Hunerli-Gunduz, DuyguIsbitiren, Yagmur OzbekUzunlar, HakanCavusoglu, BerrinColakoglu, Berril DonmezAdag, EmelYener, Görsev2023-06-162023-06-1620230197-45801558-1497https://doi.org/10.1016/j.neurobiolaging.2022.10.001https://hdl.handle.net/20.500.14365/1351Parkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive im-pairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to re-flect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants us-ing visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysio-logical, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological ab-normalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atro-phy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI. (c) 2022 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessParkinson?s diseaseMild cognitive impairmentEvent-relatedOscillationPowerPhaseVolumetric MRIBasal gangliaBrain OscillationsGray-MatterSubcortical AtrophyDiagnostic-CriteriaVentricular ChangesTheta-OscillationAlpha-OscillationWavelet AnalysisResponsesEegArticle10.1016/j.neurobiolaging.2022.10.0012-s2.0-85142003545