Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5577
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dc.contributor.authorSantinelli, F.B.-
dc.contributor.authorAbasıyanık, Z.-
dc.contributor.authorRamari, C.-
dc.contributor.authorGysemberg, G.-
dc.contributor.authorKos, D.-
dc.contributor.authorPau, M.-
dc.contributor.authorKalron, A.-
dc.date.accessioned2024-10-25T15:17:56Z-
dc.date.available2024-10-25T15:17:56Z-
dc.date.issued2024-
dc.identifier.issn2211-0348-
dc.identifier.urihttps://doi.org/10.1016/j.msard.2024.105909-
dc.identifier.urihttps://hdl.handle.net/20.500.14365/5577-
dc.description.abstractBackground: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e., gait quality fatigability- GQF) may occur independently or alongside DWF. Objective: i) to investigate how walking fatigability manifests and its prevalence in pwMS; ii) to describe the temporal pattern of the changes of specific gait characteristics during the 6-minute walking test (6MWT) Methods: Eighty-eight pwMS (EDSS 4[0–6.5], 49[21–70] years) and 47 healthy controls (HC- 46[25–60] years) performed the 6MWT wearing inertial measurement units. Gait characteristics (stride length, sensor-based gait speed, cadence, double support, step duration, stance phase, step duration asymmetry, step duration variability, foot-strike, toe-off, and leg circumduction) and walking distance were recorded in 1-minute intervals. A fatigability index was calculated by comparing the last and first minute of the 6MWT to identify abnormal worsening based on cutoff scores. The manifestation of walking fatigability was counted. The temporal pattern of worsening of gait characteristics during the 6MWT was examined in pwMS exceeding the cutoff values, compared to pwMS without abnormal changes and HC, using a two-way ANOVA (group vs. minutes) Results: Thirty-five pwMS presented both DWF and GQF, 2 presented isolated DWF, 27 presented isolated GQF, and 24 presented non-walking fatigability. PwMS having GQF presented worsening in gait characteristics (cadence, step duration, step duration variability, or toe-off angle) from minute 2 onwards of the 6MWT, while HCs and pwMS without abnormal changes stabilized gait from minute 2 towards the end of the 6MWT. Conclusion: Walking fatigability in pwMS manifests not only as a decrease in walking distance but also as changes in gait quality. Understanding changes in gait characteristics during walking can help tailor rehabilitation interventions. © 2024 Elsevier B.V.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofMultiple Sclerosis and Related Disordersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFatigueen_US
dc.subjectGait analysisen_US
dc.subjectGait qualityen_US
dc.subjectMultiple sclerosisen_US
dc.subjectWalking fatigabilityen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectanthropometryen_US
dc.subjectArticleen_US
dc.subjectassessment of humansen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectclinical trial (topic)en_US
dc.subjectcognitionen_US
dc.subjectcontrolled studyen_US
dc.subjectcross-sectional studyen_US
dc.subjectExpanded Disability Status Scaleen_US
dc.subjectfatigueen_US
dc.subjectFatigue Impact Scaleen_US
dc.subjectfemaleen_US
dc.subjectgaiten_US
dc.subjecthumanen_US
dc.subjectkinematicsen_US
dc.subjectleg circumductionen_US
dc.subjectmaleen_US
dc.subjectModified Fatigue Scaleen_US
dc.subjectMS Walking Scale 12en_US
dc.subjectmultiple sclerosisen_US
dc.subjectMultiple Sclerosis Walking Scaleen_US
dc.subjectprevalenceen_US
dc.subjectsix minute walk testen_US
dc.subjectstep timeen_US
dc.subjectstep time variabilityen_US
dc.subjectstride lengthen_US
dc.subjectSymbol Digit Modality Testen_US
dc.subjectTimed 25-foot walkingen_US
dc.subjectwalkingen_US
dc.subjectwalking distanceen_US
dc.subjectwalking fatigabilityen_US
dc.subjectwalking speeden_US
dc.titleManifestations of walking fatigability in people with multiple sclerosis based on gait quality and distance walked during the six minutes walking testen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.msard.2024.105909-
dc.identifier.scopus2-s2.0-85205429582en_US
dc.departmentİzmir Ekonomi Üniversitesien_US
dc.authorscopusid57203973419-
dc.authorscopusid57215387328-
dc.authorscopusid57200521423-
dc.authorscopusid59281419600-
dc.authorscopusid6603196344-
dc.authorscopusid7005060268-
dc.authorscopusid24504227700-
dc.identifier.volume91en_US
dc.identifier.wosWOS:001331509100001en_US
dc.institutionauthor-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.grantfulltextnone-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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