Browsing by Author "Caliskan, Can"
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Conference Object The 6-Minute Threshold: Tracking Three-Year Disability and Cognition in Multiple Sclerosis(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Caliskan, Can; Zengin, Ela; Ozakbas, SerkanConference Object Age Matters: Distinct Disability Patterns in Multiple Sclerosis Patients Initiating Therapy After the Age of 50(Sage Publications Ltd, 2025) Zengin, Ela; Caliskan, Can; Simsek, Yasemin; Unal, Gozde Deniz; Ozakbas, SerkanConference Object Clinical Characteristics and Disease Progression in Multiple Sclerosis: A Comparison of Late Middle-Age Onset vs Late Adulthood Onset(Sage Publications Ltd, 2025) Ozakbas, Serkan; Simsek, Yasemin; Caliskan, Can; Ozdogar, Asiye TubaConference Object Cognitive Decline as the First Sign of Progression in Multiple Sclerosis: A Comparative Analysis of Cognitive and Physical Decline(Sage Publications Ltd, 2025) Ozakbas, Serkan; Basaran, Tuncay; Unal, Gozde Deniz; Caliskan, Can; Aydin, Esra; Kara, Irem; Zengin, ElaConference Object Cognitive Profiles of Relapsing Multiple Sclerosis Patients With Progression Independent of Relapse Activity Versus Non-NEDA Status(Sage Publications Ltd, 2025) Alizada, Said; Ozdogar, Asiye Tuba; Samadzade, Ulvi; Caliskan, Can; Ozakbas, SerkanConference Object Cognitive Stability Over Three Years Despite Loss of Ambulation in Progressive Multiple Sclerosis With Preserved Upper Limb Function(Sage Publications Ltd, 2025) Samadzade, Ulvi; Unal, Gozde Deniz; Caliskan, Can; Aydin, Esra; Ozakbas, SerkanConference Object Do Multiple Sclerosis Patients Perceive the Effectiveness of Relapse Treatment? A Comprehensive Evaluation Through the Expanded Disability Status Scale and Patient Determined Disease Steps Correlation(Sage Publications Ltd, 2025) Caliskan, Can; Unal, Gozde Deniz; Zengin, Ela; Ozakbas, SerkanConference Object Earlier Decline in Upper Limb Function Than Gait in Multiple Sclerosis: A Five-Year Longitudinal Study(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Samadzade, Ulvi; Aydin, Esra; Caliskan, Can; Ozakbas, SerkanConference Object Elevated IgM Index Is Linked to More Severe Cognitive Impairment in Multiple Sclerosis(Sage Publications Ltd, 2025) Samadzade, Ulvi; Caliskan, Can; Unal, Gozde Deniz; Kara, Irem; Aydin, Esra; Ozakbas, SerkanConference Object Enhancing Fine Motor Assessment: The 9HPT-Extended as a Superior Alternative to the Standard 9HPT(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Aydin, Esra; Caliskan, Can; Samadzade, Ulvi; Ozdogar, Asiye Tuba; Kahraman, Turhan; Ozakbas, SerkanConference Object Evaluating the Ability of PDDS to Reflect Motor Function in Multiple Sclerosis: Comparison With EDSS and the Timed Up and Go Test(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Caliskan, Can; Samadzade, Ulvi; Ozakbas, SerkanConference Object Evaluating the Impact of MS Medications on Pregnancy Outcomes: A Retrospective Cohort Study(Sage Publications Ltd, 2024) Kaya, Ergi; Simsek, Yasemin; Ozcelik, Sinem; Caliskan, Can; Ozakbas, SerkanConference Object Evaluation of Disability in Individuals with Multiple Sclerosis Using Clinician-Rated and Patient-Reported Measures: A Cross-Sectional and Retrospective Study(Sage Publications Ltd, 2025) Caliskan, Can; Simsek, Yasemin; Samadzade, Ulvi; Ozakbas, SerkanConference Object Exploring Familial Multiple Sclerosis: Insights From a Cohort Analysis(Sage Publications Ltd, 2024) Ozakbas, Serkan; Simsek, Yasemin; Caliskan, Can; Ozcelik, SinemArticle Familial Multiple Sclerosis Is Associated With Accelerated Progression to Secondary Progressive Phase: A Retrospective Single-Center Cohort Study(Springer Heidelberg, 2025) Ozakbas, Serkan; Alizada, Said; Caliskan, Can; Simsek, Yasemin; Zengin, Ela SimayBackground Familial multiple sclerosis (MS), defined by the occurrence of MS in one or more relatives, is thought to represent a genetically influenced subtype of the disease. Objective To compare clinical progression, cerebrospinal fluid (CSF) parameters, and treatment responses between familial and sporadic MS patients. Methods We conducted a retrospective analysis of 1,035 patients diagnosed with MS according to the 2017 McDonald criteria (523 familial, 512 sporadic). Demographic variables, MS subtypes, expanded disability status scale (EDSS) scores, CSF oligoclonal band (OCB) status, IgG index, and treatment regimens were evaluated. Statistical tests included t tests, chi-square, and multivariable regression. Results Familial MS patients showed a higher incidence of secondary progressive MS (10.9%) compared to sporadic cases (7.0%, p = 0.030). Disease duration was significantly longer in familial MS (14.5 vs. 12.3 years, p < 0.01) though time to diagnosis did not differ. OCB positivity rates were comparable, but the IgG index was significantly elevated in familial MS (p < 0.01). Treatment responses did not differ between groups. Conclusion Familial MS is associated with more rapid disease progression and enhanced humoral immune activation, suggesting a distinct phenotype. These findings support the need for genetic and immunologic investigations to guide personalized treatment strategies.Conference Object Familial Multiple Sclerosis: Unveiling Disease Progression and Clinical Correlates(Sage Publications Ltd, 2024) Simsek, Yasemin; Alizada, Said; Caliskan, Can; Ozakbas, SerkanConference Object Familial Patterns and Clinical Correlates of Neuromyelitis Optica: Insights From a Cohort Study(Sage Publications Ltd, 2024) Ozakbas, Serkan; Caliskan, Can; Simsek, Yasemin; Zengin, ElaConference Object Fine Motor Function as a Potential Indicator of Cognitive Status in Multiple Sclerosis: A Cross-Sectional Study(Sage Publications Ltd, 2025) Unal, Gozde Deniz; Caliskan, Can; Kara, Irem; Aydin, Esra; Yapici, Nurbanu; Ozakbas, SerkanConference Object Five Years of Ocrelizumab in MS: Clinical Stability and Subtle Cognitive Gains(Sage Publications Ltd, 2025) Ozakbas, Serkan; Samadzade, Ulvi; Unal, Gozde Deniz; Caliskan, Can; Kara, Irem; Alizada, SaidConference Object Five-Year Real-World Outcomes of Fingolimod in Multiple Sclerosis: Long-Term Effectiveness and Treatment Continuation Patterns(Sage Publications Ltd, 2025) Ozakbas, Serkan; Alizada, Said; Samadzade, Ulvi; Caliskan, Can
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