Ayna Duran, Gizem2024-07-212024-07-2120241309-4483https://doi.org/10.52142/omujecm.41.2.23https://hdl.handle.net/20.500.14365/5413Easy-to-apply liquid biopsy technique and detection of differentially expressed miRNA/lncRNAs (DEGs) may be more beneficial in multiple myeloma (MM) compared to bone marrow (BM) biopsy. We compared the gene expression levels of circulating tumor cells and BM cells in MM patients and showed differentially upregulated circulating tumor cell-derived miRNAs and lncRNAs. DEGs and related biological pathways were identified by using the R-LIMMA package, ShinyGO 0.77, and LncSEA2.0 tools. Three hundred nine lncRNAs/16 miRNAs were detected as differentially upregulated in MM patients’ circulating tumour cells. Among them, miRNAs (mainly has-miR-103a) and lncRNAs (MEG3, NEAT1, PCAT1) were detected, and only a few miRNAs and lncRNAs were related to MM in a limited number of studies. Drugs that interact with these lncRNAs were also identified. The fact that miRNAs/lncRNAs related to MM are also detected in tumor circulating cells indicates that a technically easier liquid biopsy may verify and even replace BM biopsy. © 2024 Ondokuz Mayis Universitesi. All rights reserved.eninfo:eu-repo/semantics/closedAccessCirculating tumour cellsDEGslncRNAsmiRNAmultiple myeloma17aagantineoplastic agentcisplatincrizotinibdovitiniberlotinibirinotecanl 685458lapatiniblong untranslated RNAmaternally expressed gene 3microRNAmicroRNA 103amicroRNA 1180microRNA 133a 1microRNA 15amicroRNA 210microRNA 3618microRNA 372microRNA 429microRNA 4680microRNA 4751microRNA 4775microRNA 548nmicroRNA 6829microRNA 6883microRNA 934mirdametinibnuclear paraspeckle assembly transcript 1paclitaxelpalbociclibpanobinostatprostate cancer associated transcript 1rebemadlinRNAsaracatinibselumetinibsorafenibtanespimycintopotecantumor markerunclassified drugArticlebone marrow biopsycirculating tumor cellcontrolled studydifferential gene expressiongene expression levelhumanmajor clinical studymultiple myelomaprotein targetingupregulationArticle10.52142/omujecm.41.2.232-s2.0-85197659272