Doğduş, Mustafa
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Dogdus, Mustafa
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mustafa.dogdus@ieu.edu.tr
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09.02. Internal Sciences
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Current Staff
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Sustainable Development Goals
8
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0
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9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
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10
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17
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0
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12
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0
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7
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0
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1
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5
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13
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4
QUALITY EDUCATION
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14
LIFE BELOW WATER
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2
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15
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16
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6
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3
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1
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11
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0
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Documents
68
Citations
438
h-index
12
Documents
68
Citations
388
Scholarly Output
12
Articles
11
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21/10
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0
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0
WoS Citation Count
34
Scopus Citation Count
36
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3
Scopus h-index
3
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0
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0
WoS Citations per Publication
2.83
Scopus Citations per Publication
3.00
Open Access Source
7
Supervised Theses
0
| Journal | Count |
|---|---|
| Postepy W Kardiologii Interwencyjnej | 2 |
| Arquivos brasileiros de cardiologia | 2 |
| Cardiovascular surgery and interventions | 1 |
| Diagnostics | 1 |
| Echocardiography | 1 |
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12 results
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Now showing 1 - 10 of 12
Article Citation - WoS: 1Citation - Scopus: 1Screening Tests Predicting Cancer Metastasis in the Etiology of Pericardial Effusion: Halp Score and Pni(Sociedade Brasileira de Cardiologia, 2024) Koyun, E.; Dindas, F.; Sahin, A.; Cerik, I.B.; Doğduş, MustafaBackground: Cancer screening is absolutely necessary in patients with pericardial effusion, given that cancer is one of the most serious diseases in the etiology of pericardial effusion. In previous studies, it was stated that the systemic immune-inflammation index (SII); the prognostic nutrition index (PNI); and the hemoglobin, albumin, lymphocyte, platelet (HALP) score can produce scores related to cancer. Objectives: This study began considering that these scoring systems could predict cancer in the etiology of patients with pericardial effusion. Methods: This study produced a retrospective analysis of patients who underwent pericardiocentesis between 2006 and 2022. Pericardiocentesis was performed in a total of 283 patients with moderate-to-large pericardial effusion or pericardial tamponade within the specified period. HALP, PNI, and SII scores were calculated according to the peripheral venous blood taken before the pericardiocentesis procedure. The statistical significance level was set at p<0.05. Results: The HALP score proved to be 0.173 (0.125-0.175) in cancer patients and 0.32 (0.20-0.49) in non-cancer