Browsing by Author "Özdoğar, Asiye Tuba"

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    Citation - WoS: 2
    Citation - Scopus: 1
    Comparative Analysis of Cognitive and Physical Characteristics in Late-Onset, Adult-Onset and Early-Onset Multiple Sclerosis Patients
    (ELSEVIER SCI LTD, 2024) Özakbaş, Serkan; Kaya, Ergi; Aslan, Taha; Özdoğar, Asiye Tuba; Baba, Cavid
    Background: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients. Methods: The study was conducted as a secondary analysis of a prospective study. The participants were divided into three groups according to age of MS onset: early onset (<18 years of age), adult-onset (20-40 years of age), and late-onset (>55 years of age). Demographic variables, oligoclonal bands, IgG index, and Expanded Disability Status Scale (EDSS) score in admission, first year, second year and current EDSS were evaluated. The Timed 25- Foot Walk Test (T25FW), Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12, Single Leg Standing Test, Activity-Specific Balance Confidence Scale, Nine-Hole Peg Test, Epworth Sleepiness Scale and Restless Legs Syndrome Severity Scale were performed. Appropriate statistical analysis was made. Results: A total of 658 pwMS was included in the study and divided into three groups: EOMS (n n = 117), AOMS (n n = 499), and LOMS (n n = 42). Statistically significant differences were determined between groups in terms of age [L (mean:59.86+5.45 +5.45 years-y-)> A (36.87+9.12 +9.12 y)> E (26.56 +8.85 y), p < 0.001], education level, current EDSS score (L L > E, p < 0.001), EDSS score in first admission, EDSS score in the first year, EDSS score in the second year (L L > A > E, p < 0.001), reached an EDSS score 6 (E E > L p = 0.001, E > A p = 0.015), disease duration (E E > A, E > L , mean E = 11.66+9.7 +9.7 y, A = 7.99+7.4 +7.4 y, L = 6.31+4.67 +4.67 y) time switching second-line treatment to the third line (E E > L p < 0.001, A > L p = 0.002, mean E = 171.73+83.29 +83.29 months-m-, A = 136.13+65.75 +65.75 m, L = 65.85 +45.96 m), number of relapses (A A > E > L , median E = 4.0, A = 3.0, L = 2.0), distribution of MS type and oligoclonal band types. Significant differences were found in T25FW and TUG. Post-hoc analysis showed that participants in the LOMS group have longer T25FW (mean L = 7.8 + 6.11, A = 6.25+5.09, +5.09, E = 5.72+3.13, +3.13, p = 0.011) and TUG (mean L = 11.01+5.53, +5.53, A = 9.57+8.04, +8.04, E = 8.38+5.51, +5.51, p = 0.007) times than the AOMS and EOMS groups. Conclusion: Our result revealed that individuals with LOMS face elevated disability levels and a heightened propensity to transition from first-line treatments to more advanced therapeutic interventions. LOMS have worse lower extremity functional status than AOMS and EOMS patient. Clinical evaluations and treatment choices require more attention in LOMS. However, according to the low number of LOMS in our cohort, these results were considered cautious, and more wide and multi-center studies must be designed.
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    Investigating the Relationship of Theory of Mind and Empathy With Neuroimaging, Neuropsychological, and Neuropsychiatric Data in Persons With Multiple Sclerosis
    (Routledge journals, taylor & francis ltd, 2024) Aslan, Taha; Özdoğar, Asiye Tuba; Sağıcı, Özge; Yiğit, Pınar; Zorlu, Nabi; Bora, Emre; Özakbaş, Serkan
    Theory of Mind (ToM) is understanding others' minds. Empathy is an insight into emotions and feelings of others. Persons with multiple sclerosis (pwMS) may experience impairment in ToM and empathy. To investigate ToM, empathy, and their relationship with neuroimaging, neuropsychological, and neuropsychiatric data. 41 pwMS and 41 HC were assessed using RMET for ToM, EQ, BICAMS, HADS. Cortical and subcortical gray matter volumes were calculated with Freesurfer from 3T MRI scans. pwMS showed lower EQ scores (44.82 +/- 11.9 vs 51.29 +/- 9.18, p = 0.02) and worse RMET performance (22.37 +/- 4.09 vs 24,47 +/- 2.93, p = 0.011). Anxiety and depression were higher in pwMS. EQ correlated with subcortical (amygdala) and cortical (anterior cingulate) volumes. RMET correlated with cortical volumes (posterior cingulate, lingual). In regression analysis, amygdala volume was the single predictor of empathy performance (p = 0.041). There were no significant correlations between social cognitive tests and general cognition. A weak negative correlation was found between EQ and the level of anxiety (r = -0.342, p = 0.038) The present study indicates that pwMS have impairment on ToM and empathy. The performance of ToM and empathy in MS is linked to the volumes of critical brain areas involved in social cognition.
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    Yeni Teşhis Konulan Multipl Sklerozlu Bireylerde Servikal Omurilik Lezyonunun Üst Ekstremite Fonksiyonu Üzerindeki Etkisinin Değerlendirilmesi
    (2025) Cinar, Bilge Piri; Ozakbas, Serkan; Kaya, Ergi; Baba, Cavid; Özdoğar, Asiye Tuba; Yapıcı, Nurbanu Aygündüz; Karakas, Hilal
    Amaç: Çok erken evre multipl skleroz (MS) hastalarında servikal kord lezyonlarının üst ekstremite fonksiyonları üzerindeki etkisini değerlendirmek ve bu popülasyonda üst ekstremite fonksiyonlarını etkileyen faktörleri tanımlamak. Gereç ve Yöntem: Çalışmaya 245 ilk semptomlardan 24 ay geçmiş ve 378 tanıdan sonraki altı ay içinde hastalık modifiye edici tedaviye (DMT) başlamış MS’li bireyler dahil edilmiştir. Üst ekstremite fonksiyonlarını değerlendirmek için Dokuz Çivi Peg Testi (N-HPT) uygulanmıştır. Servikal kord lezyonunun varlığına göre katılımcılar iki gruba ayrıldı. Bulgular: Gruplar arasında yaş, cinsiyet, hastalık süresi ve atak sayısı açısından anlamlı bir fark bulunmamıştır. Ancak, toplam Genişletilmiş Engellilik Durumu Ölçeği (EDSS) skoru, piramidal ve duyusal fonksiyonel sistem skorları, servikal kord lezyonları olan MS’li bireylerde olmayanlara göre daha yüksek bulunmuştur. Tanıdan sonraki altı ay içinde DMT başlatılan katılımcılarda, dominant ve ortalama N-HPT performans süreleri, servikal kord lezyonu olan MS’li bireylerde olmayanlara göre anlamlı derecede daha uzun bulunmuştur. Ancak, ilk semptomlardan 24 ay sonra tanı konulan katılımcılar arasında gruplar arasında anlamlı bir fark gözlenmemiştir. Yaş, hastalık süresi ve tanıdan tedaviye kadar geçen süre, N-HPT performansını etkileyen önemli faktörler olarak belirlenmiştir. Daha genç, daha kısa hastalık süresine sahip ve tanı sonrası daha erken tedavi alan MS’li bireyler, diğerlerine göre daha iyi performans göstermiştir. Sonuç: Çalışmamız, MS’in erken evrelerinde bile servikal kord lezyonlarının üst ekstremite fonksiyonları üzerindeki etkisini vurgulamakta ve erken tanı ile DMT’lerin hızlı bir şekilde başlatılmasının önemini ortaya koymaktadır.