Okay, Gülin

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Profile URL
https://hdl.handle.net/20.500.14365/6961
Name Variants
Okay, Gulin
Job Title
Email Address
gulin.okay@ieu.edu.tr
Main Affiliation
09.04. Surgical Sciences
Status
Current Staff
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ORCID ID
0000-0001-6509-523X
Scopus Author ID
54971502900
Turkish CoHE Profile ID
A04CA603512D0019
Google Scholar ID
EQtkeDIAAAAJ
WoS Researcher ID
M-6515-2013

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10

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RESPONSIBLE CONSUMPTION AND PRODUCTION
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1

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7

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8

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2

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1.75

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2.00

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JournalCount
Genel Tip Dergisi1
Internatıonal Journal of Clınıcal Practıce1
İzmir Tepecik Eğitim Hastanesi Dergisi1
Medical Principles and Practice1
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Now showing 1 - 4 of 4
  • Thumbnail Image
    Article
    Insulin Resistance in Preeclampsia and Its Effect on Maternal-Fetal Outcomes
    (Selçuk University, 2025) Okay, G.; Taner, C.E.
    Aim: It is controversial whether insulin resistance and hyperinsulinemia in preeclamptic patients are due to weight gain during pregnancy or preeclampsia. This research seeks to explore the relationship between insulin resistance and factors such as weight gain, obesity, biochemical indicators, and the fetal outcomes linked to insulin resistance in pregnant women experiencing mild and severe preeclampsia, excluding those with gestational diabetes. Methods: This research was carried out in the Perinatology Department of İzmir Tepecik Training and Research Hospital from July 2013 to January 2014, with the approval of the institution’s ethics committee. Non-diabetic preeclamptic 101 pregnant women between 18 and 44 years of age in 24-40 gestational weeks were involved in the research. We recorded demographic data, biochemical parameters, weight measurements, enquiries regarding glucose metabolism, and data about fetuses. A Homeostatic Model Assessment (HOMA) value of 2.5 or above, along with an insulin sensitivity index of 6 or below, was evaluated as indicative of insulin resistance. Results: There was no remarkable variation in both groups concerning fasting and postprandial glucose level, HOMA-IR (homeostatic model assessment insulin resistance), and insulin sensitivity index. Postprandial insulin levels were significantly elevated in the group with severe preeclampsia (p < 0,05). On the other hand, when we examined the effects on fetal outcomes, delivery time, birth weight, and 1 and 5 min Apgar scores were determined to be statistically significantly lower in the group suffering from severe preeclampsia. Conclusion: In our research, it was observed that postprandial insulin levels were considerably elevated in the group with severe preeclampsia. Postprandial insulin levels can be considered to predict the impact of insulin resistance and sensitivity on disease prognosis and maternal-fetal outcomes in preeclampsia patients without gestational diabetes. Therefore, its usefulness as a parameter for predicting metabolic syndrome in later years should be investigated in large prospective randomized controlled trials. © 2025, Selcuk University. All rights reserved.
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    Article
    Citation - WoS: 2
    Citation - Scopus: 3
    Perspectives and Knowledge About Fertility Preservation Strategies Among Female Cancer Patients in Turkey
    (Wiley-Hindawi, 2023) Emirdar, Volkan; Karatasli, Volkan; Acet, Ferruh; Okay, Gulin; Gode, Funda; Karabulut, Alaattin; Arslan, Cagatay