patients (p<0.001). The PNI score proved to be 33.1±5.6 in cancer patients and 39.8±4.8 in non-cancer patients (p<0.001). Conclusion: The HALP score and PNI proved to be easy and fast cancer screening tests that can predict cancer metastasis in the etiology of patients with pericardial effusion. © 2024, Sociedade Brasileira de Cardiologia. All rights reserved.Article Citation - WoS: 4Citation - Scopus: 5Demonstration of Subclinical Left Ventricular Electrical and Mechanical Dysfunction in Overweight Subjects by Frontal Qrs-T Angle and 3d-Speckle Tracking Echocardiography(Wiley, 2023) Mammadov, G.; Taşkın, Uğur; Dindaş, Ferhat; Doğduş, MustafaBackgroundOverweightness is a considerable step in the process leading to obesity. There are no sufficient studies on the effect of cardiomyopathy defined in obese patients about overweight subjects. We thought that it may be useful to examine the myocardial involvement in overweight individuals electro-mechanically with more sensitive techniques before the development of obesity cardiomyopathy. AimThe aim of the present study was to demonstrate whether or not there are subclinical left ventricular (LV) electrical and mechanical dysfunctions in overweight patients using frontal QRS-T (fQRS-T) angle (electrically) and 3D-speckle tracking echocardiography (mechanically). MethodsA total of 80 overweight patients and 80 age- and sex-matched normal weight individuals were enrolled into the study. 3D-STE examinations of the patients were performed. Electrocardiographic recordings were obtained for fQRS-T angle assessment. ResultsThe LV-GLS and LV-GCS were significantly depressed in the overweight group than in the normal weight group (-14.5 & PLUSMN; 3.4 vs. -21.7 & PLUSMN; 3.6, p < .001; -15.2 & PLUSMN; 4.6 vs. -24.3 & PLUSMN; 4.8, p < .001, respectively). The fQRS-T angle was found to be increased in the overweight group (142.5 & PLUSMN; 39.2 vs. 114.7 & PLUSMN; 43.5, p = < .001). Statistically significant positive linear correlations were observed between BMI with LV-GLS, LV-GCS, and fQRS-T angle. LV-GLS and LV-GCS were found to be disrupted linearly as BMI increased (r = .718 for BMI and LV-GLS, r = .653 for BMI and LV-GCS). As BMI increased, it was found that the fQRS-T angle increased (r = .692 for BMI and fQRS-T angle). ConclusionOur results support that, overweight individuals, despite their being apparently healthy, may have subclinical LV myocardial mechanical and electrical dysfunction.Article Exploring Hypertension Awareness in Physicians: A Cross-Sectional Study From Turkey(Termedia Publishing House Ltd, 2025) Taskin, Ugur; Fici, Francesco; Altin, Cihan; Dogdus, Mustafa; Mammadov, Ganbar; Topaloglu, Caner; Tengiz, IstemihanIntroduction: Hypertension is a significant public health concern and a contributor to cardiovascular conditions. Although physicians are essential in preventing and managing hypertension, limited research has been conducted on their own awareness of the condition. Aim: We aimed to examine the prevalence and awareness of hypertension among doctors in Turkey and identify relevant demographic and behavioral risk factors. Material and methods: A cross-sectional study was carried out with 178 physicians aged 25 to 64, randomly chosen from 35 healthcare institutions in 24 cities across Turkey. Data collection involved a structured questionnaire that examined hypertension awareness, sociodemographic details, and cardiovascular risk factors, complemented by standardized blood pressure assessments and body measurements. Hypertension was identified based on a systolic blood pressure of >= 140 mm Hg and/or a diastolic pressure of >= 90 mm Hg, self-reported diagnosis, or the use of antihypertensive drugs. Results: The overall prevalence of hypertension was 15.7%, with a significantly higher rate among males (20.2%) than females (7.8%) (p = 0.03). Age was a strong predictor, as individuals over 40 years had a markedly higher hypertension prevalence (27.9%) compared to those under 40 (4.3%) (p < 0.001). Body mass index (BMI), smoking, and physical inactivity were also