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https://hdl.handle.net/20.500.14365/2658
Title: | A Preliminary Study of Possible Fibrotic Role of Meprin Metalloproteases in Scleroderma Patients | Authors: | Kocak, Ayse Avsar, Aydan Koken Harmancı, Duygu Akdogan, Gul Birlik, A. Merih |
Keywords: | Activator protein-1 meprin-alpha meprin-beta scleroderma Systemic-Sclerosis Procollagen Proteinases Beta Alpha Cleavage Pathogenesis Classification Mechanisms Cancer |
Publisher: | Turkish League Against Rheumatism | Abstract: | Objectives: This study aims to investigate the possible fibrotic role of meprin metalloproteases and possible fibrotic effects of activator protein-1 (AP-1) in scleroderma patients. Patients and methods: Between April 2018 and April 2019, a total of 85 scleroderma patients (9 males, 76 females; mean age: 54.9 +/- 12.1 years; range, 22 to 80 years) who met the 2013 American College of Rheumatology/European League Against Rheumatism criteria and 80 healthy control individuals (10 males, 70 females; mean age 42.9 +/- 10.2 years; range, 19 to 65 years) were included. Patients' data and blood samples were collected. Messenger ribonucleic acid expressions of interleukin (IL)-6, AP-1 subunits, and tumor necrosis factor-alpha (TNF-alpha) were analyzed by quantitative real-time polymerase chain reaction. Serum meprin alpha and beta protein levels were analyzed using the enzyme-linked immunosorbent assay. Results: Meprin alpha and meprin beta protein levels increased in scleroderma patients. The AP-1 subunits (c-Fos, c-Jun), IL-6, and TNF-alpha increased in scleroderma patients, compared to controls. Conclusion: Our results provide evidence showing that increased meprins levels may be related to AP-1 levels and increased meprins levels may responsible for increased inflammatory TNF-alpha and IL-6 levels. All these data suggest meprins as promising therapeutic targets to restore the balance between inflammation and extracellular matrix deposition in scleroderma. | URI: | https://doi.org/10.46497/ArchRheumatol.2021.8581 https://search.trdizin.gov.tr/yayin/detay/511479 https://hdl.handle.net/20.500.14365/2658 |
ISSN: | 2618-6500 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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