Adalı, Yasemen
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Adalre, Yasemen
Adali, Yasemen
Adali, Yasemin
Adali, Yasemen
Adali, Yasemin
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yasemen.adali@ieu.edu.tr
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09.03. Medicine
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38
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265
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10
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46
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246
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25
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21
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150/151
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52
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55
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2.08
Scopus Citations per Publication
2.20
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17
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| Journal | Count |
|---|---|
| Bıologıcal Trace Element Research | 2 |
| İzmir Tepecik Eğitim Hastanesi Dergisi | 2 |
| Journal of advances in vetbio science and techniques | 2 |
| Journal of Experimental and Clinical Medicine (Turkey) | 2 |
| Obesıty Surgery | 2 |
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Now showing 1 - 10 of 25
Article Parathyroid Lesions: Our Single-Center Experience Forthe Last 5 Years(2021) Ekmekçi, Sümeyye; Küçük, Ülkü; Pala, Emel Ebru; Üstün, Mehmet; Atıcı, Semra Demirli; Adalı, YasemenObjective: Parathyroid neoplasms are tumors seen in about 0.1% of the population. Although parathyroid adenomas are the most common, rarely carcinomas are also seen. Our aim in this study is to evaluate the clinical, laboratory and histopathological characteristics of patients who underwent parathyroidectomy in our hospital in the last 5 years.Method: A total of 156 patients who underwent parathyroidectomy in our hospital and examined in the pathology department were included in the study. Cases were grouped according to the types of operations performed as those who underwent only parathyroid excision or partial/total thyroid excision with parathyroid excision. Age, gender, pre- and post-operative parathyroid hormone values, size, weight, pathological diagnosis of the parathyroid gland, presence of complications, comorbidities and their clinical follow-ups were evaluated.Results: The 84% of 156 cases were female, and 16% were male. The mean age of the patients was 53.82±13.49 years. The mean pre-, and post-operative parathyroid hormone levels of the cases were 415.18±491.15 mg/dl, and 64.02±110.72 mg/dl, respectively. The mean volume of parathyroid tissues was calculated as 5.13±8.85 and the mean weight as 2.78±2.88 g. Pathological diagnoses were adenoma in 83.3%, hyperplasia in 10.9%, atypical adenoma in 2.6%, carcinoma in 1.9%, normal parathyroid gland in 0.6% and lymph node in 0.6%, of the cases. It was observed that as the postoperative PTH level increased, the weight of the parathyroid gland increased and the weight of the lesion was higher in males. The addition of thyroidectomy to the treatment, conventional parathyroidectomy instead of the minimally invasive method, and the high size and volume of the parathyroid gland were found to be associated with complications in the postoperative period.Conclusion: In terms of thyroid pathologies that may accompany, it will be more appropriate to evaluate preoperative cases in detail and to continue the treatment with minimally invasive methods for the comfort of the patient in postoperative processes. It is highly important to always take a multidisciplinary management in the approach to parathyroid masses and to evaluate the clinical, laboratory, intraoperative and pathological findings of the cases in combination.Article Citation - Scopus: 2The Effects of Thiopental on Cold Ischemic Injury in Renal Transplantation(NLM (Medline), 2023-02-28) Büyük B.; Adali Y.; Karakoç E.; Eroğlu H.A.; Aydeğer C.; Eroğlu, Hüseyin Avni; Aydeğer, Cemre; Büyük, Başak; Karakoç, Ebru; Adali, YasemenINTRODUCTION: One of the most important factors influencing post-transplant success in kidney transplantation is preserving the viability of the organ from removal to transfer into the recipient. AIM: This study aimed to reduce the energy requirement with thiopental doses administered before organ transplantation, and to increase the organ viability by minimizing the tissue damage during the cold ischemia process. MATERIALS AND METHODS: Twenty female Wistar albino rats were divided into two groups: control group (group C), and thiopental group (group T). In group C, a midline incision was performed, and the renal artery was isolated under ketamine and xylazine anesthesia. A standard organ storage solution (cooled to +4°C) was used for kidney perfusion. Nephrectomy was applied, and the removed kidneys were placed into +4°C standard organ storage solution and stored at +4°C for 12 hours. Animals in group T were subjected to the procedures explained above under 85 mg/kg thiopental sodium anesthesia. After 12-hour storage, samples from the kidney tissues were fixed in 10% neutral buffered formalin. Histopathological evaluation and apoptosis detection via TUNEL method were performed. RESULTS: Tubular necrosis was more extensive in group C compared with that in group T and this difference was statistically significant. Similarly, vacuolization was widely observed in group C, and this increase was also statistically significant. For the 'dilatation of Bowman's space' parameter, a significant decrease was observed in group T compared with group C. When the apoptotic index values of both groups were examined, it was seen that they were lower in group T than those in group C. This result was statistically significant. CONCLUSIONS: These data suggest that thiopental provides protection to the kidney tissue during the cold storage process. Thiopental has been shown to decrease the number of apoptotic cells in the kidney tissue when administered to the donor before organ transplantation, increasing the organ viability. