Yener, Görsev
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Yener, G.
Yener, Gorsev
Yener, Gorsev G
Yener, Görsev G.
Yener, Gorsev Gulmen
Yener, Görsev Gülmen
Yener, GÖrsev Gülmen
Yener, Gülmen Görsev
Yenner, Gersev
Yener, G
YENER, G
Yener, G. G.
Yener, Gorsev
Yener, Gorsev G
Yener, Görsev G.
Yener, Gorsev Gulmen
Yener, Görsev Gülmen
Yener, GÖrsev Gülmen
Yener, Gülmen Görsev
Yenner, Gersev
Yener, G
YENER, G
Yener, G. G.
Job Title
Email Address
gorsev.yener@ieu.edu.tr
Main Affiliation
09.03. Medicine
Status
Former Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
Documents
192
Citations
5139
h-index
41
Documents
231
Citations
4316
Scholarly Output
58
Articles
51
Views / Downloads
2/9
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
457
Scopus Citation Count
375
WoS h-index
12
Scopus h-index
11
Patents
0
Projects
8
WoS Citations per Publication
7.88
Scopus Citations per Publication
6.47
Open Access Source
26
Supervised Theses
0
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58 results
Scholarly Output Search Results
Now showing 1 - 10 of 58
Review Article Citation - WoS: 15Citation - Scopus: 16Telehealth Applications Used for Self-Efficacy Levels of Family Caregivers for Individuals With Dementia: a Systematic Review and Meta-Analysis(Mosby-Elsevier, 2023) Soylemez, Burcu Akpinar; Ozgul, Ecem; Kucukguclu, Ozlem; Yener, GörsevBackground: The effectiveness of telehealth applications for family caregivers of individuals with dementia remains unclear. The aim of this study is to investigate how telehealth-based interventions applied for family caregivers of individuals with dementia affect their self-efficacy levels, caregiving burden, stress, depression, and quality of life.Materials and Methods: This was a systematic review. Screening took place between April 30 and May 5, 2022, for the scope of the past 10 years (January 2012/May 2022). The related studies were screened over ten (10) databases and search engines both in English and Turkish, including CINAHL, Cochrane Library, MEDLINE, PsycINFO, PubMed and Web of Science, ULAKBIM, Turkish Medline, Tu euro rkiye Klinikleri, and YOK National The - sis Center. Keywords included in various medical topic titles identified upon consultation with literature review experts from a library. Methodological quality of the studies was evaluated using Critical Appraisal Checklists developed by the Joanna Briggs Institute for experimental and quasi-experimental studies. The data were synthesized by meta-analysis. Results: Two hundred and twelve (212) records were accessed in the databases. Of that, 12 studies (covering 1,013 caregivers) were selected for the meta-analysis. Statistically, the self-efficacy mean score was signifi- cantly higher in the intervention group than the control group after the intervention (SMD: 1.08, Z=3.12, p=0.002). The effectiveness of telehealth-based applications for caregivers' caregiving burden, stress, depres- sion and quality of life -- except for self-efficacy - was evaluated. The results of the intervention and control groups were similar after the intervention (SMD:-0.17, Z=0.82, p=0.41; MD:-0.60, Z=0.49, p=0.63, SMD:-0.04, Z=0.13, p=0.98; SMD: 0.15, Z=0.47, p=0.64, respectively).Conclusions: This systematic review and meta-analysis showed that telehealth applications were effective in elevating the self-efficacy levels of caregivers of individuals with dementia. However, no statistically signifi- cant difference was observed in terms of caregiving burden, stress, depression, or quality of life for care- givers.(c) 2022 Elsevier Inc. All rights reserved.Article Citation - WoS: 1Citation - Scopus: 2Characterizing the Heterogeneity of Neurodegenerative Diseases Through Eeg Normative Modeling(Nature Portfolio, 2025) Tabbal, Judie; Ebadi, Aida; Mheich, Ahmad; Kabbara, Aya; Guntekin, Bahar; Yener, Gorsev; Hassan, MahmoudNeurodegenerative diseases like Parkinson's (PD) and Alzheimer's (AD) exhibit considerable heterogeneity of functional brain features within patients, complicating diagnosis and treatment. Here, we use electroencephalography (EEG) and normative modeling to investigate neurophysiological mechanisms underpinning this heterogeneity. Resting-state EEG data from 14 clinical units included healthy adults (n = 499) and patients with PD (n = 237) and AD (n = 197), aged over 40. Spectral and source connectivity analyses provided features for normative modeling, revealing significant, frequency-dependent EEG deviations with high heterogeneity in PD and AD. Around 30% of patients exhibited spectral deviations, while similar to 80% showed functional source connectivity deviations. Notably, the spatial overlap of deviant features did not exceed 