Erata, Mehmet C.Eroğlu, SedaÖzkul, BurcuUslu, ÖzgülErdoğan, YiğitKitiş, ÖmerGönül, Ali Saffet2023-10-272023-10-2720221300-06671309-4866https://doi.org/10.29399/npa.28318https://hdl.handle.net/20.500.14365/4883Introduction: Low self-esteem is a known risk factor for mental illnesses. Neuroimaging studies have identified evidence for a functional association between default mode network (DMN) and self-esteem levels. However, it is not clear whether there is a similar association between trait self-esteem and the structures composing DMN. This study aimed to investigate the relationship between the DMN associated brain structures and trait self-esteem. Methods: We obtained 3T structural magnetic resonance imaging (MRI) data of 75 healthy subjects and detected anatomical regions correlated with their Rosenberg Self-Esteem scores via voxel-based morphometry (VBM). Results: We found positive associations between self-esteem and regional grey matter volumes in the right temporoparietal junction/ inferior parietal lobule (BA 39), cortical midline regions at precuneus/ dorsal cingulate cortex (BA 31), rostral and dorsal anterior cingulate cortices (BA 32). Conclusion: The results of the current study support the fMRI studies suggesting self-esteem levels associated with DMN. Further neuroimaging studies should consider the functional and structural coupling of the default mode network during the execution of the functions related to self-esteem.eninfo:eu-repo/semantics/openAccessDefault mode network (DMN)DSM-5structural MRItemporoparietal junction (TPJ)trait self-esteemvoxel-based morphometry (VBM)MetaanalysisDepressionArticle10.29399/npa.283182-s2.0-85168549189