Browsing by Author "Babiloni, C."

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Basic Science and Pathogenesis
(2024) Noce, G.; Percio, C.D.; Lizio, R.; Lopez, S.; Jakhar, D.; Güntekin, B.; Babiloni, C.
BACKGROUND: Parkinson's disease and Huntington's disease are both neurodegenerative conditions involving the basal ganglia area of the brain. Both conditions can cause symptoms that affect movement. Cognitive decline or dementia can also occur in both. Resting state EEG (rsEEG) rhythms reflect neurophysiological mechanisms and operational functions related to the fluctuation of brain arousal and quiet vigilance in humans. The hypothesis was that rsEEG sources may be more abnormal in Huntington's disease patients in symptomatic stage (S-HD) than patients with dementia due to Parkinson's disease. METHOD: Clinical and rsEEG datasets in 16 PDD, 18 S-HD, and 25 matched cognitively unimpaired (Nold) participants - matched as demography, education, and gender - were taken from an international archive. The eLORETA freeware was used to estimate cortical rsEEG sources at delta, theta, alpha1, alpha2, alpha3, beta1, beta2, and gamma frequency bands. RESULT: Results showed lower amplitude of the posterior alpha activities and higher amplitude of widespread low frequencies bands (i.e., delta and theta) in the PDD and S-HD groups than in the Healthy group. As compared to the PDD group, the S-HD showed greater reductions in the rsEEG alpha 2 rhythms in the frontal and temporal regions (see Figure 1). CONCLUSION: These results suggest that cortical sources of rsEEG rhythms might reflect different abnormalities of the core neurophysiological mechanisms underlying brain arousal in quiet wakefulness and low vigilance in PDD, and S-HD patients. The mentioned rsEEG markers might be clinically useful in the disease staging, monitoring over time, and drug discovery. © 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Citation - WoS: 7
Citation - Scopus: 7
Lower Oddball Event-Related Eeg Delta and Theta Responses in Patients With Dementia Due To Parkinson's and Lewy Body Than Alzheimer's Disease
(Elsevier Inc., 2024) Yıldırım, E.; Aktürk, T.; Hanoğlu, L.; Yener, Görsev; Babiloni, C.; Güntekin, B.
Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EEG delta and theta responses in patients with PDD, DLB, and Alzheimer's disease dementia (ADD). During visual and auditory oddball paradigms, EEG activity was recorded in 20 ADD, 17 DLB, 20 PDD, and 20 healthy (HC) older adults. Event-related EEG power spectrum and phase-locking analysis were performed at the delta (1–4 Hz) and theta (4–7 Hz) frequency bands for target and nontarget stimuli. Compared to the HC persons, dementia groups showed lower frontal and central delta and theta power and phase-locking associated with task performance and neuropsychological test scores. Notably, this effect was more significant in the PDD and DLB than in the ADD. In conclusion, oddball task-related frontal and central EEG delta and theta responses may reflect frontal supramodal executive dysfunctions in PDD and DLB patients. © 2024 Elsevier Inc.
Citation - WoS: 2
Citation - Scopus: 2
Poor Reactivity of Posterior Electroencephalographic Alpha Rhythms During the Eyes Open Condition in Patients With Dementia Due To Parkinson's Disease
(Elsevier Inc., 2024) Babiloni, C.; Noce, G.; Tucci, F.; Jakhar, D.; Ferri, R.; Panerai, S.; Catania, V.; Yener, Görsev
Here, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources. Results showed substantial (greater than −10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the PDD group than in the healthy control seniors and the ADD patients. These results suggest that PDD patients show poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. That neurophysiological biomarker may provide an endpoint for (non) pharmacological interventions for improving vigilance regulation in those patients. © 2023 The Authors
Citation - Scopus: 1
Qeeg Methods To Probe Abnormal Brain Rhythms Related To Quiet Vigilance in Patients With Dementia Due To Alzheimer’s, Parkinson’s, and Lewy Body Diseases
(Humana Press Inc., 2024) Babiloni, C.; Güntekin, B.; Yener, Görsev; Del, Percio, C.
Here, we discuss relevant literature findings on abnormal resting-state scalp-recorded electroencephalographic (rsEEG) rhythms in old patients with severe cognitive deficits and disabilities in activities of daily living (i.e., dementia) due to Alzheimer’s (ADD), Parkinson’s (PDD), and Lewy body (DLB) neurodegenerative diseases. Furthermore, we described a modern quantitative EEG (qEEG) methodology to explore those rhythms and related vigilance disorders. The reviewed findings unveil consistent abnormalities in topographic and frequency (most in <12 Hz) features of the rsEEG rhythms recorded in ADD, PDD, and DLB patients, probably reflecting altered neurophysiological oscillatory mechanisms of synchronization and functional connectivity in neural brain populations underpinning the regulation and maintenance of the quiet vigilance. The proposed qEEG methodology showed significant differences in the posterior cortical sources of rsEEG alpha rhythms at individual frequencies among small groups of ADD, PDD, and DLB patients. Although the above abnormalities may have a limited diagnostic value at the individual level, not specifically reflecting the neuropathological processes underlying ADD, PDD, and DLB, they have significant heuristic and clinical relevance. Namely, the rsEEG readouts at the alpha frequencies unveiled the altered neurophysiological oscillatory mechanisms responsible for vigilance disorders in ADD, PDD, and DLB patients and may be used as pathophysiological biomarkers to evaluate the efficacy of (non)pharmacological interventions to treat those disorders. We recommend using the present qEEG methodology in longitudinal rsEEG studies carried out in ADD, PDD, and DLB patients to explore the abnormalities in the rsEEG biomarkers of vigilance dysregulations during the disease progression. © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Citation - WoS: 8
Citation - Scopus: 12
Resting State Electroencephalographic Alpha Rhythms Are Sensitive To Alzheimer's Disease Mild Cognitive Impairment Progression at a 6-Month Follow-Up
(Elsevier Inc., 2024) Babiloni, C.; Jakhar, D.; Tucci, F.; Del, Percio, C.; Lopez, S.; Soricelli, A.; Salvatore, M.; Yener, Görsev
Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ≥ −10% and −10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups. © 2024 The Authors