Feyzioğlu Demir, Esra
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Feyzioglu-Demir, Esra
Feyzioglu, Esra
Feyzioglu, E.
FEYZİOĞLU-DEMİR, Esra
Feyzioğlu-Demir, Esra
FEYZIOGLU DEMIR, Esra
Feyzioglu Demir, Esra
Demir, Esra Feyzioğlu
Feyzioglu, Esra
Feyzioglu, E.
FEYZİOĞLU-DEMİR, Esra
Feyzioğlu-Demir, Esra
FEYZIOGLU DEMIR, Esra
Feyzioglu Demir, Esra
Demir, Esra Feyzioğlu
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Email Address
esra.feyzioglu@ieu.edu.tr
Main Affiliation
15.06. Medical Laboratory Techniques
Status
Current Staff
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WoS Researcher ID
Sustainable Development Goals
5
GENDER EQUALITY
0
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
13
CLIMATE ACTION
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
14
LIFE BELOW WATER
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
1
NO POVERTY
0
Research Products
2
ZERO HUNGER
0
Research Products
4
QUALITY EDUCATION
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
3
GOOD HEALTH AND WELL-BEING
1
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
15
LIFE ON LAND
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
Documents
15
Citations
163
h-index
7
Documents
14
Citations
128
Scholarly Output
11
Articles
8
Views / Downloads
12/119
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
66
Scopus Citation Count
79
WoS h-index
6
Scopus h-index
6
Patents
0
Projects
0
WoS Citations per Publication
6.00
Scopus Citations per Publication
7.18
Open Access Source
2
Supervised Theses
0
| Journal | Count |
|---|---|
| Journal of Bıomaterıals Scıence-Polymer Edıtıon | 2 |
| Polymer Bulletin | 2 |
| Polymer Bulletın | 1 |
| Polymer-Plastıcs Technology And Materıals | 1 |
| Separatıon Scıence And Technology | 1 |
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11 results
Scholarly Output Search Results
Now showing 1 - 10 of 11
Article Citation - WoS: 11Citation - Scopus: 13Mannose Based Polymeric Nanoparticles for Lectin Separation(Taylor & Francis Inc, 2018) Demir, Esra Feyzioglu; Atay, Nevra Ozturk; Koruyucu, Meryem; Kok, Gokhan; Salman, Yesim; Akgol, SinanThe aim of this work is to synthesize the original, new polymeric nanoparticles for concanavalin A (Con A) purification. Nanoparticles were synthesized by surfactant free emulsion polymerization. In the polymerization prosedure, 1-O-(2'-hydroxy-3'-acryloyloxypropyl)-2,3:5,6-di-O-isopropylidene-alpha-D-mannofuranose (Man-OPA) was used as co-monomer and 2-hydroxyethylmethacrylate (HEMA) was used as a monomer. Man-OPA was characterized by Fourier Transform Infrared Spectroscopy (FTIR), nuclear magnetic resonance and elemental analysis techniques. Poly(HEMA-Man-OPA) nanoparticles were characterized by scanning electron microscopy, FTIR and Zeta Sizer. In adsorption-desorption experiments, maximum Con A adsorption capacity of poly(HEMA-Man-OPA) nanoparticles was found 630.6 mg/g nanoparticle (pH 7.5, 1.0 mg/mL). Adsorption-desorption experiments were repeated in four times. According to results, these nanoparticles could be used several times without significant decrease in Con A adsorption capacity.Article Citation - WoS: 7Citation - Scopus: 11The Effect of Virtual Laboratory Simulations on Medical Laboratory Techniques Students' Knowledge and Vocational Laboratory Education(Walter De Gruyter Gmbh, 2022) Keles, Didem; Bulgurcu, Alihan; Demir, Esra Feyzioglu; Şemin, Makbule İlgiObjectives Virtual laboratory simulations (VLSs) are computer-based tools that offer unlimited application options in scientific, medical, and engineering fields. The aim of this study was to evaluate whether VLSs are efficient learning tools and how these simulations can be integrated into laboratory practice in medical laboratory education. Methods In this pre-test/post-test control group study, 32 volunteers were randomly assigned to either experimental or control groups. The experimental group performed laboratory simulations based on biochemistry and microbiology and then completed a self-report survey to evaluate their satisfaction and beliefs about simulations. Results In the experimental group, post-test scores of each simulation were significantly elevated compared to pre-test scores; however, pre- and post-test scores of control group were statistically the same. The experimental group agreed that these simulations should be applied before theoretical lectures and laboratory practices. They also highlighted that translating from English to their native language creates difficulties in applying and understanding the simulation. Conclusions We emphasized that VLSs are excellent learning tools that increase not only the knowledge but also the self-motivation and focus of the students. Based on feedbacks, native language options are necessary to enable the students to achieve equality of opportunity in education.Article Citation - WoS: 6Citation - Scopus: 6New Insight Into Anti-Wrinkle Treatment: Using Nanoparticles as a Controlled Release System To Increase Acetyl Octapeptide-3 Efficiency(Springer, 2023) Bağlamış, Selami; Feyzioğlu-Demir, Esra; Akgöl, SinanBotulinum neurotoxins represent a revolution in cosmetic science because of their extraordinary and long-term anti-wrinkle properties. Nevertheless, high neurotoxicity severely limits their usage. Therefore, design and validation of new non-toxic molecules which mimics the Botox are