Özkul, YılmazCiğer, EjderBalci, Mustafa KorayKılavuz, Ahmet ErdemBayrak, FedaSongu, Muratİşlek, Akif2023-06-192023-06-1920232231-37960973-7707https://doi.org/10.1007/s12070-023-03706-4https://hdl.handle.net/20.500.14365/4662Aims: This study aims to make a comparative analysis of disease-free survival (DFS) and overall disease-specific survival (OS) in patients with laryngeal carcinoma. Materials and methods: The study was designed retrospectively. Sixteen patients with postoperative PSM and 30 with negative surgical margins (NSM) were included. Survival analysis and Long-Rank comparisons was performed for DFS and OS between groups. Results: PSM was a significant independent risk factor for loco-regional recurrence and disease-related mortality (p = 0.004, HR: 1.6, p = 0.002, HR: 3.2, respectively). DFS and OS were significantly longer in NSM group (p = 0.001 and 0.003, respectively). For PSM group, 2- and 5-year DFS rates were 57%; OS rates were 80% and 34% respectively. In NSM group, 2- and 5-year DFS rates were 96% and 83%; OS rates were found to be 96%. Conclusion: PSM had significant relation with poor prognosis.eninfo:eu-repo/semantics/closedAccessLaryngeal carcinomaSurgical marginRecurrenceSurvivalPrognosisSquamous-Cell CarcinomaPostoperative RadiotherapyRadiation-TherapyPrognostic ValueNeck DissectionHeadIrradiationCancerTumorArticle10.1007/s12070-023-03706-42-s2.0-85150612019