Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/1341
Title: Ag-intercalation of Tm3+/Er3+ Co-doped layered perovskites and their exfoliated 2D nanosheets with an enhanced antibiofilm and antibacterial activity
Authors: Gunay, Bensu
Doger, Hilal
Karagonlar, Zeynep Firtina
Saglam, Ozge
Keywords: Rare-earth doped materials
Layered perovskites
Single oxide nanosheets
Two-dimensional materials
Antibiofilm
Antibacterial
In vitro cytotoxicity
Ruddlesden-Popper Phases
Oxide
Flocculation
K2la2ti3o10
Publisher: Elsevier
Abstract: There is a significant demand for antibiofilm and antimicrobial materials in the medical device industry. It is well established that Ag-based compounds have a high antimicrobial efficiency. Without being in a lattice, silver's antimicrobial action is mainly mediated by the release of Ag+ ions from the compound. These ions at high levels are toxic to most bacterial species. However, rapidly released Ag+ ions tend to aggregate and lose their anti-bacterial effect over time. Thus, utilizing a new approach for using silver as an antimicrobial agent based on imparting the antimicrobial action through contact, rather than releasing Ag+ ions could be beneficial. Here we report that Ag+ ions intercalation of Tm/Er co-doped layered perovskites and their 2D nanosheets exhibit antibacterial and antibiofilm activities against the human opportunistic pathogens Escherichia coli and Bacillus subtilis. Specifically, flocculation of nanosheets with Ag+ ions had efficient antibacterial and antibiofilm activity at 100 mu g/mL. In addition, the flocculated product demonstrated low in vitro cytotoxicity against the Huh7 hepatocellular carcinoma cell line and HEK 293 embryonic kidney cell line. Our results indicate that Ag-intercalated layered perovskites and the flocculation of the nanosheets hold great promise to be used for anti-microbial and antibiofilm purposes in biomedical engineering applications.
URI: https://doi.org/10.1016/j.mtcomm.2022.104972
https://hdl.handle.net/20.500.14365/1341
ISSN: 2352-4928
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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