needed. Here, acetyl octapeptide-3 is used which mimics the effect mechanism of botulinum neurotoxin to reduces the depth of wrinkles, was chosen as an alternative molecule. Glutamic acid containing poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid) [p(HEMAG)] nanoparticles were synthesized for controlled release of acetyl octapeptide-3 to increase the efficiency on the related area. Scanning electron microscopy and atomic force microscopy were used to state the morphological characteristics of the synthesized nanoparticles, and the Fourier transform infrared was used to characterize chemical structures; additionally, the dimensional analysis was carried out by using a zeta-sizer device, and then, characterized nanoparticles were used for loading acetyl octapeptide-3. Time, pH, ionic strength, temperature and concentration experiments were performed to optimize the adsorption conditions of the acetyl octapeptide-3 to the nanoparticles. The maximum acetyl octapeptide-3 adsorption capacity onto nanoparticles was found 220.69 mg/g. The pH and temperature experiments were carried out to follow-up the release conditions of acetyl octapeptide-3-loaded nanoparticles. Lastly, cytotoxicity tests were done by using Alamar Blue method and Lactate Dehydrogenase (LDH) Assay. Our results imply that the developed nanocosmetic material is non-toxic, efficient and cost-effective and it is promising to use in anti-wrinkle treatment.Article Citation - WoS: 11Citation - Scopus: 13Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes(Taylor & Francis Ltd, 2018) Demir, Esra Feyzioglu; Kuru, Cansu Ilke; Uygun, Murat; Uygun, Deniz Aktas; Akgol, SinanHerein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10.85 mol/g and 3.52 mg/g, respectively. Optimum conditions for IgG adsorption such as adsorption capacity, pH and reusability profile of HMs were judiciously characterized. Maximum IgG adsorption capacity of hydrogel membrane was found to be as 26.81 mg/g. Adsorbed IgG was eluted successfully by using 2.0 M of NaCl solution. Reusability profiles of hydrogel membrane in five adsorption-desorption cycles revealed that there was no significant decrease in IgG adsorption capacity at the end of the 5th reuse. The hydrogel membranes reported here hold considerable promise as an effective sorbent system for IgG adsorption with good stability and efficient repeated usage.Article Citation - WoS: 8Citation - Scopus: 7Swelling and Diffusion Behaviour of Spherical Morphological Polymeric Hydrogel Membranes (smphms) Containing Epoxy Groups and Their Application as Drug Release Systems(Springer, 2023) Feyzioglu-Demir, Esra; Uzum, Omer Baris; Akgol, SinanThe aim of the study is to characterize synthesized spherical morphological polymeric hydrogel membranes (SMPHMs), especially their swelling properties, and to show the usability of these SMPHMs in the biomedical applications such as drug delivery systems. Insulin used in the treatment of diabetes mellitus disease was chosen as a model drug to demonstrate the usability of these SMPHMs as a drug delivery system. For this purpose, poly(hydroxyethyl methacrylate-co-glycidyl methacrylate) [P(HEMA-GMA)] SMPHMs were prepared by photopolymerization technique using different monomers mole ratios. Characterization of SMPHMs was carried out with SEM and FTIR analyses. Swelling experiments were conducted in water. Equilibrium percentage swelling values of SMPHMs were calculated and found as in the range of 40-122%, depending on hydrophilic structure of SMPHMs. Swelling kinetic parameters were determined, and the diffusion behaviour of water was also investigated. Water diffusion into the SMPHMs was found to shift from non-Fickian diffusion to Fickian diffusion when HEMA/GMA mole ratio was decreased in the structure of SMPHMs. In the final part of study, insulin release conditions from SMPHMs were optimized. For this purpose, insulin release studies were carried out to investigate the effect of monomer ratios, pH, temperature, and initial insulin concentration. The amount of maximum cumulative insulin release was found as 3747.73 mu g/g in pH 7.4, at 25 degrees C, in the 0.5 mg/mL insulin concentration from SMPHMs-3 in seven hours. According to these obtained results, these SMPHMs can be used as alternative systems for biotechnological applications such as swelling-controlled drug delivery systems.Book Part Citation - Scopus: 1Sustainable Wastewater Management(American Chemical Society, 2025) Öztürk Atay, N.; Feyzioğlu-Demir, E.Access to safe and clean water is at risk as water resources and quality are being depleted due to industrialization, urbanization, population growth, climate change and agricultural practices. Pollutants in wastewater with a high potential to harm nature, humans and the entire ecological system are contaminating clean water resources such as groundwater, seas, lakes and streams, causing water pollution. Therefore, wastewater management is crucial to the safety and sustainability of all water systems. In efforts to ensure cleaner and safer water, wastewater treatment is a key element in sustainable management of wastewater. In addition, it is necessary to use wastewater from a range of different sources in production management to promote sustainability. This book section contains a discussion of wastewater treatment techniques for sustainable management of wastewater and issues related to resource recycling from wastewater. © 2025 American Chemical SocietyBook Part Novel Adsorbents for Sustainable Water Management(Institute of Physics Publishing, 2025) Öztürk-Atay, N.; Feyzioğlu-Demir, E.Book Part Citation - Scopus: 1Adsorption and Removal of Contaminants Using Molecularly Imprinted Polymers(Springer Nature, 2024) Feyzioğlu Demir, Esra; Atay, N.