significantly associated with hypertension. Among hypertensive doctors, awareness was 78.5%, though it did not show significant differences based on gender, BMI, or comorbidities. Conclusions: Despite relatively high awareness levels, hypertension remains prevalent among medical professionals, particularly in older and male doctors. Targeted strategies, such as routine screenings and lifestyle intervention programs, are essential to improve hypertension prevention and management in this population.Article Citation - WoS: 10Citation - Scopus: 10Evaluation of Plasma Atherogenic Index, Triglyceride-Glucose Index and Other Lipid Ratios as Predictive Biomarkers of Coronary Artery Disease in Different Age Groups(MDPI, 2024) Okan, Taha; Doruk, Mehmet; Öztürk, Ali; Topaloğlu, Caner; Doğduş, Mustafa; Yılmaz, Mehmet Birhan(1) Background: Dyslipidaemia and insulin resistance are major risk factors for coronary artery disease (CAD). This study investigated the relationship between plasma atherogenic index (PA-I), triglyceride-glucose index (TGI) and other lipid ratios with the presence and prediction of CAD among different age categories. (2) Methods: The study included 223 participants diagnosed with CAD and those with normal coronary arteries (normal group) by coronary computed tomography angiography (CCTA). Participants were categorised by age and sex: premature CAD (PCAD) for men under 55 and women under 65, and older groups as elderly. (3) Results: PA-I, Lipid Combined Index, Castelli Risk Indices, and TGI were significantly higher in the PCAD group compared to the control group (p < 0.05). ROC analysis showed that a PA-I cut-off of 0.41 had a sensitivity of 62% and a specificity of 58% for predicting PCAD, while a TGI cut-off of 8.74 had a sensitivity of 68% and a specificity of 62%. In the elderly, no significant differences in these indices were found between the CAD and normal groups. (4) Conclusions: Traditional lipid profiles and non-traditional lipid indices such as PA-I and TGI show significant differences in predicting CAD in younger populations but not in older groups. TGI and PA-I may be promising biomarkers for the prediction of PAD, although further validation is needed.Article Citation - WoS: 3Citation - Scopus: 3Evaluation of Left Atrial and Left Ventricular Functions With 3d Speckle-Tracking Echocardiography in Patients With Coronary Artery Tortuosity(John Wiley and Sons Inc, 2023) Taskin, U.; Mammadov, G.; Topaloğlu, Caner; Koyuncu, I.; Doğduş, MustafaBackground: Tortuosity in the coronary arteries is a very common entity encountered during angiography. The effect of coronary artery tortuosity (CAT) on the myocardium has not been completely investigated. The aim of the current study was to assess the effects of CAT on left atrial (LA) and left ventricular (LV) myocardial functions by 3D speckle-tracking echocardiography (3D-STE). Methods: Seventy-five patients with CAT and 80 age- and gender-matched controls who proved to have normal coronary angiograms (CAG) were enrolled into the study. Following CAG, the 2D images were obtained first, and then 3D images were obtained for strain analysis. Results: The LAS-r, LAS-active, and LV-GLS were significantly depressed in the CAT (+) group (p <.001, p <.001, p =.012, respectively). The multivariate regression models demonstrated that LAS-r (p <.001), LAS-active (p =.009), and LV-GLS (p =.024) were found to be independent factors predicting CAT. Conclusion: The current study is the first to focus on the assessing both LA and LV myocardial dynamics in CAT (+) patients by strain echocardiography. The results of our study support the patients with CAT may have subclinical LA and LV myocardial involvements. © 2023 Wiley Periodicals LLC.Article Citation - WoS: 13Citation - Scopus: 14Real-World Data on Empagliflozin and Dapagliflozin Use in Patients With Heart Failure: the Red-Heart Study(Wiley Periodicals, Inc, 2024) Kocabaş, Umut; Ergin, Işıl; Yavuz, Veysel; Altın, Cihan; Kaplan, Mehmet; Oztekin, Guelsuem Meral Yilmaz; Dogdus, MustafaAims: We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting. Methods: Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023. Results: The study population consisted of 1923 patients with HF, predominantly men (61.2%), with a median age of 66 (range: 19-101) years. Overall, 925 patients (48.1%) were receiving SGLT2is. Among the study population, 22.1% had HF with preserved ejection fraction, 21.5% had HF with mildly reduced ejection fraction, 56.4% had HF with reduced ejection fraction and the use of SGLT2is was 42.0%, 47.9% and 50.6% in each group, respectively (P = 0.012). The use of SGLT2is was 76.6% in patients with HF and diabetes, 19.8% in patients with HF and chronic kidney disease and 26.8% in patients without diabetes and chronic kidney disease (P < 0.001). Higher education level [odds ratio (OR): 1.80; 95% confidence interval (CI): 1.06-3.05; P = 0.027], higher household income (OR: 3.46; 95% CI: 1.27-9.42; P = 0.015), New York Heart Association functional class IV (OR: 2.72; 95% CI: 1.16-6.35; P = 0.021), diabetes (OR: 9.42; 95% CI: 6.72-13.20; P < 0.001), the use of angiotensin receptor-neprilysin inhibitors (ARNis) (OR: 4.09; 95% CI: 2.39-7.01; P < 0.001), the use of mineralocorticoid receptor antagonists (MRAs) (OR: 2.02; 95% CI: 1.49-2.75; P < 0.001), the use of loop diuretics (OR: 1.62; 95% CI: 1.18-2.22; P = 0.003) and the use of thiazide diuretics (OR: 1.72; 95% CI: 1.30-2.29; P < 0.001) were independently associated with the use of SGLT2is. Conversely, atrial fibrillation (OR: 0.63; 95% CI: 0.45-0.88; P = 0.008), chronic kidney disease (OR: 0.53; 95% CI: 0.37-0.76; P = 0.001), the use of dihydropyridine calcium channel blockers (OR: 0.68; 95% CI: 0.48-0.98; P = 0.042) and the use of statins (OR: 0.67; 95% CI: 0.49-0.91; P = 0.010) were independently associated with the non-use of SGLT2is. Conclusions: The RED-HEART study provided comprehensive real-world data about implementing SGLT2is in patients with HF. These results suggest that there is a need for organized action and close collaboration between healthcare providers to improve the implementation of SGLT2is, especially in patients with HF with preserved ejection fraction and chronic kidney disease.Article Electromechanical Demonstration of Premature Ventricular Contraction-Induced Atrial Cardiomyopathy by P Wave Duration-to-Amplitude Ratio (PWDAR) and Left Atrial Strain(Termedia Publishing House Ltd, 2025) Dogdus, Mustafa; Okan, Taha; Taskin, Ugur; Mammadov, Ganbar; Akkaya, Bekir; Koyuncu, Ilhan; Topaloglu, CanerIntroduction: High premature ventricular contraction (PVC) burden is known to cause atrial remodeling. P wave duration-to-amplitude ratio (PWDAR) is a new P wave index that includes both P wave duration and P wave voltage, which can be considered to effectively evaluate atrial cardiomyopathy. 3D speckle-tracking echocardiography is accepted as a valid and reliable technique for assessment of the left ventricle (LV) and left atrium (LA). Aim: In the present study, we investigated whether patients with a high PVC burden exhibit subclinical left atrial electrical and mechanical dysfunction, assessed electrically using PWDAR and mechanically using 3D-speckle tracking echocardiography. Material and methods: Seventy-five patients with PVC (PVC+) and 75 age- and gender-matched controls were enrolled in the study. Surface 12-lead standard electrocardiograms (ECGs) were recorded. Clinical characteristics and laboratory values of the patients were obtained. Conventional 2D echocardiographic and 3D-STE analyses were performed. Results: The PWDAR was significantly higher in the PVC+ group than in the control group (p < 0.001); and the LAS-r, LAS-active, and LV-GLS were significantly depressed in the PVC+ group (p < 0.001, p < 0.001, p = 0.015, respectively). The multivariate regression models demonstrated that PWDAR (p < 0.001), LAS-r (p < 0.001), LAS-active (p = 0.008), and LV-GLS (p = 0.021) were independent factors predicting PVC-induced atrial cardiomyopathy (PVC-ACMP). Conclusions: Our results revealed subclinical left atrial electrical and mechanical dysfunction in patients with a high PVC burden. PWDAR and left atrial strain parameters can predict PVC-ACMP.Editorial Investigation of Subclinical Left Ventricular Systolic Dysfunction in Patients With Type 2 Diabetes Mellitus: Is It Beneficial To Evaluate Myocardial Work and Triglyceride-Glucose Index Together?