Browsing by Author "Akan, Pinar"

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Citation - WoS: 9
Citation - Scopus: 12
Brain-Derived Neurotrophic Factor in Bipolar Disorder: Associations With Age at Onset and Illness Duration
(Pergamon-Elsevier Science Ltd, 2021) Baykara, Burak; Koc, Dogukan; Resmi, Halil; Akan, Pinar; Tunca, Zeliha; Ozerdem, Aysegul; Ceylan, Deniz
Bipolar disorder (BD) is a heterogeneous disorder that contains neurodevelopmental differences. Defining homogeneous subgroups of BD patients by using age at onset (AAO) as a specifier may promote the classification of biomarkers. This study compares peripheral BDNF levels between pediatric and adult BD patients to investigate the associations between BDNF levels, AAO, and illness duration. We enrolled two groups of euthymic patients, those with pediatric BD (n = 39) and those with adult BD (n = 31), as well as a group of healthy controls (HCs) (n = 90). Participants were assessed using clinical measures and BDNF serum levels were obtained using ELISA. We observed that BDNF levels were comparable between adult BD and HCs, but were clearly lower in pediatric BD than in HCs. In adult BD with AAO ?30 years, BDNF levels were significantly higher than in adult BD with AAO <30 years. In pediatric BD, patients with prepubertal-onset had higher BDNF levels than those with pubertalonset. BDNF levels demonstrated the accuracy of being able to distinguish pediatric BD from healthy controls in a receiver operating characteristic (ROC) curve analysis (area under the curve [AUC] = 0.792). In adult BD, higher BDNF levels were associated with later disease onset, but this was not the case in pediatric BD. Finally, reduced BDNF levels were associated with illness duration in adult BD. The findings indicate that BDNF levels in BD patients are associated with AAO. BDNF may, therefore, potentially serve as a developmental marker in BD, when AAO is taken into account.
Citation - WoS: 5
Citation - Scopus: 8
Increased Plasma Levels of 8-Oxoguanine Dna Glycosylase-1 in Bipolar Disorder
(Wiley, 2019) Ceylan, Deniz; Yilmaz, Selda; Bora, Ugur; Tuna, Gamze; Ildiz, Aysegul; Akan, Pinar; Veldic, Marin
[Abstract Not Available]
Citation - WoS: 1
Increased Serum Levels of Nmda Receptor Antibodies in Female Patients With Bipolar Disorder
(Klinik Psikiyatri Dergisi, 2019) Ceylan, Deniz; Akan, Pinar; Doyuran, Kerim; Can, Gunes; Ersen, Ayca; Misir, Emre; Ozerdem, Aysegul
Objective: Glutamatergic/GABAergic imbalance due to autoimmune antibodies targeting N-methyl-D-aspartate receptors (NMDA-R) is considered to be one of the shared pathways between bipolar disorder (BD) and autoimmune diseases. Evidence shows female vulnerability to autoimmune disorders, and suggests a sex-specific approach in autoimmunity research in BD. We aimed to assess serum concentrations of NMDA-R antibodies and density of NMDA and GABA receptors on platelets in euthymic patients with BD in comparison to healthy individuals; and to determine the impact of sex on serum concentrations of NMDA-R antibodies and the density of NMDA and GABA receptors on platelets. Method: NMDA antibody IgG were detected in serum samples of 27 DSM IV euthymic patients with bipolar disorder (16 females, 11 males) and 33 healthy individuals (17 females, 16 males), using ELISA method. The densities of NMDA and GABA receptors on platelets were investigated using immunocytochemical methods. Results: Patients with BD presented higher serum levels of NMDA-R antibodies in comparison to healthy individuals (p < 0.001). The densities of NMDA and GABA receptor on platelets were similar in both groups. The NMDA-R antibody levels were influenced by both diagnosis and sex (F = 5.813, df = 1, p = 0.020). Tserum lithium levels showed a significant linear association with the serum NMDA-R antibody levels even adjusting for age, sex, body mass index (F = -56.26, t = -2.52, p = 0.015, CI: -101.12/-11.40). Discussion: Our findings support a potential role of NMDA-R antibodies in the underlying pathophysiology of BD, particularly for females.