Browsing by Author "Alptekin, Koksal"

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Citation - WoS: 1
Citation - Scopus: 1
Enhanced Punishment Responses in Patients With Schizophrenia: an Event-Related Potential Study
(Sage Publications Inc, 2023) Akgül, Özge; Fide, Ezgi; Özel, Fatih; Alptekin, Koksal; Bora, Emre; Akdede, Berna Binnur; Yener, Gorsev
It is well known that abnormal reward processing is a characteristic feature of various psychopathologies including schizophrenia. Reduced reward anticipation has been suggested as a core symptom of schizophrenia. The Monetary Incentive Delay Task (MID) is frequently used to detect reward anticipation. The present study aims to evaluate the amplitude and latency of event-related potential (ERP) P300 in patients with schizophrenia (SCH) compared to healthy controls during the MID task. Twenty patients with SCH and 21 demographically matched healthy controls (HC) were included in the study. ERP P300 amplitude and latency values were compared between groups using an MID task in which reward and loss cues were presented. Relations between P300 and clinical facets were investigated in the patient group. SCH group had enhanced mean P300 amplitudes and delayed peak latency in the punishment condition compared with HC. These higher responses were also associated with negative symptoms. SCH group showed altered reward processing as being more sensitive to loss of reward conditions as firstly evidenced by electrophysiological methods, possibly due to abnormality in various systems including social withdrawal, social defeat, and behavioral inhibition system.
Citation - WoS: 18
Citation - Scopus: 20
Neurocognitive Functioning During Symptomatic States and Remission in Bipolar Disorder and Schizophrenia: a Comparative Study
(Elsevier Ireland Ltd, 2020) Ceylan, Deniz; Akdede, Berna Binnur; Bora, Emre; Aktener, Ahmet Yigit; Ongun, Ceren Hidiroglu; Tunca, Zeliha; Alptekin, Koksal; Özerdem, Ayşegül; Hıdıroğlu Ongun, Ceren
Aims Patients with bipolar disorder present milder cognitive impairment in comparison to patients with schizophrenia. Psychotic symptoms are associated with poorer cognitive functioning in both disorders. We aim to compare cognitive dysfunction between bipolar disorder and schizophrenia across symptomatic and remitted states. Methods An extensive cognitive battery was used to assess bipolar disorder patients (32 in manic episodes with psychotic features, 44 in euthymia), patients with schizophrenia (41 symptomatic, 39 remitted), and 55 healthy controls. A global cognitive factor and six neurocognitive domain factors were identified using principal component analyses. Results Global cognition components differed according to both illness and remission status; working memory differed according to remission status regardless of diagnosis; verbal fluency differed according to diagnosis regardless of remission status. An omnibus F test revealed that the remission state had a significant impact on processing speed in schizophrenia. Conclusion Our data suggest that both disorders are associated with state dependent (i.e., global cognition and working memory) and diagnosis dependent (i.e., global cognition and verbal fluency) neurocognitive dysfunctions. Processing speed was exclusively influenced by symptomatic states of schizophrenia.
Neurocognitive Functioning in Schizophrenia and Bipolar Disorder During the Remission and the Psychotic States
(Oxford Univ Press, 2018) Ceylan, Deniz; Akdede, Berna Binnur; Bora, Emre; Hidiroglu, Ceren; Tunca, Zeliha; Alptekin, Koksal; Ozerdem, Aysegul
[Abstract Not Available]
Citation - WoS: 3
Citation - Scopus: 4
Virtual Reality Interventions and Psychosocial Functioning in Schizophrenia Spectrum Disorders: a Systematic Review
(Wiley, 2024) Hosgelen, Emine Ilgin; Guneri, Sinem; Erdeniz, Burak; Alptekin, Koksal
ObjectiveThe objective of this study is to evaluate the effectiveness of virtual reality (VR) intervention programs that aim to improve psychosocial functioning in schizophrenia spectrum disorders and evaluate the quality assessment of these studies.MethodsPRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guideline was followed to conduct this systematic review. The literature search was performed in Web of Science (WoS) and PubMed, by two independent researchers on two occasions, on 1 March 2023 and 20 August 2023. Risk of bias of the studies was evaluated by The Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies.ResultsFifteen studies met inclusion criteria, targeting social skills (n = 5), social cognitive skills (n = 7) and vocational training (n = 3). In these studies, a total of 292 participants enrolled in VR interventions and a total of 258 participants enrolled in control groups. In this systematic review, there were eight cohort studies, where seven were with a single-group pretreatment and posttreatment evaluation and one was with a control group, and one controlled trial and six randomized controlled trials were included. Several studies reported significant improvements in both psychosocial functioning and clinical symptoms, whereas others found improvements only in either psychosocial functioning or clinical symptoms, and still others found no improvements at all. The limitations of the studies include small sample sizes and standardized intervention methods. There is a very high variability in session duration, frequency and total treatment period.ConclusionAlthough VR intervention programs offer unique opportunities for psychosocial improvement, heterogeneity in methodologies and mixed results highlight the need for further research.