİMH veya TÇMH açısından herhangi bir korelsayon olmadığı dikkati çekmiştir. Sonuç: İmmun yanıtın önemli bir unsuru olan mast hücreleri çeşitli tümörlerde olduğu gibi mide kanserlerinde de farklı yönleri ile değer - lendirilmektedir. Sunulan çalışma sonuçları yanısıra tümör ve tümör mikroçevre incelemesinin önemi göz önünde bulundurulduğunda ge- lecekte mide tümörlerinde önemli bir belirteç olma potansiyeli bulunan mast hücrelerinin rezeksiyon materyalinde değerlendirilmesi gerektiği, endoskopik materyal değerlendirmelerinin gerçek tabloyu yansıtmadığı düşünülmektedir.Article Citation - WoS: 7Citation - Scopus: 7The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: an Experimental Study(Sage Publications Inc, 2021) Buyuk, Basak; Aydeger, Cemre; Adali, Yasemen; Eroglu, Huseyin AvniBackground: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated. Methods: Forty adult female rats were used in the study. A full-thickness excisional wound model was created in all groups divided as Control, Fito, Boron and Plu groups. After the applications performed twice a day and lasting 7 days, skin tissues obtained and evaluated histopathological (inflammatory cell infiltration, oedema, and fibroblast proliferation density) and immunohistochemical (TNF-alpha, EphrinA1, EphrinB1, EphrinB2 and EphB4). Results: Inflammatory cell infiltration score was found to be higher in the Fito group compared to Boron group (p = .018). Fibroblast proliferation density was higher in Plu group than Boron group (p = .012). While TNF-alpha was lower in boron group than Plu (p = .027) and Fito (p = .016) groups, EphrinA1 was higher in Boron group than Plu group (p = .005). EphrinB1 expression was higher in Boron group compared to Plu (p = .015) and Fito (p = .015) groups, and the same difference was also observed in EphrinB2 (p values .000). Similarly, EphB4 immunoreactivity was higher in the Boron group compared to Plu (p = .000) and Fito (p = .002). Conclusion: One of the mechanisms of action of boron in wound healing is to increase EphrinB1, EphrinB2 and EphB4. Low TNF-alpha and histopathological findings indicate that boron limits extensive wound healing.Article Complications and Therapeutic Approaches in a Sciatic Nerve Injury Rat Model(2025) Adali, Yasemen; Barış, Elif; Daştan, Ali Engin; Öztürk, VolgaSciatic nerve injury (SNI) is a common model for studying peripheral nerve damage and regeneration. This study investigates the complications associated with acute nerve injury (ANI) by laceration of sciatic nerve in rats including infection, edema, and cannibalism, and evaluates the effectiveness of therapeutic interventions to modulate the observed complications. For this purpose eighteen female wistar albino rats were divided into three groups: control, sham-operated, and ANI. The ANI model induced with dissection and repair of the right sciatic nerve. Post-surgical care included the administration of diclofenac sodium for pain management. Observations were made for signs of infection, edema, hematoma, and survival rates within 10 days. The ANI group showed significant complications, including a 41.6% incidence of symptoms of pain (paraesthesia, allodynia, hyperalgesia, decreased activity, piloerection, excessive licking, un-groomed appearance) within 3 days, which increased to 60% by day 5. Edema was observed in 8.3% of the ANI rats, and 33.3% developed hematomas. Cannibalism rates also increased, particularly within 10 days post-injury. Survival rates in the ANI group decreased to 16.6% by day 10, indicating severe post-operative complications. The current study highlights the critical complications associated with ANI in rats, particularly the high rates of pain related symptoms (i.e. paresthesia and cannibalism). These findings suggest the need for improved post-operative care and highlight the importance of therapeutic interventions like opioid analgesics to mitigate these complications and enhance recovery outcomes in peripheral nerve injury models.Article Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout With Comparison of Dexamethasone and Indomethacin(Springer, 2024) Aydeğer, Cemre; Adalı, Yasemen; Makav, Mustafa; Eroğlu, Hüseyin AvniGout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft tissues. The treatment for gout arthritis is centered on reducing uric acid agents with long-term and anti-inflammatory agents during attack times. In recent studies, it is noteworthy that Indomethacin and Dexamethasone have positive effects in the treatment of gout. Dimethyl sulfoxide (DMSO) is a lipophilic solvent and has an anti-inflammatory effect at appropriate doses. Based on this information, for this study, the effects of these three agents were investigated in rats using a gut model to compare their efficacy. In the study, a total of 48 female 3-4-month rats were divided equally into 8 groups: Control, Indomethacin, DMSO, Dexamethasone, Gout, Gout+Indomethacin, Gout+DMSO, Gout +Dexamethasone. During the eight-week study, a gout arthritis model was used that included 10 mg MSU given intra-articularly in the right foot. Indomethacin 12.5 mg/kg intragastric, DMSO 0.1 ml intraperitoneally and dexamethasone 0.2 mg/kg were administered subcutaneously to the related groups once a day for seven days. At the end of the study, collected articular tissues were stained with haematoxylin and eosin after the fixation and decalcification processes were done. The findings obtained showed that inflammation was reduced in treatment groups compared to the Control groups (all p values 0.002). Also, synovial proliferation was remarkably decreased in the Gout+Dexamethasone group compared to the Gout group (p = 0.019). As a result of these findings, although the three agents all reduced inflammation in gout arthritis, DMSO was shown to be more advantageous due to its having fewer side-effects.Article Citation - WoS: 9Citation - Scopus: 8Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia Coli in Rats(Springernature, 2022) Yildiz, Kadri; Makav, Mustafa; Adali, Yasemin; Bulut, MenekseThe study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor group. Escherichia coli was administered at a single dose of 25 mu L, 1 x 10(10) cfu/rat from the right foot pad of the rats, via intra-articular route, to the mice in the arthritis, arthritis-bor, and arthritis-antb groups. Then, BA at a dose of 50 mg/kg and cefazolin at a dose of 25 mg/kg were administered to the rats in the arthritis-bor and arthritis-antb groups, respectively, for 7 days via the IP route. At the end of the study, all animals were euthanized following the ethical rules. Blood and tissue samples were taken from the rats for biochemical and histopathological analyses. The levels of GSH, MDA, Endoglin, Endocan, and TNF-beta markers were measured in the blood samples taken. A significant decrease was observed in MDA and Endoglin levels in the boric acid-administered group compared with the arthritis group, while a significant increase was observed at the GSH level. Histopathologically, it was determined that the reactive surrounding tissue response in the bor group was significantly reduced. As a result, a significant decrease in inflammation was found biochemically and histopathologically in the groups treated with BA.Letter Could Ghrelin Be a Predictive Marker for Postoperative Weight Loss?(Springer, 2023) Adali, Yasemen[Abstract Not Available]
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