Sımsır, Ilgın YıldırımTanigor, GokselKarabulut, GoncaBarutcuoglu, BurcuYılmaz, Zevcet2024-10-252024-10-2520241303-829X1303-829Xhttps://doi.org/10.1515/tjb-2023-0273https://hdl.handle.net/20.500.14365/5554https://search.trdizin.gov.tr/en/yayin/detay/1359172/25-hydroxyvitamin-d-levels-in-sjogrens-syndrome-is-it-the-right-time-to-dismiss-the-case-or-notObjectives: This study aimed to investigate whether patients with primary Sjögren syndrome (SjS) have different levels of 25 OH-D3 (vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Methods: Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 nmol/L or ≥50 nmol/L). The disease activity was evaluated using The EULAR SjS disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. Results: No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correla- tions were found between patient characteristics or labo- ratory values (p>0.05). Conclusions: This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.eninfo:eu-repo/semantics/openAccess25 OH-D3 LevelsDisease ActivitySjögren SyndromeVitamin DPrimary Sjögren's-SyndromeVitamin-D LevelsDisease-ActivityAssociationDeficiencyEssdaiArticle10.1515/tjb-2023-02732-s2.0-85205147173