Ö.Environmental pollution is an increasing problem, and is an important issue for environmental sustainability. For a sustainable environment, it is necessary to use the natural content of soil, water and air without disturbing it. The removal of pollutants in soil, water and air are necessary in this respect. Many methods are used to remove pollutants from the environment. One of these is adsorption with molecularly imprinted polymers (MIPs). MIPs can recognize the targeted molecules by size, shape, and functional groups, and have selective binding properties with covalent or non-covalent bonds. Thus, pollution can be removed by specific MIPs. They represent a cost effective, easy-to-apply, reusable and environmentally-friendly method of removing pollution. Pollution can be rapidly removed from the water or soil without the creation of by-products. MIPs can be prepared in different forms, such as micro- or nano-sized spherical particles and membranes, depending on the intended use. In this chapter, the important role of MIPs in environmental applications will be emphasized, particularly in the removal of the various organic and inorganic highly-polluting wastes, such as metal ions, dyes, drugs, and pesticides. The current studies on these issues will be reviewed and discussed. © Springer Nature Switzerland 2024.Article Citation - WoS: 18Citation - Scopus: 21Synthesis and Characterization of Albumin Imprinted Polymeric Hydrogel Membranes for Proteomic Studies(Taylor & Francis Ltd, 2018) Demir, Esra Feyzioglu; Ozcaliskan, Emir; Karakas, Hayriye; Uygun, Murat; Uygun, Deniz Aktas; Akgol, Sinan; Denizli, AdilIn this presented study, a novel molecularly imprinted polymeric hydrogel membranes (PHMs) were developed to use for the albumin depletion studies. For this, albumin imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-phenylalanine methyl ester) polymeric hydrogel membranes [p(HEMA-MAP) PHMs] were synthesized by the photopolymerization technique, and then characterized by SEM, EDX, FT-IR and swelling studies. Synthesized PHMs had spherical structure and the MAP monomer incorporation onto the PHMs was determined by EDX analysis by using nitrogen stoichiometry. Also, the swelling ratio of the albumin imprinted p(HEMA-MAP) PHMs was determined as 215%. The optimum albumin adsorption condition (adsorption capacity, medium pH, adsorption rate, temperature, ionic strength) were studied and the maximum albumin adsorption capacity was found to be as 34.28mg/g PHMs. Selectivity experiments were also carried out with the presence of the competitive proteins such as lysozyme and amylase, and the results demonstrated that the albumin imprinted p(HEMA-MAP) PHMs showed high affinity towards the BSA molecules than the competitive proteins of lysozyme and amylase. Adsorbed albumin was desorbed from the PHMs by 1.0M of NaCl, and the reusability of the imprinted PHMs was also demonstrated for five successive adsorption-desorption cycles without any significant loss in the albumin adsorption capacity. As an application, sodium-dodecyl sulfate polyacrylamide gel electrophoresis was used to indicate the albumin depletion efficiency of albumin imprinted p(HEMA-MAP) PHMs. This presented study showed that, these imprinted membranes are promising for proteomic studies and applications, and can be used for the investigations for human diagnostics.Article Citation - WoS: 1Investigation of Controlled Salmeterol Xinafoate and Fluticasone Propionate Release From Double Molecular Imprinted Nanoparticles(Springer, 2024) Feyzioğlu-Demir, Esra; Akgol, SinanSalmeterol xinafoate (SAM) and fluticasone propionate (FLU) are one of the drug combinations used together in the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). The aim of this study is to investigate the usability of novel dual molecular imprinted nanoparticles (poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-alanine-N-methacryloyl-(L)-histidine) [p(HEMA-MAAL-MAH)], abbr. DMIPNPs) as a controlled drug release systems. In this study, SAM and FLU drugs were chosen as model drugs because they are used in the treatment of these diseases. DMIPNPs were prepared by surfactant-free emulsion polymerization method and characterized by scanning electron microscopy (SEM) and fourier transform infrared spectrometer (FTIR). In in vitro drug release experiments, drug release conditions were optimized. SAM and FLU release from DMIPNPs experiments were also performed in the simulated lung fluid (SLF). The amount of released SAM and FLU were found as 4.79 and 5.68 mg/g in the SLF medium at the end of 48 h, respectively. The release kinetics of SAM and FLU from DMIPNPs were calculated in the SLF medium. The release of SAM and FLU was determined to be compatible with the Higuchi release models. According to these results, these DMIPNPs, dual-template molecular imprinted nanoparticles with dual monomers, are promising materials that can be used in the controlled release of two different drugs.
