Browsing by Author "Colakoglu, Berril Donmez"

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Citation - WoS: 12
Citation - Scopus: 12
Reduced Power and Phase-Locking Values Were Accompanied by Thalamus, Putamen, and Hippocampus Atrophy in Parkinson?s Disease With Mild Cognitive Impairment: an Event-Related Oscillation Study
(Elsevier Science Inc, 2023-01) Hunerli-Gunduz, Duygu; Isbitiren, Yagmur Ozbek; Uzunlar, Hakan; Cavusoglu, Berrin; Colakoglu, Berril Donmez; Adag, Emel; Yener, Görsev; Özbek İşbitiren, Yağmur; Ada, Emel
Parkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive im-pairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to re-flect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants us-ing visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysio-logical, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological ab-normalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atro-phy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI. (c) 2022 Elsevier Inc. All rights reserved.
Citation - WoS: 3
Citation - Scopus: 3
Structural and Functional Changes in Mild Cognitive Impairment in Parkinson's Disease
(Mdpi, 2023-12-24) Güllüoğlu, Halil; Hünerli, Duygu; Çakmur, Raif; Dönmez Çolakoğlu, Berril; Ada, Emel; Yener, Gorsev; Colakoglu, Berril Donmez
Background and Objectives: The pathophysiology of mild cognitive impairment in Parkinson's disease (PD-MCI) is still not fully elucidated. It has been shown in a few studies in the literature that volume loss in the occipital, parietal and frontal cortices and atrophy in the hippocampus of PD-MCI patients can occur in the early stages of PD. The aim of this study was to evaluate the relationship between gray and white matter volumes and different neuropsychological tests and volumetric magnetic resonance imaging parameters in patients with mild cognitive impairment in Parkinson's disease (PD-MCI). Materials and Methods: Twenty-six PD-MCI and twenty-six healthy elderly (HC) were included in this study. Results: We found that Mini Mental State Examination, Trail Making Test Part A, Clock Drawing Test, Benton Line Judgment Orientation Test and pentagon figure-copying scores were impaired in PD-MCI patients due to the decrease in brain volumes. Conclusions: Our study revealed that among PD-MCI patients, there was a more noticeable decline in White matter volume (WMV) based on volumetric Magnetic Resonance Imaging (MRI) compared to the localized loss of GMV. We think that these abnormal neuropsychological tests in PD-MCI patients can be used as pretests in the evaluation of the stage of transition to dementia.