Browsing by Author "Alptekin, Köksal"

Now showing 1 - 3 of 3

Citation - WoS: 2
Citation - Scopus: 3
Early and Late Contingent Negative Variation (cnv) Reflect Different Aspects of Deficits in Schizophrenia
(Wiley, 2024) Akgül, Özge; Fide, Ezgi; Özel, Fatih; Alptekin, Köksal; Bora, Emre; Akdede, Berna Binnur; Yener, Görsev
Abnormal reward processing and psychomotor slowing are well-known in schizophrenia (SZ). As a slow frontocentral potential, contingent negative variation (CNV) is associated with anticipatory attention, motivation and motor planning. The present study aims to evaluate the early and late amplitude and latencies of CNV in patients with SZ compared to healthy controls during a reward processing task and to show its association with clinical symptoms. We recruited 21 patients with SZ and 22 healthy controls to compare early and late CNV amplitude and latency values during a Monetary Incentive Delay (MID) Task between groups. Patients' symptom severity, levels of negative symptoms and depressive symptoms were assessed. Clinical features of the patients were further examined for their relation with CNV components. In conclusion, we found decreased early CNV amplitudes in SZ during the reward condition. They also displayed diminished and shortened late CNV responses for incentive cues, specifically at the central location. Furthermore, early CNV amplitudes exhibited a significant correlation with positive symptoms. Both CNV latencies were linked with medication dosage and the behavioural outcomes of the MID task. We revealed that early and late CNV exhibit different functions in neurophysiology and correspond to various facets of the deficits observed in patients. Our findings also emphasized that slow cortical potentials are indicative of deficient motivational processes as well as impaired reaction preparation in SZ. To gain a deeper understanding of the cognitive and motor impairments associated with psychosis, future studies must compare the effects of CNV in the early and late phases. The aim was to evaluate the early and late amplitude and latencies of CNV in schizophrenia (SZ) patients compared to healthy controls (HC) during a reward processing task. Decreased early CNV amplitudes in SZ during the reward condition, and diminished and shortened late CNV responses for incentive cues were found. Early CNV amplitudes exhibited a significant correlation with positive symptoms. Both CNV latencies were linked with medication dosage and the behavioural outcomes of the MID task. image
Citation - Scopus: 1
A Real Environment Based Virtual Reality Psychosocial Treatment May Help Patients With Schizophrenia To Increase Social Functioning: A Preliminary Study
(Turkish Association of Nervous and Mental Health, 2023) Hoşgelen, E.I.; Kartelli, F.; Berger, M.; Erinç, S.; Yerlikaya, D.; Özbek, Y.; Yener, Görsev; Alptekin, Köksal
Objective: VR (Virtual Reality) is a novel treatment method for mental disorders. The aim of the study is to investigate the impact of the VR Psychosocial Treatment Program (PTP) on psychosocial functioning and symptoms in people with schizophrenia. Method: Seven schizophrenia patients who have been admitted to the Schizophrenia Outpatient Unit of Dokuz Eylül University School of Medicine and met the diagnosis of schizophrenia according to DSM-V diagnostic criteria were included in the study. Psychosocial functionality level was assessed by PSP (Personal and Social Performance Scale), positive and negative symptom severity with PANSS (Positive and Negative Syndrome Scale), and social skills with SSC (Social Skills Checklist). VR-PTP was continued for a total of 10 sessions and twice a week for five weeks. In this study, a real-environment-based VR-PTP for schizophrenia patients was developed. In the sessions, there were different real-environment-based VR contents including social interaction components such as cafe, market, bazaar, public transportation. Results: There was a statistically significant difference between the PSP scores before and after the VR application (p=0.018). None of the patients reported motion sickness during VR sessions due to the immersive nature of VR. There was no significant difference in PANSS total and subscale scores before and after VR-PTP. Conclusion: In this preliminary study, we discovered that real-environment-based VR-PTP is effective for improving the social skills of patients with schizophrenia. Cognitive enhancement programs and psychosocial functionality therapies may be carried out using virtual reality in the near future. VR can assist patients in coping with their symptoms and day-to-day challenges. © (2023), (Turkish Association of Nervous and Mental Health). All Rights Reserved.
Citation - WoS: 1
Reduced Reward Processing in Schizophrenia: a Comprehensive Eeg Event-Related Oscillation Study
(Springer, 2023) Akgül, Özge; Fide, Ezgi; Özel, Fatih; Alptekin, Köksal; Bora, Emre; Akdede, Berna Binnur; Yener, Görsev
It is well known that abnormal reward processing is a characteristic feature of various psychopathologies including schizophrenia (SZ). Reduced reward anticipation has been suggested as a core symptom of SZ. The present study aims to evaluate the event-related oscillations (EROs) delta, theta, alpha, beta, and gamma in patients with SZ during the Monetary Incentive Delay (MID) task, which elicits the neural activity of reward processing. Twenty-one patients with SZ and twenty-two demographically matched healthy controls were included in the study. EROs were compared between groups and correlation analyses were conducted to determine a possible relationship between clinical scores and ERO values. Compared with healthy controls, the SZ group had reduced (1) delta and theta amplitudes in the reward condition (2) total beta and non-incentive cue-related beta amplitudes, and (3) incentive cue-related frontal gamma amplitudes. These reductions can be interpreted as impaired dopaminergic neurotransmission and disrupted cognitive functioning in the reward processing of SZ. In contrast, SZ patients showed higher incentive cue-related theta and occipital gamma amplitudes compared to controls. These increments may reflect negative symptoms in SZ. Moreover, theta amplitudes showed a negative correlation with Calgary Depression Scale for Schizophrenia scores and a positive correlation with attentional impulsivity. This is the first study showing the impairments of SZ patients in EROs from delta to gamma frequency bands compared with healthy controls during reward anticipation. Being the first comprehensive study, our results can be interpreted as providing evidence for disrupted brain dynamics in the reward processing of SZ studied by EROs. It may become possible to help patients' wellness by improving our understanding of reward processing in schizophrenia and developing innovative rehabilitation treatments based on these findings.