Demir, BilginDemirci, BuketTataroglu, CantenBarutca, SabriBarutca, Duygu2024-01-262024-01-2620241556-95271556-9535https://doi.org/10.1080/15569527.2023.2300790https://hdl.handle.net/20.500.14365/5131ObjectiveChemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.Material and MethodsDocetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.ResultsIn the first stage of this study, alopecia was successfully developed by DTX (10 mg/kg/three times) application. In the second stage of the study, application of HDDPiW-jSB solution, did not change the study parameters significantly on control group. The solution improved the anagen hair follicle count and Bcl-2 levels in the skin samples of DTX-induced alopecic rat groups, especially when applied twice weekly. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.ConclusionTopical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.eninfo:eu-repo/semantics/openAccessChemotherapy induced alopeciadocetaxelhair lossoncologyanimal researchHair-FolliclesChemotherapyDoxorubicinApoptosisGrowthMiceArticle10.1080/15569527.2023.23007902-s2.0-85181521620