60% for spectral and 25% for connectivity analysis. Furthermore, patient-specific deviations correlated with clinical measures, with greater deviations linked to worse UPDRS for PD (rho = 0.24, p = 0.025) and MMSE for AD (rho = -0.26, p = 0.01). These results suggest that EEG deviations could enrich individualized clinical assessment in Precision Neurology.Article Citation - WoS: 5Citation - Scopus: 6Patients With Alzheimer's Disease Dementia Show Partially Preserved Parietal 'hubs Modeled From Resting-State Alpha Electroencephalographic Rhythms(Frontiers Media Sa, 2023) Lopez, Susanna; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Padovani, Alessandro; Nobili, Flavio; Arnaldi, Dario; Yener, GörsevIntroductionGraph theory models a network by its nodes (the fundamental unit by which graphs are formed) and connections. 'Degree' hubs reflect node centrality (the connection rate), while 'connector' hubs are those linked to several clusters of nodes (mainly long-range connections). MethodsHere, we compared hubs modeled from measures of interdependencies of between-electrode resting-state eyes-closed electroencephalography (rsEEG) rhythms in normal elderly (Nold) and Alzheimer's disease dementia (ADD) participants. At least 5 min of rsEEG was recorded and analyzed. As ADD is considered a 'network disease' and is typically associated with abnormal rsEEG delta (<4 Hz) and alpha rhythms (8-12 Hz) over associative posterior areas, we tested the hypothesis of abnormal posterior hubs from measures of interdependencies of rsEEG rhythms from delta to gamma bands (2-40 Hz) using eLORETA bivariate and multivariate-directional techniques in ADD participants versus Nold participants. Three different definitions of 'connector' hub were used. ResultsConvergent results showed that in both the Nold and ADD groups there were significant parietal 'degree' and 'connector' hubs derived from alpha rhythms. These hubs had a prominent outward 'directionality' in the two groups, but that 'directionality' was lower in ADD participants than in Nold participants. DiscussionIn conclusion, independent methodologies and hub definitions suggest that ADD patients may be characterized by low outward 'directionality' of partially preserved parietal 'degree' and 'connector' hubs derived from rsEEG alpha rhythms.Review Article Citation - WoS: 10Citation - Scopus: 11Alzheimer's Disease Research Progress in the Mediterranean Region: the Alzheimer's Association International Conference Satellite Symposium(Wiley, 2022) Sexton, Claire; Solis, Michele; Aharon-Peretz, Judith; Alexopoulos, Panagiotis; Yener, Görsev; Bayen, Eleonore; Birkenhager, BettyAs research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's Association International Conference Satellite Symposium in Athens, Greece in 2021. Due to the COVID-19 pandemic, the meeting was held virtually, which enabled attendees from around the world to hear about research efforts in Greece and the surrounding Mediterranean countries. Research updates spanned understanding the biology of, treatments for, and care of people with Alzheimer's disease (AD_ and other dementias. Researchers in the Mediterranean region have outlined the local epidemiology of AD and dementia, and have identified regional populations that may expedite genetic studies. Development of biomarkers is expected to aid early and accurate diagnosis. Numerous efforts have been made to develop culturally specific interventions to both reduce risk of dementia, and to improve quality of life for people living with dementia.Article Citation - WoS: 4Citation - Scopus: 5Detecting Language Network Alterations in Mild Cognitive Impairment Using Task-Based Fmri and Resting-State Fmri: a Comparative Study(John Wiley and Sons Ltd, 2024) Kemik, K.; Ada, E.; Çavuşoğlu, B.; Aykaç, C.; Savaş, D.D.E.; Yener, G.Objective: The objective of this study was to investigate the functional changes associated with mild cognitive impairment (MCI) using independent component analysis (ICA) with the word generation task functional magnetic resonance imaging (fMRI) and resting-state fMRI. Methods: In this study 17 patients with MCI and age and education-matched 17 healthy individuals as control group are investigated. All participants underwent resting-state fMRI and task-based fMRI while performing the word generation task. ICA was used to identify the appropriate independent components (ICs) and their associated networks. The Dice Coefficient method was used to determine the relevance of the ICs to the networks of interest. Results: IC-14 was found relevant to language network in both resting-state and task-based fMRI, IC-4 to visual, and IC-28 to dorsal attention network (DAN) in