Browsing by Author "Ekinci, Ferhat"

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The Confusion Caused by the Fear of Covid 19 in the Future of Cancer Patients
(Ibn Sina Trust, 2023-01-01) Ekinci, Ferhat; Ates, Gonca Akdere; Erdogan, Atike Pinar; Celik, Cumali; Dirican, Ahmet; Goksel, Gamze
Objective: The centrality of events scale (CES) was formed to determine to what extent this localisation cancer disease was by fear of COVID-19 in cancer patients or how centralised the cognitive trauma was in this patient group.Materials and Methods: In the first paragraph of the short 7-item CES, it was written, Please think about the most stressful or traumatic event in your life, then 3 options were given. These and C) Other. After marking one of these options, the subjects were instructed to mark their level of agreement with the 7 items as stated by Berntsen and Rubin, and thus this section was the same as the original questionnaire. To be able to evaluate the questionnaire results taking the disease characteristics into account, a record was made of age, gender, treatment history (chemotherapy and radiotherapy), spread, local, metastatic).The questionnaires were administered to all the cancer patients who presented at the oncology clinic between 1 April and 1 October 2020.Results:This study was conducted to seek an answer to this question, and it was seen that of a total of 523 patients diagnosed with cancer, the vast majority (n:368, 70.4%) saw the most traumatic and stressful event of their life as cancer, with the response to option A on the questionnaire. The possibility of contracting COVID-19 was selected by 83 (15.9%) patients as the most stressful or traumatic event in their life. The option of C was marked by 72 (13.8%) patients. This showed that neither cancer nor fear of coronavirus infection was strong enough to replace the traumatic event experienced and centred in the identity of these 72 patients. These traumas of the patients were analyzed with the mean CES points. The highest points were obtained by those who marked option A, at 3.71, which was statistically significantly higher than the 3.29 points for B and 3.29 points for C (p:0.004).Conclusion:A trauma left in the past actually lives on in the cognitive memory and may even be established at the centre of the self and personal identity. Thus, by modifying the short 7-item CES, developed by Berntsen and Rubin to be an objective, measurable format, the results of this study demonstratated both the extent to which the possibility of contracting COVID-19 has started to be established in cancer patients and the unshakable but declining centrality of cancer in the traumatic past.
Citation - WoS: 7
Citation - Scopus: 8
Could the Inflammatory Prognostic Index Predict the Efficacy of Regorafenib in Patients With Metastatic Colorectal Cancer?
(Springer, 2021-04-21) Erdogan, Atike Pinar; Ekinci, Ferhat; Karabas, Aykut; Balcik, Onur Yazdan; Barutca, Sabri; Dirican, Ahmet
Purpose To investigate the clinical importance of the inflammatory prognostic index (IPI) in patients with metastatic colorectal cancer treated with regorafenib. Methods A retrospective analysis of 65 metastatic CRC patients treated with regorafenib between 2015 and 2020 was performed. The association between NLR, PNLR, IPI, and overall survival (OS) and progression-free survival (PFS) was evaluated. Results According to the cut-off points, patients were divided into two groups. The patients in the high IPI group showed poorer OS compared to patients in the low IPI groups. The PFS was better in patients with low neutrophil-lymphocyte ratio (NLR) and platelet-neutrophil to lymphocyte ratio (PNLR), and the OS was better in patients with low IPI. Conclusion Among the immune inflammation scores analyzed in mCRC patients receiving regorafenib, NLR and PNLR were the best predictor of recurrence, whereas IPI was the best predictor of long-term survival. After being confirmed by better designed controlled trials, IPI can be used to identify the group of patients who will benefit more from regorafenib treatment.
The Value of Inflammatory Prognostic Index in Older Patients With Hormone Receptor Positive Metastatic Breast Cancer
(2022) Oktay, Esin; Sahin, Mustafa; Erdogan, Atike Pinar; Ozveren, Ahmet; Yilmaz, Senem; Ekinci, Ferhat; Demir, Bilgin; Goksel, Gamze
Objectives: To search the prognostic value of an inflammation based prognostic score in older patients with hormone positive, Her2 negative metastatic breast cancer. Methods: A retrospective study of 82 female patients aged 65 years and older with hormon receptor positive, Her-2 negative metastatic breast cancer diagnosed between 2011 and 2018 was conducted with collection of clinical and laboratory data. The inflammatory prognostic index (IPI) was calculated as C-reactive protein × NLR (neutrophil/ lym- phocyte ratio)/serum albumin. Survival estimates were calculated with Kaplan-Meier method. Results: The optimal cut-off points of IPI for the stratification of OS was found to be 0,75. Based on this cutoff value, patients were categorized as IPI-high and IPI-low group. High IPI was significantly associated with advanced stage at diagnosis. (p=0.03) The mean OS was 64 months in the IPI-high group and 66.9 months in the IPI-low group. (p=0,813) In patients receiving hormonotherapy in first line treatment PFS was 34.6 months in the IPI-low group and 14.5 months in the IPI high group, and a statistically significant difference was found compared to patients who received chemo- therapy in the first line. (p=0,042). Conclusion: Measurement of systemic inflammatory response in older adults with metastatic breast cancer is reliable, available, and can be clinically incorporated into current geriatric oncology algorithms
Citation - Scopus: 1
Vinorelbine Induced Serpentine Supravenous Hyperpigmentation
(Türkiye Klinikleri, 2022) Yetut, Ahsen Duygu; Dirican, Ahmet; Çelik, Cumali; Erdogan, Atıke Pınar; Taş, Semra; Ekinci, Ferhat
Serpentine supravenous hyperpigmentation (SSH) is a rare complexity arising from antineoplastic therapy. Vinorelbine, a\rchemotherapeutic drug that is frequently used for the treatment of breast and lung cancer, contributes to the etiology of SSH. A 54 years old\rmale patient was being treated for lung adenocarcinoma. An intravenous (IV) infusion of vinorelbine was administered in the distal dorsal vein\rof the left forearm. Erythematous hyperpigmentation at the infusion area was observed a week after the administration of the chemotherapeutic\rdrug. The initial symptoms of SSH usually appear between 1 to 15 days post IV administration of a cytotoxic drug, and it spontaneously becomes\rhyperpigmented within 1-3 weeks. However, these local reactions can be prevented by applying IV infusion for a short period (15-30\rmin) along with adequate venous irrigation (75-124 mL) instead of bolus administration. The termination of the drug can also be considered.