Browsing by Author "Del, Percio, C."

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    Qeeg Methods To Probe Abnormal Brain Rhythms Related To Quiet Vigilance in Patients With Dementia Due To Alzheimer’s, Parkinson’s, and Lewy Body Diseases
    (Humana Press Inc., 2024) Babiloni, C.; Güntekin, B.; Yener, Görsev; Del, Percio, C.
    Here, we discuss relevant literature findings on abnormal resting-state scalp-recorded electroencephalographic (rsEEG) rhythms in old patients with severe cognitive deficits and disabilities in activities of daily living (i.e., dementia) due to Alzheimer’s (ADD), Parkinson’s (PDD), and Lewy body (DLB) neurodegenerative diseases. Furthermore, we described a modern quantitative EEG (qEEG) methodology to explore those rhythms and related vigilance disorders. The reviewed findings unveil consistent abnormalities in topographic and frequency (most in <12 Hz) features of the rsEEG rhythms recorded in ADD, PDD, and DLB patients, probably reflecting altered neurophysiological oscillatory mechanisms of synchronization and functional connectivity in neural brain populations underpinning the regulation and maintenance of the quiet vigilance. The proposed qEEG methodology showed significant differences in the posterior cortical sources of rsEEG alpha rhythms at individual frequencies among small groups of ADD, PDD, and DLB patients. Although the above abnormalities may have a limited diagnostic value at the individual level, not specifically reflecting the neuropathological processes underlying ADD, PDD, and DLB, they have significant heuristic and clinical relevance. Namely, the rsEEG readouts at the alpha frequencies unveiled the altered neurophysiological oscillatory mechanisms responsible for vigilance disorders in ADD, PDD, and DLB patients and may be used as pathophysiological biomarkers to evaluate the efficacy of (non)pharmacological interventions to treat those disorders. We recommend using the present qEEG methodology in longitudinal rsEEG studies carried out in ADD, PDD, and DLB patients to explore the abnormalities in the rsEEG biomarkers of vigilance dysregulations during the disease progression. © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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    Resting State Electroencephalographic Alpha Rhythms Are Sensitive To Alzheimer's Disease Mild Cognitive Impairment Progression at a 6-Month Follow-Up
    (Elsevier Inc., 2024) Babiloni, C.; Jakhar, D.; Tucci, F.; Del, Percio, C.; Lopez, S.; Soricelli, A.; Salvatore, M.; Yener, Görsev
    Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ≥ −10% and −10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups. © 2024 The Authors