Kocabas, UmutErgin, IsilYavuz, VeyselMurat, SeldaÖzdemir, İbrahimGenç, ÖmerAltın, Cihan2023-06-192023-06-1920231016-51691308-4488https://doi.org/10.5543/tkda.2022.98455https://search.trdizin.gov.tr/yayin/detay/1169237https://hdl.handle.net/20.500.14365/4717Objective: Oral anticoagulant therapy is the cornerstone of atrial fibrillation management to prevent stroke and systemic embolism. However, there is limited real-world information regarding stroke and systemic embolism prevention strategies in patients with atrial fibrillation. The aim of the ROTA study is to obtain the real-world data of anticoagulant treatment patterns in patients with atrial fibrillation. Materials and Methods: The ROTA study is a prospective, multicenter, and observational study that included 2597 patients with atrial fibrillation. The study population was recruited from 41 cardiology outpatient clinics between January 2021 and May 2021.Results: The median age of the study population was 72 years (range: 22-98 years) and 57.4% were female. The median CHA2DS2-VASc and HAS-BLED scores were 4 (range: 0-9) and 1 (range: 0-6), respectively. Vitamin K antagonists and direct oral anticoagulants were used in 15.9% and 79.4% of patients, respectively. The mean time in therapeutic range was 52.9% for patients receiving vitamin K antagonists, and 76% of those patients had an inadequate time in therapeutic range with <70%. The most common prescribed direct oral anticoagulants were rivaroxaban (38.1%), apixaban (25.5%), and edoxaban (11.2%). The rate of overuse of vitamin K antagonists and direct oral anticoagulants was high (76.1%) in patients with low stroke risk, and more than one-fourth of patients on direct oral anticoagulant therapy were receiving a reduced dose of direct oral anticoagulants. Among patients who were on direct oral anticoagulant treatment, patients with apixaban treatment were older, had higher CHA2DS2- VASc and HAS-BLED scores, and had lower creatinine clearance than the patients receiving other direct oral anticoagulants.Conclusions: The ROTA study provides important real-world information about anticoagulant treatment patterns in patients with atrial fibrillation.eninfo:eu-repo/semantics/openAccessAtrial fibrillationanticoagulationdirect oral anticoagulantsstrokesystemic embolismAntagonist Oral AnticoagulantsStroke PreventionEuropean-SocietyWarfarinGuidelinesManagementOutcomesAdherenceArticle10.5543/tkda.2022.984552-s2.0-85150311273