Browsing by Author "Coskun, Fatma"

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Hypothalamic-Pituitary-Adrenal Axis Activity and Neurotrophic Factors in Drug-Naive Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
(Frontiers Media SA, 2026-03-11) Ferahkaya, Hursit; Kilinc, Ibrahim; Uzun, Necati; Akkus, Abdullah; Bilgic, Ayhan; Coskun, Fatma; Agir, Hasibe
Background Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a complex and not fully understood etiology. Increasing evidence suggests that neurotrophic factors involved in neurodevelopment and synaptic plasticity, as well as hormones of the hypothalamic-pituitary-adrenal (HPA) axis that regulate the stress response, may contribute to the pathophysiology of ADHD.Methods This cross-sectional study aimed to compare children diagnosed with ADHD and healthy controls with respect to serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), neurotrophin-3 (NT-3), adrenocorticotropic hormone (ACTH), and cortisol. A total of 80 children aged 6-18 years with a diagnosis of ADHD and 81 healthy controls were included in the study. The severity of ADHD symptoms was assessed using the Conners' Parent Rating Scale-Short Version (CPRS-SV). Serum levels of biochemical parameters were measured using commercially available electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay kits.Results Compared with the healthy control group, the ADHD group exhibited significantly higher serum levels of BDNF, GDNF, VEGF, ACTH, and cortisol, whereas NT-3 levels did not differ between the groups. These group differences remained statistically significant after controlling for potential confounding variables. Correlation analyses revealed no significant associations between neurotrophic factors, hypothalamic-pituitary-adrenal (HPA) axis hormones, and CPRS-SV subscale scores.Conclusions The present findings indicate that neurotrophic factors and hormones related to the hypothalamic-pituitary-adrenal (HPA) axis are altered in medication-na & iuml;ve children and adolescents with ADHD. The absence of a direct correlation between neurotrophic factors and HPA axis hormones suggests that these systems may contribute to the pathophysiology of ADHD through parallel yet partially independent and complex mechanisms. Future longitudinal and multimodal studies are warranted to elucidate the dynamic interactions between stress-related neuroendocrine processes and neurodevelopmental pathways in ADHD.
The Reliability and Validity of the Personalıty Inventory for DSM-5-Short Form (PID-5-SF) in Turkish Adolescents
(Guilford Publications Inc, 2026-02) Bilgic, Ayhan; Coskun, Fatma; Akca, Omer Faruk; Sharp, Carla
The 100-item short form of the Personality Inventory for DSM-5 (PID-5-SF) has been translated into various languages and validated across cultures and age groups, but research on adolescents is limited. This study evaluated the psychometric properties of the Turkish version (PID-5-SF-TR) in a sample of 349 adolescents (181 community, 168 clinical). Participants also completed the Personality Belief Questionnaire-Short Form (PBQ-SF) and the Big Five Inventory (BFI). Clinical participants had higher facet scores than community participants. Exploratory factor analysis revealed a five-factor structure for both groups. Cronbach's alpha coefficients ranged from 0.72 to 0.86 in the clinical group and from 0.73 to 0.87 in the community group. PID-5-SF-TR domains correlated significantly with related BFI dimensions, except for Openness and Psychoticism. Corresponding PBQ-SF and PID-5-SF-TR subscales were significantly correlated. Test-retest reliability over 5 months showed coefficients ranging from r = 0.30 to r = 0.67. Findings support the reliability and validity of using the PID-5-SF-TR when diagnosingTurkish adolescents.