Seval Çelik, Yasemin

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https://hdl.handle.net/20.500.14365/6699
Name Variants
SEVAL CELIK, Yasemin
Celik, Seval Yasemin
Çelik, Yasemin Seval
Seval-Celik, Y.
Seval Celik, Yasemin
Seval-Celik, Yasemin
Şeval-Çelik, Yasemin
Seval, Y
Seval, Y.
Seval, Yasemin
Job Title
Email Address
yasemin.celik@ieu.edu.tr
Main Affiliation
09.01. Basic Medical Sciences
Status
Current Staff
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ORCID ID
0000-0002-6516-6285
Scopus Author ID
57201321460
Turkish CoHE Profile ID
3F00F96DE98657A1
Google Scholar ID
s9nXy-IAAAAJ
WoS Researcher ID
IQS-9427-2023
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Yasemin_Seval_Celik.png (71.7 KB)

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Acta Neurobıologıae Experımentalıs1
Acta Physıologıca1
INJURY-International Journal of the Care of the Injured1
Journal of Histochemistry & Cytochemistry1
Reproductıve Scıences1
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Now showing 1 - 7 of 7
  • Thumbnail Image
    Article
    Effects of Varenicline as an Adjunct to Analgesic and Anti-Inflammatory Therapy in Acute Nerve Injury
    (Elsevier Sci Ltd, 2026) Ozturk, Volga; Rusen, Yasemen Adali; Ertener, Ozge; Seval-Celik, Yasemin; Dastan, Ali Engin; Ozgenc, Serhat; Baris, Elif
    Introduction: Acute nerve injury (ANI) leads to significant neuropathic pain and functional impairment. Current treatments, including nonsteroidal anti-inflammatory drugs (NSAIDs) like meloxicam, provide symptomatic relief but have limited neuroregenerative effects. Varenicline, a nicotinic acetylcholine receptor (nAChR) agonist, has demonstrated neuroprotective and anti-inflammatory properties. Aim: This study evaluates the effects of varenicline as an add-on therapy to meloxicam in a rat model of ANI. Methods: Eighteen female Wistar rats were randomized into four groups: Control (CONT), Sham (SHAM), Acute Nerve Injury + Meloxicam (ANI+Melox), and Acute Nerve Injury + Meloxicam + Varenicline (ANI+Melox+VAR). Varenicline (2.5 mg/kg, s.c.) was administered alongside meloxicam (2 mg/kg, s.c.). Functional recovery, histopathological changes, and biochemical markers, including prostaglandins (PGE2, PGI2), substance P, IL-6, levels, were assessed after 30 days. Results: Varenicline and meloxicam co-treatment significantly reduced inflammatory and pain biomarkers including prostaglandins, interleukin-6 and substance P, compared to meloxicam alone. Histopathological evaluation revealed enhanced Schwann cell proliferation, reduced fibrosis, and increased Bands of B & uuml;ngner formation, suggesting nerve regeneration. Conclusion: Varenicline, as an adjunct to meloxicam, enhances neuroprotection, reduces inflammation, and promotes histological and biochemical indicators of regeneration in rats with acute sciatic nerve injury. Future studies should explore its long-term effects and potential as a monotherapy for peripheral nerve injuries.
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    Conference Object
    Investigation of the Effect of Repeated Acetaminophen Usage on Hippocampus, Prefrontal Cortex and Liver Igf-1 and Mmp-2 Levels in Rats
    (Wiley, 2019) Karakilic, Ash; Kizildag, Servet; Yuce, Zeynep; Seval Çelik, Yasemin; Kandis, Sevim; Bozan, Hemdem Rodi; Koc, Bazar; İnan, Sevinç
    [Abstract Not Available]
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    Article
    Repeated Acetaminophen Administration Damaged Hippocampal Tissue but Did Not Affect Prefrontal Cortex or Anxiety Behaviors
    (Nencki Inst Experimental Biology, 2022) Karakilic, Asli; Kizildag, Servet; Yuce, Zeynep; Seval Çelik, Yasemin; Kandis, Sevim; Bozan, Hemdem Rodi; Koc, Basar
    Acetaminophen is one of the most widely used over-the-counter drugs worldwide for the treatment of pain and fever. Although acetaminophen use is known to impair hippocampus-related learning and memory, its effect on anxiety is not clear. Insulin-like growth factor-1 (IGF-1) and matrix metalloproteinase-2 (MMP2) are important for cellular survival, maintenance and tissue integrity. The aim of this study was to investigate the dose-dependent effects of acetaminophen on anxiety levels as well as on hippocampus, prefrontal cortex and liver tissue. Doses of 100, 200 and 400 mg/kg acetaminophen were administered to male Sprague Dawley rats for 11 days and anxiety tests were conducted on the last day. Twenty-four hours after the last acetaminophen administration, all animals were sacrificed and hippocampus, prefrontal cortex and liver tissues were removed for analyses. Hippocampal IGF-1 and MMP2 levels were shown to decrease only at the highest dose of acetaminophen, which was accompanied by pathological changes in histology. The prefrontal cortex was not affected. Behavioral analyses also did not indicate changes in anxiety levels in the rats. Liver IGF-1 and MMP2 levels decreased in all experimental groups. Serum alanine aminotransferase and aspartate aminotransferase levels increased in the 200 mg/kg and 400 mg/kg acetaminophen groups. Our findings showed that varying doses of acetaminophen did not affect the prefrontal cortex or anxiety levels. Further research is needed to elucidate the hippocampal and hepatic protective roles of IGF-1 and MMP2 in acetaminophen toxicity and their potential use in therapeutic approaches.