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Correction Therapeutic Efects of Boric Acid in a Septic Arthritis Model Induced by Escherichia Coli in Rats (jan, 10.1007/S12011-021-03065-7, 2022)(Springernature, 2022-02-07) Yildiz, Kadri; Makav, Mustafa; Adali, Yasemen; Bulut, Menekse[Abstract Not Available]Article Citation - WoS: 6Citation - Scopus: 6Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association With Gleason Score(Hindawi Ltd, 2021-01-20) Ulusoy, M. Hakan; Cirak, Yalcin; Adali, YasemenLipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters including response to docetaxel treatment, Gleason score, progression-free survival (PFS), and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant prostate cancer (mCRPC) patients whose clinical outcomes had been tracked after docetaxel treatment. The expression status of lipocalin-2 was defined by immunohistochemistry (IHC) using the anti-lipocalin-2 antibody. Lipocalin-2 was highly expressed in 36% of the examined specimens. There was no significant correlation between high lipocalin-2 expression and docetaxel response (p:0.09). High lipocalin-2 expression was signi?cantly associated with a higher Gleason score (p=0.027). Kaplan-Meier survival analysis failed to show a significant correlation between expression levels of lipocalin-2 and both OS and PFS although patients with high lipocalin-2 levels had a numerically shorter PFS and OS time compared to patients with low levels. Consequently, it is clear that further studies are needed to evaluate the predictive and prognostic role of lipocalin-2 in prostate cancer patients.Article Investigation of the Effects of Dimethyl Sulfoxide in Experimental Gout With Comparison of Dexamethasone and Indomethacin(Springer, 2024-06) Aydeğer, Cemre; Adalı, Yasemen; Makav, Mustafa; Eroğlu, Hüseyin AvniGout arthritis is an inflammatory arthritis characterized by increased serum uric acid and accumulation of monosodium urate (MSU) crystals in soft tissues. The treatment for gout arthritis is centered on reducing uric acid agents with long-term and anti-inflammatory agents during attack times. In recent studies, it is noteworthy that Indomethacin and Dexamethasone have positive effects in the treatment of gout. Dimethyl sulfoxide (DMSO) is a lipophilic solvent and has an anti-inflammatory effect at appropriate doses. Based on this information, for this study, the effects of these three agents were investigated in rats using a gut model to compare their efficacy. In the study, a total of 48 female 3-4-month rats were divided equally into 8 groups: Control, Indomethacin, DMSO, Dexamethasone, Gout, Gout+Indomethacin, Gout+DMSO, Gout +Dexamethasone. During the eight-week study, a gout arthritis model was used that included 10 mg MSU given intra-articularly in the right foot. Indomethacin 12.5 mg/kg intragastric, DMSO 0.1 ml intraperitoneally and dexamethasone 0.2 mg/kg were administered subcutaneously to the related groups once a day for seven days. At the end of the study, collected articular tissues were stained with haematoxylin and eosin after the fixation and decalcification processes were done. The findings obtained showed that inflammation was reduced in treatment groups compared to the Control groups (all p values 0.002). Also, synovial proliferation was remarkably decreased in the Gout+Dexamethasone group compared to the Gout group (p = 0.019). As a result of these findings, although the three agents all reduced inflammation in gout arthritis, DMSO was shown to be more advantageous due to its having fewer side-effects.Article Citation - WoS: 7Citation - Scopus: 7The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: an Experimental Study(Sage Publications Inc, 2021-11-13) Buyuk, Basak; Aydeger, Cemre; Adali, Yasemen; Eroglu, Huseyin AvniBackground: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated. Methods: Forty adult female rats were used in the study. A full-thickness excisional wound model was created in all groups divided as Control, Fito, Boron and Plu groups. After the applications performed twice a day and lasting 7 days, skin tissues obtained and evaluated histopathological (inflammatory cell infiltration, oedema, and fibroblast proliferation density) and immunohistochemical (TNF-alpha, EphrinA1, EphrinB1, EphrinB2 and EphB4). Results: Inflammatory cell infiltration score was found to be higher in the Fito group compared to Boron group (p = .018). Fibroblast proliferation density was higher in Plu group than Boron group (p = .012). While TNF-alpha was lower in boron group than Plu (p = .027) and Fito (p = .016) groups, EphrinA1 was higher in Boron group than Plu group (p = .005). EphrinB1 expression was higher in Boron group compared to Plu (p = .015) and Fito (p = .015) groups, and the same difference was also observed in EphrinB2 (p values .000). Similarly, EphB4 immunoreactivity was higher in the Boron group compared to Plu (p = .000) and Fito (p = .002). Conclusion: One of the mechanisms of action of boron in wound healing is to increase EphrinB1, EphrinB2 and EphB4. Low TNF-alpha and histopathological findings indicate that boron limits extensive wound healing.Letter Could Ghrelin Be a Predictive Marker for Postoperative Weight Loss?