Impact of Renal Ischemia on Renal Failure After Partial Nephrectomy

Abstract

Partial nephrectomy (PN) became the current gold standard treatment in renal localized T1 cancer following the demonstration of cancer-specific survival rates to be similar with those of radical nephrectomy ( RN). The duration of intra-operative ischemia required to ensure the least negative impact on renal function during intervention is unclear. Optimization of the time of ischemic interval during surgery is one of the manageable parameters in the prevention of renal function loss. There is a strong association between the quality and quantity of renal tissue that is preserved after surgery and long-term renal function. Although available data suggest the benefit of not exceeding 25 minutes for warm ischemia by preservin renal parenchyma as much as possible, cold ischemia safely facilitates longer durations of ischemia. In this review, we aimed to discuss the renal ischemic impact of renal function after PN.