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    Article
    Citation - WoS: 4
    Citation - Scopus: 4
    The Distribution of Foxp3 and Cd68 in Preeclamptic and Healthy Placentas: a Histomorphological Evaluation
    (Sage Publications Ltd, 2023) Ersoy Canillioğlu, Yasemin; Erkanlı Şentürk, Gözde; Şahin, Hakan; Şahin, Sadık; Şeval-Çelik, Yasemin
    Preeclampsia is a complication of pregnancy that affects 3-5% of pregnancies and is one of the major causes of maternal/neonatal mortality and morbidities worldwide. We aimed to investigate the distribution of Foxp3+ regulatory T-cells and CD68+ Hofbauer cells in the placenta of preeclamptic and healthy pregnant women with a special focus on correlating these findings with placental histology. Decidua and chorionic villi of the placenta obtained from healthy and preeclamptic pregnancies were evaluated in full-thickness sections. Sections were stained with hematoxylin and eosin and Masson's trichrome and immunostained for Foxp3 and CD68 for histological analyses. The total histomorphological score for placentas was found to be higher in preeclamptic placentas than that in the controls. The CD68 immunoreactivity was higher in the chorionic villi of preeclamptic placentas than that in the controls. The immunoreactivity of Foxp3 was found widely distributed within the decidua in both the groups and did not differ significantly. Interestingly, Foxp3 immunoreactivity in the chorionic villi was found mainly in the villous core and, to a lesser extent, in the syncytiotrophoblasts. We found no significant relation between Foxp3 expressions and morphological changes observed in preeclamptic placentas. Although extensive research is being carried out regarding the pathophysiology of preeclampsia, the findings are still controversial.
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    Article
    Multidisciplinary Case-Based Small Group Discussions To Integrate Basic Medical Sciences With Clinical Situations
    (Walter De Gruyter Gmbh, 2022) Şemin, Makbule İlgi; Ersil Soysal, Dilek; Seval Çelik, Yasemin; Hayran, Murvet; Demir, Ayse Banu; Ozkaya, Ali Burak; İnan, Sevinç; Akdoğan, Gül
    Objectives Integration of the basic medical sciences with clinical medicine motivates medical students by showing how the fundamental concepts they have learned will come into their future practice. In this context, we created clinical integration sessions (CIS) in our first-year medical curriculum. Methods The instructors of different disciplines wrote the clinical scenarios together. The scenarios were discussed in five sessions with 39 first-year students. The first session's scenario consisted of four brief anemia cases. The next four sessions included a single case, according to the feedback of the students. Students formed groups of 7-8 participants. In the first 2 h, the scenarios were discussed in the groups and questions were answered by the students. In the third hour, the instructors answered the questions together with the students. After the first CIS, written feedback obtained from the students via a survey. Results The survey provided positive feedback on the benefits of active learning within small group discussions, and most of the students thought that their background was sufficient to solve the cases, with some literature search. Conclusion The scenarios, which provide multidisciplinary integration of basic medical sciences and clinical medicine, can be useful educational materials.
