Exploring Free Amino Acid Profiles in Cchf Patients: Implications for Disease Progression
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Inc
Open Access Color
Green Open Access
No
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No
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Average
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Abstract
This study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease. © 2024 Wiley Periodicals LLC.
Description
Keywords
amino acid, Crimean-Congo hemorrhagic fever, LC-MS/MS, severity, alanine aminotransferase, alkaline phosphatase, amino acid, amylase, arginine, aspartate aminotransferase, creatine kinase, creatinine, ethanolamine, ferritin, gamma glutamyltransferase, glutamic acid, glutamine, histidine, immunoglobulin M, interleukin 6, lactate dehydrogenase, methionine, ornithine, phenylalanine, ribavirin, steroid, taurine, tyrosine, amino acid, biological marker, activated partial thromboplastin time, adult, amino acid metabolism, area under the curve, Article, biochemical analysis, blood clotting, controlled study, Crimean Congo hemorrhagic fever, diagnostic test accuracy study, disease exacerbation, disease severity, electrochemiluminescence, electrospray, enzyme linked immunosorbent assay, fasting blood glucose level, female, hematocrit, hemoglobin blood level, hepatomegaly, human, intensive care unit, leukocyte count, liquid chromatography-mass spectrometry, liver dysfunction, liver function test, lymphocyte count, major clinical study, male, metabolic reprogramming, multiple reaction monitoring, neutrophil count, platelet count, real time polymerase chain reaction, receiver operating characteristic, scoring system, severity grading score, virus infection, aged, liquid chromatography, metabolism, middle aged, tandem mass spectrometry, Adult, Aged, Amino Acids, Biomarkers, Chromatography, Liquid, Disease Progression, Female, Humans, Male, Middle Aged, Tandem Mass Spectrometry, Male, Adult, Tandem Mass Spectrometry, Disease Progression, Humans, Female, Amino Acids, Middle Aged, Biomarkers, Chromatography, Liquid, Aged
Fields of Science
0301 basic medicine, 0303 health sciences, 03 medical and health sciences
Citation
WoS Q
Q1
Scopus Q
Q1
OpenCitations Citation Count
N/A
Source
Journal of Medical Virology
Volume
96
Issue
5
Start Page
End Page
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CrossRef : 1
Scopus : 1
PubMed : 1
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