Browsing by Author "Baba, Cavid"

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Citation - WoS: 2
Citation - Scopus: 1
Comparative Analysis of Cognitive and Physical Characteristics in Late-Onset, Adult-Onset and Early-Onset Multiple Sclerosis Patients
(ELSEVIER SCI LTD, 2024) Özakbaş, Serkan; Kaya, Ergi; Aslan, Taha; Özdoğar, Asiye Tuba; Baba, Cavid
Background: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients. Methods: The study was conducted as a secondary analysis of a prospective study. The participants were divided into three groups according to age of MS onset: early onset (<18 years of age), adult-onset (20-40 years of age), and late-onset (>55 years of age). Demographic variables, oligoclonal bands, IgG index, and Expanded Disability Status Scale (EDSS) score in admission, first year, second year and current EDSS were evaluated. The Timed 25- Foot Walk Test (T25FW), Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12, Single Leg Standing Test, Activity-Specific Balance Confidence Scale, Nine-Hole Peg Test, Epworth Sleepiness Scale and Restless Legs Syndrome Severity Scale were performed. Appropriate statistical analysis was made. Results: A total of 658 pwMS was included in the study and divided into three groups: EOMS (n n = 117), AOMS (n n = 499), and LOMS (n n = 42). Statistically significant differences were determined between groups in terms of age [L (mean:59.86+5.45 +5.45 years-y-)> A (36.87+9.12 +9.12 y)> E (26.56 +8.85 y), p < 0.001], education level, current EDSS score (L L > E, p < 0.001), EDSS score in first admission, EDSS score in the first year, EDSS score in the second year (L L > A > E, p < 0.001), reached an EDSS score 6 (E E > L p = 0.001, E > A p = 0.015), disease duration (E E > A, E > L , mean E = 11.66+9.7 +9.7 y, A = 7.99+7.4 +7.4 y, L = 6.31+4.67 +4.67 y) time switching second-line treatment to the third line (E E > L p < 0.001, A > L p = 0.002, mean E = 171.73+83.29 +83.29 months-m-, A = 136.13+65.75 +65.75 m, L = 65.85 +45.96 m), number of relapses (A A > E > L , median E = 4.0, A = 3.0, L = 2.0), distribution of MS type and oligoclonal band types. Significant differences were found in T25FW and TUG. Post-hoc analysis showed that participants in the LOMS group have longer T25FW (mean L = 7.8 + 6.11, A = 6.25+5.09, +5.09, E = 5.72+3.13, +3.13, p = 0.011) and TUG (mean L = 11.01+5.53, +5.53, A = 9.57+8.04, +8.04, E = 8.38+5.51, +5.51, p = 0.007) times than the AOMS and EOMS groups. Conclusion: Our result revealed that individuals with LOMS face elevated disability levels and a heightened propensity to transition from first-line treatments to more advanced therapeutic interventions. LOMS have worse lower extremity functional status than AOMS and EOMS patient. Clinical evaluations and treatment choices require more attention in LOMS. However, according to the low number of LOMS in our cohort, these results were considered cautious, and more wide and multi-center studies must be designed.
CXCL13 as a Biomarker for Cognitive Impairment in Multiple Sclerosis: An Investigative Study
(Sage Publications Ltd, 2024) Yapici, Nurbanu; Baba, Cavid; Cevik, Sumeyye; Sagici, Ozge; Dogan, Yavuz; Ozakbas, Serkan
Does the Association of CXCL13 and CSF Profile in MS Support the Role of CXCL13 as a Potential Prognostic Biomarker
(Sage Publications Ltd, 2024) Yapici, Nurbanu; Cevik, Sumeyye; Baba, Cavid; Dogan, Yavuz; Ozakbas, Serkan
Does the Association of CXCL13 and CSF Profile in MS Support the Role of CXCL13 as a Potential Prognostic Biomarker?
(Sage Publications Ltd, 2024) Yapici, Nurbanu; Cevik, Sumeyye; Baba, Cavid; Dogan, Yavuz; Ozakbas, Serkan
[No abstract available]
Citation - WoS: 4
Citation - Scopus: 4
Dual-Task Difficulties as a Risk Factor for Unemployment in People With Multiple Sclerosis
(Wiley, 2023) Kahraman, Turhan; Temiz, Hasretgül; Abasıyanık, Zuhal; Baba, Cavid; Özakbaş, Serkan
Background: No study has investigated the impact of dual-tasking difficulties as a risk factor for unemployment in people with multiple sclerosis (pwMS). The aim was to examine the influence of dual-task performance on employment status and work difficulties and to identify the predictors of employment status in pwMS.Methods: Eighty-four pwMS, including 42 employed and 42 unemployed, participated in the study. Dual-task difficulties were assessed using the Dual-task Impact on Daily-living Activities-Questionnaire (DIDA-Q), while dual-task performance was evaluated through the 30-second Walk Test and Nine-Hole Peg Test, incorporating a cognitive task. Walking and cognitive function were also measured.Results: Employed pwMS had better scores in walking, cognitive function, single and dual-task performance than unemployed pwMS (p < .05). Lower scores in walking (odds ratio [OR] = 1.81, p < .001) and upper extremity-related (OR = 1.44, p = .019) dual-task performance and higher scores in the cognitive subscale of the DIDA-Q questionnaire (OR = 1.20, p = .037) were significantly associated with higher odds of being unemployed. Among employed pwMS, DIDA-Q subscales showed moderate-to-strong correlations with MSWSDQ-23 scores. The other variables showed weak-to-moderate correlations with subscale and total scores of MSWSDQ-23.Conclusion: Cognitive function, as opposed to motor function, has been found to be a significant predictor of unemployment in pwMS.