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    Article
    Citation - WoS: 31
    Citation - Scopus: 34
    P38 Mitogen-Activated Protein Kinase Is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but Not Cell Survival
    (Sage Publications Inc, 2018) Cakmak, Hakan; Seval-Celik, Yasemin; Arlier, Sefa; Guzeloglu-Kayisli, Ozlem; Schatz, Frederick; Arici, Aydin; Kayisli, Umit A.
    Background: Local pro-inflammatory environment and enhanced cell survival contribute to the endometriosis development. A serine/threonine kinase p38 mitogen-activated protein kinase (MAPK) mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis in different cell types. The current study compares p38 MAPK activity in normal endometrium and endometriosis, and assesses role(s) of p38 MAPK on cytokine production and cell survival in endometriosis. Methods: Immunohistochemical levels of total and phosphorylated (active) p38 MAPK as well as its correlation with interleukin 8 (IL-8) expression, and cell proliferation and apoptosis were compared in normal human endometrium and endometriosis. The action of p38 MAPK on pro-inflammatory cytokine-induced IL-8 and monocyte chemotactic protein (MCP)-1 expression in endometriotic cells were assessed by enzyme-linked immunosorbent assay. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell survival, 5-bromo-2-deoxyuridine incorporation, and Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assays were used to determine the function of p38 MAPK in cultured human endometriotic stromal cell proliferation and apoptosis. Results: p38 MAPK activity was significantly higher in both eutopic and ectopic endometria compared to normal endometria during late proliferative and early secretory phases (P < .05). Increased p38 MAPK activity in endometriotic cells correlated with IL-8 expression (Pearson correlation coefficient r = 0.83, P < .01), but not with apoptosis in vivo. The pro-inflammatory cytokines IL-1 and tumor necrosis factor (TNF)- induced activation of p38 MAPK. Inhibition of p38 MAPK activity blocked IL-1 and TNF--induced IL-8 and MCP-1 secretion in cultured endometriotic stromal cells (P < .05), but did not impact on endometriotic cell survival. Conclusions: These results suggest that rather than modulating cell survival, increased p38 MAPK activity in endometriotic cells contributes to the pathogenesis of endometriosis by promoting the local inflammatory milieu.
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    Master Thesis
    İnsan Endometriyal Adenokarsinom Hücre Hattında Galektin-1 ve Galektin-3 Ekspresyonlarının Hormonal Düzenlenmesi
    (İzmir Ekonomi Üniversitesi, 2021) Abushova, Aytaj; Çelik, Yasemin Seval
    Uterin dokularda menstrual döngünün farklı evrelerinde galektinlerin ekspresyonlarının değişiyor olmasından yola çıkarak, endometriyumda eksprese edildiği bilinen galektin-1 ve galektin-3'ün ekspresyonunun ovaryan hormonlar ile düzenleniyor olabileceği hipotezi kurulmuştur. Çalışmamızda bir endometriyal adenokarsinom hücre hattı olan Ishikawa hücre hattına östradiol (E2) ve progesteronun (P4) ayrı ayrı veya birlikte verilmesi ile galektin-1 (Gal-1) ve galektin-3 (Gal-3) ekspresyonlarında mRNA ve protein düzeyinde meydana gelen değişikliklerinin belirlenmesi amaçlanmıştır. Ishikawa hücre kültürlerinde hormon dozlarına ve zamana bağlı deney grupları oluşturulmuş, hücre kültür süpernatantları toplanarak ELISA yöntemi ile salgısal Gal-1 ve Gal-3 protein miktarları, hücrelerden RNA izole edilerek gerçek zamanlı PCR yöntemi ile Gal-1 ve Gal-3 ekspresyonları değerlendirilmiştir. Çalışmanın sonucuna göre Ishikawa hücrelerinde Gal-1 ve Gal-3 mRNA ekspresyonu ve salgısal protein miktarının ovaryan hormonlarla zamana ve doza bağlı olarak değiştiği, Gal-3'te daha belirgin olmak koşuluyla hem Gal-1 hem de Gal-3 ekspresyonunun östradiole kıyasla progesterona daha duyarlı olduğu belirlenmiştir. Patogenezinde Gal-1 ve Gal-3'ün rol aldığı bilinen ve buna ek olarak özellikle de patogenezi ve prognozunu hormonların etkilediği hastalıklar ve durumlarda (ER ve PR -pozitif kanserler, endometriyozis, pre-eklampsi, spontane düşükler, infertilite vb) galektinlerin hormonlarla düzenlendiğinin göz önünde bulundurulması ve tanı/tedavi yöntemlerinin ona göre seçilmesi gerekir.