Browsing by Author "Öztura, İbrahim"

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The Evaluation of P300 Component Differences Across Sensory Modalities in Healthy Individuals Aged 50 and Over: Auditory and Visual
(Elsevier, 2021) Kiyi, Ilayda; Öztura, İbrahim; Yener, Görsev
[Abstract Not Available]
Citation - WoS: 7
Citation - Scopus: 8
Normalized Theta but Increased Gamma Activity After Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary Qeeg Study
(Sage Publications Inc, 2023) Fide, Ezgi; Yerlikaya, Deniz; Öz, Didem; Öztura, İbrahim; Yener, Görsev
Acetylcholinesterase inhibitors (AChE-I) are the core treatment of mild to severe Alzheimer's disease (AD). However, the efficacy of AChE-I treatment on electroencephalography (EEG) and cognition remains unclear. We aimed to investigate the EEG power and coherence changes, in addition to neuropsychological performance, following a one-year treatment. Nine de-novo AD patients and demographically-matched healthy controls (HC) were included. After baseline assessments, all AD participants started cholinergic therapy. We found that baseline and follow-up gamma power analyzes were similar between groups. Yet, within the AD group after AChE-I intake, individuals with AD displayed higher gamma power compared to their baselines (P < .039). Also, baseline gamma coherence analysis showed lower values in the AD than in HC (P < .048), while these differences disappeared with increased gamma values of AD patients at the follow-up. Within the AD group after AChE-I intake, individuals with AD displayed higher theta and alpha coherence compared to their baselines (all, P < .039). These increased results within the AD group may result from a subclinical epileptiform activity. Even though AChE-I is associated with lower mortality, our results showed a significant effect on EEG power yet can increase the subclinical epileptiform activity. It is essential to be conscious of the seizure risk that treatment may cause.
Citation - WoS: 10
Citation - Scopus: 11
The Reliability of P300 and the Influence of Age, Gender and Education Variables in a 50 Years and Older Normative Sample
(Elsevier, 2022) Yerlikaya, Deniz; Hunerli-Günduz, Duygu; Fide, Ezgi; Özbek, Yağmur; Kıyı, İlayda; Öztura, İbrahim; Yener, Görsev
Objectives: The present study aims to investigate the effects of age, gender, and level of education on P300 in a healthy population, aged 50 years and over; and determine the reliability metrics for different conditions and measurement methods.Method: Auditory and visual oddball recordings of 171 healthy adults were investigated. A fully automated preprocessing was applied to elicit ERP P300. Maximum peak amplitude, latency and mean amplitudes were measured. Data were stratified by age, gender, and education to determine group-level differences by using repeat measures of ANOVA. The internal consistency of P300 was calculated by a split-half method using odd-even segments. Test-retest reliability was assessed by calculating the intraclass correlation coefficient (ICC).Results: Maximum peak P300 amplitudes were higher in the 50-64 years age group compared to the >65 years age group; and females showed increased P300 amplitudes compared to males. P300 measures showed fair to good internal consistency and poor to good test-retest reliability.Conclusion: Age and gender should be taken into account when designing ERP studies with elderly individuals. P300 showed good internal consistency in general, between gender groups and age groups. Long-term test-retest reliability was lower but acceptable. These findings can be interpreted as the strength of P300 by being an objective and reliable method independent of cultural differences. Here we underline several factors that may affect P300 measures and discuss other possible factors that should be standardized for P300 to be used in clinical settings.