Impact of Early Treatment Modification on Long-Term Outcomes in Treatment-Naive Multiple Sclerosis Patients: Adverse Reactions and Compliance Challenges
(Sage Publications Ltd, 2024) Samadzade, Ulvi; Baba, Cavid; Simsek, Yasemin; Unal, Gozde Deniz; Kara, Irem; Ertekin, Ozge; Ozakbas, Serkan
The Oligoclonal Band Dilemma: Decoding Its Role in Predicting Relapsing-Remitting Multiple Sclerosis Progression
(Sage Publications Ltd, 2024) Baba, Cavid; Alizada, Said; Samadzade, Ulvi; Cevik, Sumeyye; Yapici, Nurbanu; Simsek, Yasemin; Ozakbas, Serkan
The Prognostic Role of Type 2 and Type 3 Oligoclonal Bands in Multiple Sclerosis: A Five-Year Clinical Outcome Comparison
(Sage Publications Ltd, 2025) Cevik, Sumeyye; Alizada, Said; Zengin, Ela; Samadzade, Ulvi; Yapici, Nurbanu; Baba, Cavid; Ozakbas, Serkan
Tracking Walking Capacity in People With Multiple Sclerosis Without Disability: 3-Year Follow-Up of Objective and Subjective Gait Measures
(Sage Publications Ltd, 2025) Abasiyanik, Zuhal; Baba, Cavid; Yigit, Pinar; Samadzade, Ulvi; Kahraman, Turhan; Ozakbas, Serkan
Yeni Teşhis Konulan Multipl Sklerozlu Bireylerde Servikal Omurilik Lezyonunun Üst Ekstremite Fonksiyonu Üzerindeki Etkisinin Değerlendirilmesi
(2025) Cinar, Bilge Piri; Ozakbas, Serkan; Kaya, Ergi; Baba, Cavid; Özdoğar, Asiye Tuba; Yapıcı, Nurbanu Aygündüz; Karakas, Hilal
Amaç: Çok erken evre multipl skleroz (MS) hastalarında servikal kord lezyonlarının üst ekstremite fonksiyonları üzerindeki etkisini değerlendirmek ve bu popülasyonda üst ekstremite fonksiyonlarını etkileyen faktörleri tanımlamak. Gereç ve Yöntem: Çalışmaya 245 ilk semptomlardan 24 ay geçmiş ve 378 tanıdan sonraki altı ay içinde hastalık modifiye edici tedaviye (DMT) başlamış MS’li bireyler dahil edilmiştir. Üst ekstremite fonksiyonlarını değerlendirmek için Dokuz Çivi Peg Testi (N-HPT) uygulanmıştır. Servikal kord lezyonunun varlığına göre katılımcılar iki gruba ayrıldı. Bulgular: Gruplar arasında yaş, cinsiyet, hastalık süresi ve atak sayısı açısından anlamlı bir fark bulunmamıştır. Ancak, toplam Genişletilmiş Engellilik Durumu Ölçeği (EDSS) skoru, piramidal ve duyusal fonksiyonel sistem skorları, servikal kord lezyonları olan MS’li bireylerde olmayanlara göre daha yüksek bulunmuştur. Tanıdan sonraki altı ay içinde DMT başlatılan katılımcılarda, dominant ve ortalama N-HPT performans süreleri, servikal kord lezyonu olan MS’li bireylerde olmayanlara göre anlamlı derecede daha uzun bulunmuştur. Ancak, ilk semptomlardan 24 ay sonra tanı konulan katılımcılar arasında gruplar arasında anlamlı bir fark gözlenmemiştir. Yaş, hastalık süresi ve tanıdan tedaviye kadar geçen süre, N-HPT performansını etkileyen önemli faktörler olarak belirlenmiştir. Daha genç, daha kısa hastalık süresine sahip ve tanı sonrası daha erken tedavi alan MS’li bireyler, diğerlerine göre daha iyi performans göstermiştir. Sonuç: Çalışmamız, MS’in erken evrelerinde bile servikal kord lezyonlarının üst ekstremite fonksiyonları üzerindeki etkisini vurgulamakta ve erken tanı ile DMT’lerin hızlı bir şekilde başlatılmasının önemini ortaya koymaktadır.