    Objectives. To evaluate the knowledge level and perspectives of female cancer patients regarding fertility preservation techniques before gonadotoxic treatment. Material and Methods. This was a prospective observational survey-based study conducted between 2016 and 2020 in Izmir Economy University Medical Park Hospital. A total of 150 female cancer patients aged 18-42 years were included. The participants completed a 17-item questionnaire, developed by the research team to evaluate their knowledge and perspectives on fertility preservation techniques. Results. The mean age of the patients was 39.5 +/- 4.9 years. Only 64.7% of the patients were referred to fertility counseling by a gynecologist, while 72.6% of the patients knew of the risk of infertility after cancer treatment. There was a significant correlation between the health status and cancer stage of the patient (p=0.003). The estimated future chance of becoming pregnant spontaneously or through fertility preservation techniques was significantly higher in patients with a higher education level (p=0.041 or 0.008, respectively). Satisfaction with the counseling process was reported as high or low by 66.7% or 20% of the patients, respectively. Conclusions. The rate of referral of reproductive-age cancer patients to fertility preservation counseling is still not satisfactory. Education level was the only variable significantly associated with a motivation to become pregnant after cancer treatment, either spontaneously or through fertility preservation techniques.
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    Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Ganoderma Lucidum and Hypericum Perforatum Exhibit Anti-Inflammatory, Antioxidant and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome
    (Karger, 2024) Okay, Gülin; Kırıcı, Pınar; Mavral, Nihal; Utkan Korun, Zeynep Ece; Annac, Ebru; Kaplan, Selçuk
    Objective: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderma lucidum polysaccharide (GLP) and Hypericum perforatum (HP)have been reported to have anti-inflammatory and antioxidant activities. We studied the effects of these agents on ovarian tissue in a rat model of experimental PCOS. Materials and methods: Forty-two Sprague-Dawley female rats were divided into 6 groups with 7 animals in each group as listed below; Group 1: Control, Group 2: PCOS, Group 3: PCOS + HP, Group 4: HP only, Group 5: PCOS+ GLP, Group 6: GLP only. At the end of the experimental procedures, all animals underwent bilateral oophorectomy and blood samples were collected. Ovarian tissue and blood samples were used for biochemical and histopathological analysis. Results: Follicle degeneration in the PCOS group showed a statistically significant increase compared to the other groups (p<0.05). When the PCOS+GLP and PCOS+HP groups were examined, it was determined that the cystic follicles were significantly reduced compared to the PCOS group. Whereas tumor necrosis factor-alpha (TNF-a) and interleukin-6 (IL-6) levels were elevated in PCOS rats (p<0.01). Sex hormone binding globulin (SHBG) levels were diminished (p<0.01). MDA and IGF-1 levels were increased in PCOS rats as against the remaining groups (p<0.02, p<0.02, respectively). GLP supplementation to the treatment diminished IGF-1 and malondialdehyde (MDA). GLP or HP supplementation increased reduced glutathione (GSH). Conclusion: GLP and HP treatment normalizes SHBG levels while correcting PCOS-induced hyperandrogenemia. Both herbs regulate the redox balance by decreasing the MDA level and increasing the GSH.
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    Article
    Yardımcı Üreme Tekniklerinde Oosit Kriyoprezervasyonunun Günümüzdeki Yeri ve Kliniğimizde Uygulanan Oosit Dondurma Sikluslarının Değerlendirilmesi
    (2022) Göde, Funda; Sertkaya, U; Emirdar, Volkan; Pala, İbrahim; Karataşlı, Volkan; Okay, Gülin
    Amaç: Çeşitli endikasyonlar ile kliniğimizde uygulanan oosit dondurma hastaları ve sonuçlarının değerlendirilmesidir. Yöntem: Bu retrospektif araştırmaya üçüncü basamak bir hastanenin tüp bebek merkezine 2015-2020 yılları arasında başvuran, gonadotoksik tedaviler öncesi fertilite prezervasyonu uygulanan; düşük over rezervi saptanan evli olmayan kadın hastalar ve azospermi nedeniyle işlem günü eşlerinden sperm elde edilemeyen veya oosit sayısının az olması nedeniyle mikroenjeksiyon için oosit havuzlaması yapılan 18-48 yaş arası kadın hastaların oosit dondurma siklusları ve sonuçları değerlendirildi. Bulgular: Farklı endikasyonlar ile başvuran 224 kadın hastanın yapılan kontrollü ovaryen stimülasyon sonrası oosit dondurma sikluslarından elde edilen verilere göre oosit canlılık oranı %92,68, çözme siklusu başına gebelik oranı %8,66, çözme siklusu başına canlı doğum oranı ise %4,66 olarak bulundu. Sonuç: Klinik uygulamalarda yerini almış olan oosit kriyoprezervasyon sikluslarında dondurma-çözme sonrası oosit sağkalım oranları vitrifikasyon ile oldukça yüksek saptanmış olup; bu oositler ile elde edilen gebelik ve canlı doğum oranları, embriyo dondurma-çözme oranlarına yakın bulunmuştur. Vitrifikasyon tekniklerindeki gelişmeler ile yüksek canlılık ve başarı oranları yakalanan oosit dondurma-çözme uygulamalarının endikasyonlar dahilinde yardımcı üreme tekniklerinde daha güçlü bir yer alacağı düşünülmektedir.