Browsing by Author "Cilengiroglu, Ozgul Vupa"

Now showing 1 - 2 of 2

Comparative Analysis of Onabotulinum Toxin Type-A Injection Techniques in Older Adults With Blepharospasm: A Retrospective Cohort Study
(Frontiers Media S.A., 2025) Poyraz, Turan; Cilengiroglu, Ozgul Vupa
Introduction: Benign essential blepharospasm (BEB) is a focal dystonia that can lead to functional blindness in older adults. While botulinum neurotoxin (BoNT) is widely utilized in the treatment of BEB, there remains a lack of consensus regarding the optimal injection technique. This study aims to compare the clinical outcomes and measurable scales associated with injections into the orbicularis oculi muscle at the pars pretarsalis (PPT) and pars preseptalis (PPS) regions, assessing their efficacy and side effects. Methods: The study included 32 patients diagnosed with BEB. Two injection techniques utilizing onabotulinum toxin type-A-PPT and PPS-were compared. The modified Jankovic Scale (mJS) was used to assess the clinical severity and frequency of blepharospasm. At the same time, the Blepharospasm Disability Scale evaluated the associated disabilities. The Schirmer I test was used to assess dry eye symptoms post-BoNT administration. Adverse effects were self-reported, and participants were examined at 1- and 3-month follow-up. Results: Both injection techniques resulted in significant improvements in the mJS severity and frequency scores, as well as the Blepharospasm Disability Scale (p < 0.05). Notably, improvements in ocular dryness were particularly pronounced at the 1-month mark (p < 0.05). The PPT injection technique displayed a superior safety profile, with the total number of adverse events statistically greater in the PPS group compared to the PPT group (p < 0.05). Conclusion: BoNT injections through both PPT and PPS techniques are effective in treating BEB in older adults. However, the PPT technique demonstrates a lower incidence of adverse events, rendering it a preferable choice for clinicians managing BEB.
Citation - WoS: 3
A Comparative Study on Indoor Radon Levels Between the Lung Cancer and Cancer Free Groups in Izmir Province, Turkey
(Dokuz Eylul Univ Inst Health Sciences, 2021) Ozbay, Turkan; Karadeniz, Ozlem; Cilengiroglu, Ozgul Vupa; Durak, Hatice; Eser, Sultan
Purpose: Izmir is the province of Turkey with the highest lung cancer incidences for males, therefore a comparative study was performed in particular districts of Izmir in 2013. In the study, it was aimed to assess the association between lung cancer risk and indoor radon. Methods: Patients diagnosed with lung cancer between 2010 and 2011 were selected from the database of the Izmir Cancer Registry (ICR). Measurements of indoor radon concentrations were performed in a total of 117 locations using the SSNTD (Solid State Nuclear Track Detectors) method with LR-115 detectors. Indoor radon concentration measured in homes of patients with lung cancer and cancer free group were compared statistically. Results: The indoor Radon (222Rn) activity concentration detected ranged from 165 to 487 Bq/m3, for the lung cancer group, from 28 to 367 Bq/m(3) for the cancer free group, with geometric means of 269 Bq/m3 and 123 Bq/m(3), respectively. Conclusion: According to the logistic regression model, as radon concentration and package/year increased, the rate of cancer increased multiple folds. These results suggest that indoor radon levels may contribute to higher rates of lung cancer for Izmir compared to the rest of the country, and indoor radon levels may be a contributory factor in this phenomenon.