word generation task-based fMRI by Sorento-Dice Coefficient. ICA showed increased activation in language network, which had a larger voxel size in resting-state functional MRI than word generation task-based fMRI in the bilateral lingual gyrus. Right temporo-occipital fusiform cortex, right hippocampus, and right thalamus were also activated in the task-based fMRI. Decreased activation was found in DAN and visual network MCI patients in word generation task-based fMRI. Conclusion: Task-based fMRI and ICA are more sophisticated and reliable tools in evaluation cognitive impairments in language processing. Our findings support the neural mechanisms of the cognitive impairments in MCI. © 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC.Article Citation - WoS: 2Citation - Scopus: 2Cognitive Evidence on Eeg-P300 in Healthy Individuals With High Depression Scores(Wolters Kluwer Medknow Publications, 2022) Oz, Didem; Ozbek, Yagmur; Kiyi, Ilayda; Ozturk, Bilge Targitay; Oztura, Ibrahim; Yener, GörsevBackground:Depression is common among elderly and middle-aged individuals and is a reason for decreased quality of life. Depression may lead to impairments in cognitive abilities. The P300 potential is one of the most used event-related potentials (ERPs) to evaluate cognition. This study investigated the P300 amplitude differences between individuals with depressive symptoms and nondepressed healthy elderly individuals. Materials and Methods:The current study included twenty individuals with high depression scores (high DS, age: 64.80 +/- 7.22, 6 M/14 F) and twenty demographically matched participants with low depression scores (low DS, age: 64.20 +/- 6.21, 7 M/13 F). The Geriatric Depression Scale (GDS) was used to evaluate whether participants have depressive symptoms. All of the participants were underwent a comprehensive neuropsychological battery. The ERPs were recorded with a visual classical oddball paradigm. The P300 amplitudes were measured in the 250-550 ms time window. Results:High DS group had lower P300 amplitudes than low DS individuals regardless of electrode location. Correlation analyses showed that there was a significant correlation between GDS scores and the P300 amplitudes recorded from the F-z electrode. Conclusion:The current study showed the reduced P300 amplitudes on individuals with high GDS scores. The P300 potential may be a useful tool to determine possible changes or impairments due to subthreshold depressive symptoms.Article Citation - WoS: 10Citation - Scopus: 11The Reliability of P300 and the Influence of Age, Gender and Education Variables in a 50 Years and Older Normative Sample(Elsevier, 2022) Yerlikaya, Deniz; Hunerli-Günduz, Duygu; Fide, Ezgi; Özbek, Yağmur; Kıyı, İlayda; Öztura, İbrahim; Yener, GörsevObjectives: The present study aims to investigate the effects of age, gender, and level of education on P300 in a healthy population, aged 50 years and over; and determine the reliability metrics for different conditions and measurement methods.Method: Auditory and visual oddball recordings of 171 healthy adults were investigated. A fully automated preprocessing was applied to elicit ERP P300. Maximum peak amplitude, latency and mean amplitudes were measured. Data were stratified by age, gender, and education to determine group-level differences by using repeat measures of ANOVA. The internal consistency of P300 was calculated by a split-half method using odd-even segments. Test-retest reliability was assessed by calculating the intraclass correlation coefficient (ICC).Results: Maximum peak P300 amplitudes were higher in the 50-64 years age group compared to the >65 years age group; and females showed increased P300 amplitudes compared to males. P300 measures showed fair to good internal consistency and poor to good test-retest reliability.Conclusion: Age and gender should be taken into account when designing ERP studies with elderly individuals. P300 showed good internal consistency in general, between gender groups and age groups. Long-term test-retest reliability was lower but acceptable. These findings can be interpreted as the strength of P300 by being an objective and reliable method independent of cultural differences. Here we underline several factors that may affect P300 measures and discuss other possible factors that should be standardized for P300 to be used in clinical settings.Review Article Citation - WoS: 2Citation - Scopus: 2Senior Moments Are Never-Ending Times When You Are Old (are They?): First Step of Turquoise Project(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2022) Oz, Didem; Yildirim, Zerrin; Kiyi, Ilayda; Ozbek, Yagmur; Kulac, Ibrahim; Erkol, Gokhan; Tihan, Tarik; Yener, GörsevIntroduction: The number of dementia patients is increasing in Turkey,, as well as all over the world. However, we do not know how much the society knows about dementia. The aim of this study is to evaluate people's concept of dementia, their awareness of dementia research and treatment, whether dementia and forgetfulness are considered normal in old age, and whether having dementia is associated with a lack of mental abilities. Methods: A Dementia Awareness Questionnaire was created in the form of a self-report questionnaire, consisting of 20 questions and using a five-point Likert-type answering method in order to question participants' information about dementia. In addition, we asked for demographic information such as age, gender, occupation, education level of the participants, as well as whether they have had relatives diagnosed with a neurodegenerative disease. The surveys were administered online. Results: A total of 1551 participants from 53 cities were included in the study. Approximately half of the participants did not know the definition of dementia, 20.9% thought that dementia and Alzheimer's disease were the same; 50.4% considered forgetfulness, and 55.2% considered dementia as a natural consequence of aging. While 34.5% of the participants thought that dementia patients could be dangerous, 10.3% thought they could not continue living as a part of society. While 38.5% of healthcare professionals do not know the definition of dementia, 18.5% of them say that dementia and Alzheimer's disease are the same, 58.5% think that dementia patients are not fit to make their own decisions, 40.6% believe that dementia patients have criminal liability. 15.8% of healthcare professionals thought that dementia is only seen in elderly people; 21.4% thought that dementia, and 49.2% thought that forgetfulness was a result of normal aging. Conclusion: Our study confirms that dementia is still an unknown concept in society and among healthcare professionals. It is widely believed that forgetfulness and dementia are part of normal aging, and there is no cure for dementia. This study, which we have done in order to understand the level of dementia awareness in Turkish society, reveals the necessity for research on dementia and studies on how to increase dementia awareness.Article Citation - WoS: 11Citation - Scopus: 10Cross-Cultural Comparison of Mmse and Rudas in German and Turkish Patients With Alzheimer's Disease(Amer Psychological Assoc, 2022) Celik, Simge; Onur, Oezguer; Yener, Görsev; Kessler, Josef; Oezbek, Yagmur; Meyer, Patric; Froelich, LutzObjective: Given the increasing cultural, linguistic diversity in Europe, there is a growing need for cognitive screening tools that minimize the influence of linguistic, cultural, and demographic differences as they are the first means to determine the need for further clinical evaluation of individuals with suspected cognitive impairment. This cross-sectional study compared performance on the Mini-Mental State Examination (MMSE) and the Rowland Universal Dementia Assessment Scale (RUDAS) in Alzheimer's Disease (AD) patients in relation to cultural, demographic, and immigration-related factors (acculturation, bilingualism). Method: The study comprised Turkish immigrant (n = 21) and monolingual, nonimmigrant German (n = 20) and Turkish (n = 24) patients with AD. All participants were administered cognitive screening tools, measures of depression, and dementia severity. Results: The mean MMSE total score was significantly higher in German patients with AD compared to both patient groups, but did not differ between native-born Turkish and Turkish immigrant groups. After adjustment for years of education, differences in MMSE performance were no longer significant between groups. Furthermore, bilingualism was associated with better performance on the MMSE in Turkish-immigrant patients. The mean RUDAS total scores were similar between groups with and without adjustment for educational level. Performance on the RUDAS was not associated with demographic and immigration-related variables. Conclusions: The findings highlight the need to consider the educational background, linguistic integration of older non-Western immigrants for the objective characterization of cognitive profiles. The results provide support for the use of the RUDAS, particularly, among older Turkish immigrants with lower educational levels and varying degrees of acculturation, bilingualism.Conference Object Event-Related Alpha and Beta Phase-Locking Decreased in Dlb and Pdd Compared To Add During the Visual Oddball Task(Elsevier, 2023) Yıldırım, E.; Yener, Görsev; Hanoglu, L.; Yılmaz, N. H.; Guntekin, B.[No abtract available]
