Benvenuto, DomenicoBenedetti, FrancescaDemir, Ayse BanuCiccozzi, MassimoZella, Davide2023-06-162023-06-1620210009-31571421-9794https://doi.org/10.1159/000515342https://hdl.handle.net/20.500.14365/2158Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy. Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID. Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein. Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.eninfo:eu-repo/semantics/openAccessBioinformaticCoronavirus disease 2019Evolutionary analysisProtein modelingSyndrome coronavirus 2Multiple Sequence AlignmentDeletionArticle10.1159/0005153422-s2.0-85103314146