Süer, Özge

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Profile URL
https://hdl.handle.net/20.500.14365/7114
Name Variants
Sür, Özge
Suer, Ozge
Job Title
Email Address
ozge.suer@ieu.edu.tr
Main Affiliation
05.07. Food Engineering
Status
Current Staff
Website
ORCID ID
0000-0002-8120-6574
Scopus Author ID
57763018600
Turkish CoHE Profile ID
E5D8BA59086EC29A
Google Scholar ID
ve7NAIgAAAAJ
WoS Researcher ID
GNP-2201-2022
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Ozge_Suer.jpg (11.3 KB)

Sustainable Development Goals

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2

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2

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0

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0

WoS Citation Count

8

Scopus Citation Count

8

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2

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2

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0

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4.00

Scopus Citations per Publication

4.00

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1

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  • Thumbnail Image
    Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Adjuvant Action of Needle-Shaped Bc Microfibrils
    (Springer, 2023) Sür, Özge; Gül, Aytul; Hames, Elif Esin; Süer, Özge
    Bacterial cellulose (BC) is an unbranched biopolymer produced by microorganisms and composed of glucopyranose units linked by beta-1,4 bonds. This study investigates the adjuvant action of needle-shaped BC microfibrils (BCmFs) in vitro using bovine serum albumin (BSA) as a model antigen. BC produced by the static culture of Komagataibacter xylinus was then microparticled (1-5 mu m) by acid hydrolysis and characterized using Dynamic Light Scattering and Scanning Electron Microscopy. Subsequently, Attenuated Total Reflectance-Fourier-Transform Infrared Spectroscopy, cytotoxicity, TNF-alpha (tumour necrosis factor-alpha) and IL-6 (interleukin-6) cytokine secretion, and cellular uptake of the BCmFs-BSA conjugate on the human monocyte cell line (U937) differentiated into macrophages were performed. The microfibrils were determined to be 1-5 mu m in size, needle-shaped, with a zeta potential of - 32 mV. Their conjugation with the model antigen, BSA, was demonstrated by FTIR analysis. In the cytotoxicity assay, BCmFs-BSA in macrophage cells showed high viability (over 70%). Although the highest TNF-alpha cytokine level (113 pg/ml) was obtained with BCmFs-BSA (Bovine serum albumin) conjugate (500 mu g/ml) and was statistically significant (p = 0.0001) compared to the positive control group (BSA-aluminium hydroxide), IL-6 cytokine levels were not statistically different from those in the control group as desired. It has been shown in macrophage-differentiated U937 cells that microbially synthesized BC in the form of needle-shaped microfibrils (BCmFs) has a high cellular uptake capacity and increases the immunogenicity of the antigen. These results demonstrate for the first time that BCmFs have the potential to serve as a vaccine adjuvant.
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    Article
    Citation - WoS: 6
    Citation - Scopus: 6
    Synthesis of Upconverting Nanosheets Derived From Er-Yb and Tm-Yb Co-Doped Layered Perovskites and Their Layer-By Assembled Films
    (Elsevier, 2022) Gunay, Bensu; Suer, Ozge; Doger, Hilal; Arslan, Ozlem; Unal, Ugur; Saglam, Ozge
    Here, we investigated the structure and upconversion (UC) properties of new-type of single oxide nanosheets, derived from the Er3+/Yb3+ and Tm3+/Yb3+ co-doped Ruddlesden-Popper type layered perovskites, and their layer-by-layer (LBL) self-assembled nanofilms. The single oxide nanosheets, obtained by exfoliation of the proton-exchanged K2La2Ti3O10, had the thickness in the range of 2-3 nm indicating good consistency with the theoretical thickness and lateral size from 500 nm up to 2 mu m. Er3+/Yb3+, Tm3+/Yb3+ and Tm3+/Er3+co-doped nanosheets were used as building blocks of the multilayer films deposited by layer-by-layer procedure. The LBL films composed of 2.5 % Er3+ + 5 % Yb3+, 2.5 % Tm3+ + 20 % Yb3+, 2.5 % Tm3+ + 20 % Er3+ after 60 sequences have shown a white emission confirmed by the CIE chromaticity diagram. The possible UC energy transfer of LBL films fabricated after 30 sequences using the nanosheets derived from the 2.5 % Er3+ + 5 % Yb3+ co-doped layered perovskites was also suggested. The number of photons participating in the UC process was confirmed as two-photon for both green and red UC emissions due to the F-4(9/2) -> I-4(15/2) and H-2(11/2), S-4(3/2) -> I-4(15/2) transitions, respectively.