(Wiley, 2024) Doğduş, Mustafa[No abstract available]Article Citation - WoS: 2Citation - Scopus: 2A New Scoring System for the Evaluation of Ibrutinib-Associated Arrhythmias in Chronic Lymphocytic Leukemia: the ACEF Score(Turkish Society of Hematology, 2024) Ugur, Mehmet Can; Bilgir, Oktay; Dogdus, Mustafa; Koyuncu, İlhan; Senoz, Oktay; Koyun, Emin; Koyuncu, BetulAmaç: Kardiyak dokuda Bruton tirozin kinaz inhibisyonu, stres sırasında dokunun korunmasından sorumlu olan PI3K-AKT sinyal yolunun inhibisyonuna neden olur. Bu nedenle aritmi riskinde bir artış vardır. Bu çalışma, yaş, kreatinin ve ejeksiyon fraksiyonu komponentlerini temel alan ve basit bir puanlama sistemi olan Yaş-Kreatinin-Ejeksiyon Fraksiyonu (ACEF) skoru ile bu riskin tahmin edilebilmesini araştırmaktadır. Gereç ve Yöntemler: Kronik lenfositik lösemi (KLL) tanısı alan ve en az 1 yıldır ibrutinib tedavisi alan hastalar ekokardiyografi ve Holter elektrokardiyografi ile değerlendirildi ve sonuçlar tedavi almayan KLL hastalarından oluşan kontrol grubuyla karşılaştırıldı. ACEF skoru, yaş/sol ventriküler ejeksiyon fraksiyonu+1 (kreatinin >2,0 mg/dL ise) formülüyle hesaplandı. Bulgular: Hastaların aritmi gelişimi değerlendirildiğinde paroksismal atriyal fibrilasyon (PAF) dışındaki aritmi türleri açısından kontrol ve ibrutinib grupları arasında istatistiksel olarak anlamlı bir fark bulunmadı. PAF, ibrutinib kullanmayanlar ile kullananlar arasında %8’e karşı %22 (p=0,042) oranında meydana gelmekteydi. İbrutinib kullanan hastalarda ACEF skorunun >1,21 olması, PAF gelişimini %77 duyarlılık ve %75 özgüllükle öngörmekteydi (eğri altındaki alan: 0,830, %95 güven aralığı: 0,698-0,962, p<0,001). Sonuç: ACEF skoru, KLL tanısı alan ve ibrutinib başlanması planlanan hastalarda PAF gelişimini öngören bir risk skoru olarak kullanılabilir.Article Citation - WoS: 1Ablation of Atrioventricular Nodal Reentrant Tachycardia With Focal Cryoablation, Compared With Radiofrequency Ablation: Single-Center Experience(Arquivos Brasileiros Cardiologia, 2024) Topaloğlu, Caner; Fici, Francesco; Van de Borne, Philippe; Taşkın, Uğur; Doğduş, Mustafa; Saygı, Serkan; Tengiz, İstemihanBackground: The ablation of atrioventricular nodal reentrant tachycardia (AVNRT) with cryoablation is an alternative to radiofrequency (RF) ablation in patients due to the low risk of total atrioventricular block. An increase in early-late recurrences after cryoablation is reported as an important disadvantage. Objectives: In this study, we aimed to compare the acute procedural success and the long-term recurrence rates of patients, with AVNRT who underwent methods. Methods: 73 patients with AVNRT were included in the study: 32 with cryoablation and 41 with RF ablation. There was no statistically significant difference between acute procedural success in methods. The ablation procedure was performed by an operator experienced in arrhythmology. The choice of RF or cryoablation was made in the electrophysiology laboratory based on the material already available during the procedure. After the procedure, the patients were evaluated every 3 months for 2 years in polyclinic control. The significance level adopted in the statistical analysis was 5%. Results: The 2 groups of patients were homogeneous. The fluoroscopy time (p<0.001) was shorter, but atrium-his (p=0.004) and his-ventricular (p=0.015) times were longer in the cryoablation group. There was no significant difference, in terms of acute procedural success, post-procedure jump without a single echo, and presence of echo and jump. Conclusions: Cryoablation requires less fluoroscopy time and is a safe non-inferior alternative to RF ablation in patients with AVNRT. The risk of AV block is a significant problem with the use of RF energy, making it less suitable for use in young and physically active patients.
