Duyar, HalilPortakal, Hüseyin SaygınYalcin, ErginKanat, BeyzaDoluca, OsmanSeferoglu, Zeynel2023-06-162023-06-1620210960-894X1464-3405https://doi.org/10.1016/j.bmcl.2021.127824https://hdl.handle.net/20.500.14365/1085The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.eninfo:eu-repo/semantics/closedAccessFluoreneFluorenoneG-Quadruplexc-mycLight-up probeArticle10.1016/j.bmcl.2021.1278242-s2.0-85100316635