Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/940
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dc.contributor.authorInce, Iskender-
dc.contributor.authorYildirim, Yeliz-
dc.contributor.authorGuler, Gunnur-
dc.contributor.authorMedine, Emin Ilker-
dc.contributor.authorBallica, Gulsah-
dc.contributor.authorKusdemir, Bekir Cem-
dc.contributor.authorGoker, Erdem-
dc.date.accessioned2023-06-16T12:48:02Z-
dc.date.available2023-06-16T12:48:02Z-
dc.date.issued2020-
dc.identifier.issn0236-5731-
dc.identifier.issn1588-2780-
dc.identifier.urihttps://doi.org/10.1007/s10967-020-07058-z-
dc.identifier.urihttps://hdl.handle.net/20.500.14365/940-
dc.description.abstractThe aim of the present research was to formulate and characterize radioiodinated folic acid-chitosan conjugated thymoquinone nanoparticles (FATQCSNPs) and to increase targeting ability on ovarian cancer cell. The dose of drug-loading into the FATQCSNPs and the amount of folic acid on the FATQCSNPs surface were determined as a 20.0 +/- 1% and 46.0 +/- 0.5%, respectively. Cell viabilities (%) determined on SKOV-3 and Caco-2 cells for 48 h. TQ, TQCS and FATQCS were very cytotoxic with lower IC50 values on both cell lines. At specific-activity-dependent incorporation study, the incorporation efficiencies of I-131-FATQCSNPs was higher than that of I-131-TQ on SKOV3 cell lines.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radıoanalytıcal And Nuclear Chemıstryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinone (TQ)en_US
dc.subjectChitosan nanoparticlesen_US
dc.subjectFolate-receptor-targeteden_US
dc.subjectOvarian canceren_US
dc.subjectInfrared-Spectroscopyen_US
dc.subjectFtir Spectroscopyen_US
dc.subjectFolate Receptorsen_US
dc.subjectDrug-Deliveryen_US
dc.subjectApoptosisen_US
dc.subjectInhibitionen_US
dc.subjectProteinen_US
dc.subjectAgenten_US
dc.titleSynthesis and characterization of folic acid-chitosan nanoparticles loaded with thymoquinone to target ovarian cancer cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s10967-020-07058-z-
dc.identifier.scopus2-s2.0-85080987560en_US
dc.departmentİzmir Ekonomi Üniversitesien_US
dc.authoridYILDIRIM, Yeliz/0000-0002-3014-4510-
dc.authoridKusdemir, Bekir Cem/0000-0001-8905-5769-
dc.authoridmedine, emin ilker/0000-0003-0139-7110-
dc.authorwosidYILDIRIM, Yeliz/AAG-5559-2019-
dc.authorwosidMedine, Emin İlker/GLS-0483-2022-
dc.authorwosidGüler, Günnur/GLQ-7527-2022-
dc.authorwosidyildirim, yeliz/AAT-9491-2021-
dc.authorwosidGüler, Günnur/AAH-6852-2021-
dc.authorwosidKusdemir, Bekir Cem/ABG-6109-2021-
dc.authorscopusid6507731451-
dc.authorscopusid7003747438-
dc.authorscopusid37010966300-
dc.authorscopusid10739428000-
dc.authorscopusid57215504786-
dc.authorscopusid57215493815-
dc.authorscopusid26662691100-
dc.identifier.volume324en_US
dc.identifier.issue1en_US
dc.identifier.startpage71en_US
dc.identifier.endpage85en_US
dc.identifier.wosWOS:000521842900007en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.grantfulltextreserved-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.dept05.02. Biomedical Engineering-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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