Browsing by Author "Dogruyol, Sinem"

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Can Spesific Biomarkers Be Used To Enlighten the Major Mechanisms of Acute High Dose Diclofenac Sodium-Related Nephrotoxicity?
(Galenos Publ House, 2022) Dogruyol, Sinem; Akbas, Ilker; Kocak, Abdullah Osman; Aygormez, Serpil; Leylek, Habip Emrah; Gur, Sultan Tuna Akgol; Ertener, Ozge
Aim: The aim of this study was to examine the basic mechanisms that play a role in the acute nephrotoxicity caused by diclofenac sodium. Materials and Methods: Only water was given to the control group; however, the diclofenac sodium group was group intoxicated by giving water-soluble, 240 mg/kg, oral single dose diclofenac sodium. After 24 hours, all animals were sacrificed and histopathological analyzes were performed. The levels of spesific biomarkers [vascular endothelial growth factor (VEGF), nuclear factor-kappa B (NF-kappa B), matrix metalloproteinase-9 (MMP-9), metalloproteinase tissue inhibitor-1 (TIMP-1) and carcinoembryonic antigen (CEA)] that may be related to the nephrotoxicity mechanism were evaluated. Results: As a result of biochemical analysis, we found that VEGF, TIMP-1, NF-kappa B and CEA levels were significantly higher and MMP-9 levels were significantly lower in diclofenac sodium group compared to control group. Nephrotoxicity related histopathological changes were observed in the sections of diclofenac sodium group. Conclusion: This study has shown that the biomarkers we evaluated in the diclofenac sodium-induced acute high-dose intoxication model we created can help us to identify the nephrotoxicity and to explain the nephrotoxicity mechanism with the three main steps (the hemodynamicrelated pathway, the inflammation-related pathway, and the oxidative stress-related pathway). With a simple version of this panel adapted to emergency departments, we may be able to diagnose diclofenac sodium-related nephrotoxicity.
Is It Possible To Have a Risk Scoring System That Provides Early Warning of the Poor Prognosis in Covid-19?
(2022) Acar, Burak; Akbaş, İlker; Koçak, Abdullah Osman; Dogruyol, Sinem; Özcan, Sinem
Objective: In our study, we aimed to determine the factors associated with poor outcome by evaluating the data of possible/definite Coronavirus 2019 (COVID-19) cases coming to the emergency department in two centers and to establish a risk scoring system. Methods: This study has been designed as a retrospective study performed on COVID-19 cases. Patients’ sociodemographic data, complaints, vital signs, laboratory parameters, ser- vice/intensive care admission status, and the presence of death were analyzed. Results: A total of 436 patients were included in the study. We divided the cases into two groups in terms of poor outcome. The factors associated with poor outcome such as the presence of comorbid disease (p=0.001), being 50 years and older (p<0.001), symptoms of shortness of breath (p<0.001), saturation value <95% (p<0.001), neutrophil count >7×109 L–1 (p=0.006), lymphocyte count <1.1×109 L –1 (p=0.020), procalcitonin value ?0.015 ng/mL (p=0.001), D-dimer value ?500 mg/L (p=0.009) were found to be statistically significant. Conclusion: The scoring system we have created is considered to be a comprehensive, eas- ily applicable, and reliable method in determining the prognosis and the treatment strategy.