(Springer, 2023-02-06) Adali, Yasemen[Abstract Not Available]Article Complications and Therapeutic Approaches in a Sciatic Nerve Injury Rat Model(2025-04-30) Adali, Yasemen; Barış, Elif; Daştan, Ali Engin; Öztürk, VolgaSciatic nerve injury (SNI) is a common model for studying peripheral nerve damage and regeneration. This study investigates the complications associated with acute nerve injury (ANI) by laceration of sciatic nerve in rats including infection, edema, and cannibalism, and evaluates the effectiveness of therapeutic interventions to modulate the observed complications. For this purpose eighteen female wistar albino rats were divided into three groups: control, sham-operated, and ANI. The ANI model induced with dissection and repair of the right sciatic nerve. Post-surgical care included the administration of diclofenac sodium for pain management. Observations were made for signs of infection, edema, hematoma, and survival rates within 10 days. The ANI group showed significant complications, including a 41.6% incidence of symptoms of pain (paraesthesia, allodynia, hyperalgesia, decreased activity, piloerection, excessive licking, un-groomed appearance) within 3 days, which increased to 60% by day 5. Edema was observed in 8.3% of the ANI rats, and 33.3% developed hematomas. Cannibalism rates also increased, particularly within 10 days post-injury. Survival rates in the ANI group decreased to 16.6% by day 10, indicating severe post-operative complications. The current study highlights the critical complications associated with ANI in rats, particularly the high rates of pain related symptoms (i.e. paresthesia and cannibalism). These findings suggest the need for improved post-operative care and highlight the importance of therapeutic interventions like opioid analgesics to mitigate these complications and enhance recovery outcomes in peripheral nerve injury models.Article Citation - WoS: 9Citation - Scopus: 8Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia Coli in Rats(Springernature, 2022-01-16) Yildiz, Kadri; Makav, Mustafa; Adali, Yasemin; Bulut, MenekseThe study aimed to evaluate the therapeutic effect of boric acid (BA) in experimentally induced septic arthritis. A total of 30 rats, 6 rats in each group (5 groups), were used in the study. No treatment was applied to the rats in the control group. Only BA was administered intraperitoneally (IP) to the rats in the bor group. Escherichia coli was administered at a single dose of 25 mu L, 1 x 10(10) cfu/rat from the right foot pad of the rats, via intra-articular route, to the mice in the arthritis, arthritis-bor, and arthritis-antb groups. Then, BA at a dose of 50 mg/kg and cefazolin at a dose of 25 mg/kg were administered to the rats in the arthritis-bor and arthritis-antb groups, respectively, for 7 days via the IP route. At the end of the study, all animals were euthanized following the ethical rules. Blood and tissue samples were taken from the rats for biochemical and histopathological analyses. The levels of GSH, MDA, Endoglin, Endocan, and TNF-beta markers were measured in the blood samples taken. A significant decrease was observed in MDA and Endoglin levels in the boric acid-administered group compared with the arthritis group, while a significant increase was observed at the GSH level. Histopathologically, it was determined that the reactive surrounding tissue response in the bor group was significantly reduced. As a result, a significant decrease in inflammation was found biochemically and histopathologically in the groups treated with BA.Article Could Arni Have an Effect on Lv Fibrosis and Inflammatory Parameters in an Experimental Autoimmune Myocarditis Model?(2022) Duygu, Ali; Adalı, Yasemen; Öztopuz, Özlem; Deveci, Bülent; Gazi, Emine; Arslan, MehmetObjectives: The aim of this study is to investigate the efficacy of sacubitril-valsartan treatment in the early period of Experimental Autoimmune Myocarditis (EAM) model, under the perspective of fibrosis and inflammatory cytokines. Methods: The study was performed using 18 rats in three groups of EAM (n=6), EAM treatment (n=6) and control (n=6). EAM was induced by footpad injections of porcine cardiac myosin and Complete Freund’s Adjuvant (CFA). The EAM group was not given any medical care. 20 mg/kg sacubitril-valsartan was given to EAM treatment (marked as treatment) group twice a day beginning from the 21st day to the 42nd day. No procedure was applied to the control group. Histopathological, biochemical and RT-PCR analyses were performed on the heart tissues taken after the 42nd day of sacrificing. Results: Significant congestion, fibrosis, and cellular changes were observed in the EAM and treatment groups. There was 50% less severe fibrosis,which is 3rd degree, in the Treatment group compared to EAM. Severe congestion rate was lower in the treatment group compared to EAM; with the percentage of 16,6% to 50%. Though the average values of treatment group were lower than EAM group, there was obvious difference in TNF ?, TGF ?1 and NT-proBNP levels (p>0.05) between the EAM and the treatment groups. There was no significant difference in IL-6 levels between the three groups. Conclusion: In view of findings, the treatment of ARNI in acute autoimmune myocarditis may be promising on cardiac risk markers (cytokine, BNP values) and fibrosis parameters. Studies to be conducted in high-numbered groups will reveal more statistical significance.
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