Oz, DidemOzbek, YagmurKiyi, IlaydaOzturk, Bilge TargitayOztura, IbrahimYener, Görsev2023-06-162023-06-1620222636-865Xhttps://doi.org/10.4103/nsn.nsn_185_21https://hdl.handle.net/20.500.14365/2628Background:Depression is common among elderly and middle-aged individuals and is a reason for decreased quality of life. Depression may lead to impairments in cognitive abilities. The P300 potential is one of the most used event-related potentials (ERPs) to evaluate cognition. This study investigated the P300 amplitude differences between individuals with depressive symptoms and nondepressed healthy elderly individuals. Materials and Methods:The current study included twenty individuals with high depression scores (high DS, age: 64.80 +/- 7.22, 6 M/14 F) and twenty demographically matched participants with low depression scores (low DS, age: 64.20 +/- 6.21, 7 M/13 F). The Geriatric Depression Scale (GDS) was used to evaluate whether participants have depressive symptoms. All of the participants were underwent a comprehensive neuropsychological battery. The ERPs were recorded with a visual classical oddball paradigm. The P300 amplitudes were measured in the 250-550 ms time window. Results:High DS group had lower P300 amplitudes than low DS individuals regardless of electrode location. Correlation analyses showed that there was a significant correlation between GDS scores and the P300 amplitudes recorded from the F-z electrode. Conclusion:The current study showed the reduced P300 amplitudes on individuals with high GDS scores. The P300 potential may be a useful tool to determine possible changes or impairments due to subthreshold depressive symptoms.eninfo:eu-repo/semantics/openAccessDepressive symptomsevent-related potentialhealthy individualsP300Event-Related PotentialsP300 LatencyOlder-AdultsRisk-FactorDementiaSymptomsDeclineArticle10.4103/nsn.nsn_185_212-s2.0-85170239093