Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14365/5577
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DC Field | Value | Language |
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dc.contributor.author | Santinelli, F.B. | - |
dc.contributor.author | Abasıyanık, Z. | - |
dc.contributor.author | Ramari, C. | - |
dc.contributor.author | Gysemberg, G. | - |
dc.contributor.author | Kos, D. | - |
dc.contributor.author | Pau, M. | - |
dc.contributor.author | Kalron, A. | - |
dc.date.accessioned | 2024-10-25T15:17:56Z | - |
dc.date.available | 2024-10-25T15:17:56Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2211-0348 | - |
dc.identifier.uri | https://doi.org/10.1016/j.msard.2024.105909 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.14365/5577 | - |
dc.description.abstract | Background: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e., gait quality fatigability- GQF) may occur independently or alongside DWF. Objective: i) to investigate how walking fatigability manifests and its prevalence in pwMS; ii) to describe the temporal pattern of the changes of specific gait characteristics during the 6-minute walking test (6MWT) Methods: Eighty-eight pwMS (EDSS 4[0–6.5], 49[21–70] years) and 47 healthy controls (HC- 46[25–60] years) performed the 6MWT wearing inertial measurement units. Gait characteristics (stride length, sensor-based gait speed, cadence, double support, step duration, stance phase, step duration asymmetry, step duration variability, foot-strike, toe-off, and leg circumduction) and walking distance were recorded in 1-minute intervals. A fatigability index was calculated by comparing the last and first minute of the 6MWT to identify abnormal worsening based on cutoff scores. The manifestation of walking fatigability was counted. The temporal pattern of worsening of gait characteristics during the 6MWT was examined in pwMS exceeding the cutoff values, compared to pwMS without abnormal changes and HC, using a two-way ANOVA (group vs. minutes) Results: Thirty-five pwMS presented both DWF and GQF, 2 presented isolated DWF, 27 presented isolated GQF, and 24 presented non-walking fatigability. PwMS having GQF presented worsening in gait characteristics (cadence, step duration, step duration variability, or toe-off angle) from minute 2 onwards of the 6MWT, while HCs and pwMS without abnormal changes stabilized gait from minute 2 towards the end of the 6MWT. Conclusion: Walking fatigability in pwMS manifests not only as a decrease in walking distance but also as changes in gait quality. Understanding changes in gait characteristics during walking can help tailor rehabilitation interventions. © 2024 Elsevier B.V. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Multiple Sclerosis and Related Disorders | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Fatigue | en_US |
dc.subject | Gait analysis | en_US |
dc.subject | Gait quality | en_US |
dc.subject | Multiple sclerosis | en_US |
dc.subject | Walking fatigability | en_US |
dc.subject | adult | en_US |
dc.subject | aged | en_US |
dc.subject | anthropometry | en_US |
dc.subject | Article | en_US |
dc.subject | assessment of humans | en_US |
dc.subject | cardiovascular disease | en_US |
dc.subject | clinical trial (topic) | en_US |
dc.subject | cognition | en_US |
dc.subject | controlled study | en_US |
dc.subject | cross-sectional study | en_US |
dc.subject | Expanded Disability Status Scale | en_US |
dc.subject | fatigue | en_US |
dc.subject | Fatigue Impact Scale | en_US |
dc.subject | female | en_US |
dc.subject | gait | en_US |
dc.subject | human | en_US |
dc.subject | kinematics | en_US |
dc.subject | leg circumduction | en_US |
dc.subject | male | en_US |
dc.subject | Modified Fatigue Scale | en_US |
dc.subject | MS Walking Scale 12 | en_US |
dc.subject | multiple sclerosis | en_US |
dc.subject | Multiple Sclerosis Walking Scale | en_US |
dc.subject | prevalence | en_US |
dc.subject | six minute walk test | en_US |
dc.subject | step time | en_US |
dc.subject | step time variability | en_US |
dc.subject | stride length | en_US |
dc.subject | Symbol Digit Modality Test | en_US |
dc.subject | Timed 25-foot walking | en_US |
dc.subject | walking | en_US |
dc.subject | walking distance | en_US |
dc.subject | walking fatigability | en_US |
dc.subject | walking speed | en_US |
dc.title | Manifestations of walking fatigability in people with multiple sclerosis based on gait quality and distance walked during the six minutes walking test | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.msard.2024.105909 | - |
dc.identifier.scopus | 2-s2.0-85205429582 | en_US |
dc.department | İzmir Ekonomi Üniversitesi | en_US |
dc.authorscopusid | 57203973419 | - |
dc.authorscopusid | 57215387328 | - |
dc.authorscopusid | 57200521423 | - |
dc.authorscopusid | 59281419600 | - |
dc.authorscopusid | 6603196344 | - |
dc.authorscopusid | 7005060268 | - |
dc.authorscopusid | 24504227700 | - |
dc.identifier.volume | 91 | en_US |
dc.institutionauthor | … | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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