Assessment of ophthalmic vascular changes in fibromyalgia patients using optical coherence tomography angiography: is there a real pathology?

Abstract

Background: Fibromyalgia (FM) is a widespread musculoskeletal pain disorder. Although the pathogenesis of fibromyalgia is unknown, central neurotransmitter systems and autonomic nervous system abnormalities may play a critical role. Today, the diagnosis is made by clinical findings, and there is no objective, confirmatory tests. Studies examining ophthalmic structures in patients with fibromyalgia using optic coherence tomography (OCT) and optic coherence tomography angiography (OCTA) sought objective evidence of both the neurodegenerative and vascular processes of the disease. In the results of these few studies, some findings of retinal and vascular density changes were found. Materials and methods: In this cross-sectional study, retinal superficial and deep vascular plexus density (SVP and DVP), choroid thickness, and choriocapillaris density were investigated in 42 patients with fibromyalgia and 42 healthy controls using OCTA. Results: 42 fibromyalgia patients, including 42 age- and gender-matched healthy controls, were enrolled in this study. Central macular thickness (CMT) was found to be significantly thinner in fibromyalgia patients than in healthy groups. Retinal SVP and DVP were evaluated. No significant differences were observed between FM patients and control subjects as regards DVP density in the macular area. However, SVP density significantly decreased in the superior and inferior quadrants of fibromyalgia patients compared to the healthy controls. There was no significant difference in choriocapillaris density and choroid thickness between the patients with fibromyalgia and the healthy group in all quadrants. Conclusion: We evaluated detailed ophthalmic vascular structures of patients with fibromyalgia using OCTA in our study. We found changes only superior and inferior quadrants of retinal superficial structures. There was no significant difference in other superficial vascular quadrants of the retina, deep vascular structures, and choriocapillaris density. On the other hand, the central macular thickness was thinner in FM patients. Therefore, these data show that the role of vascular processes in the pathogenesis of fibromyalgia is small, but thinner central macular thickness in FM may be significant as an objective finding of the disease © 2023 The Authors