Browsing by Author "Gülseren, Varol"

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Investigation of the Predictive Factors of Recurrent Ovarian Mucinous Cystadenoma
(2024) Özcan, Aykut; Balikoglu, Meric; Alkan, Kaan Okan; Gülseren, Varol
OBJECTIVE: Rapid growth patterns and recurrence with variable rates have been reported in the liter- ature, making mucinous cystadenomas different from other ovarian benign neoplasms. The study aimed to predict and prevent recurrence based on the obtained results. STUDY DESIGN: In this case-control study among the 2,341 patients who underwent surgery for ovar- ian cysts, 221 met the inclusion criteria. The 221 patients diagnosed with mucinous cystadenoma were categorized into two groups: 14 patients (6.3%) with recurrence and 207 patients (93.7%) without re- currence. Patients in these groups were compared in terms of demographic characteristics, ovarian cyst size, operative technique, type of surgery (oophorectomy or cystectomy), Ca19-9, CA125, and CEA val- ues of the patients, and duration of postoperative follow-up. RESULTS: The mean age was statistically lower in the group with recurrence (27±5 vs 44±14; p<0.001). The follow-up period of recurrent cases was significantly longer (6.8 ± 3.5 vs 4.9 ± 2.2 years; p=0.045). The recurrence rate was significantly higher in patients who underwent cystectomy (p<0.001; odds ratio: 22.8). When all patients were examined, cystectomy was preferred in younger patients [31 (18-65) vs 48 (18-81); p<0.001]. According to regression analysis, cystectomy alone is an independent risk factor (p=0.041). CONCLUSION: Unlike conventional ovarian cystadenomas, mucinous cystadenomas should be fol- lowed up owing to the possibility of recurrence, especially when detected at an early age. Since cys- tectomy is the only independent risk factor, oophorectomy should be the primary treatment for patients >40 years of age who have no desire for childbearing.
Recurrence and Characteristics of Endometrial Cancer in Elderly Patients
(2024) Gülseren, Varol; Çakır, İlker; Kuru, Oğuzhan; Gökçü, Mehmet; Özcan, Aykut; Sancı, Muzaffer; Emiralioğlu Çakı, Zübeyde
Objective: This study evaluated the treatment options of patients of advanced age (≥70 years) with recurrence, and survival results were analyzed. Material and Methods: The data of patients diagnosed with endometrial cancer (EC) in the Gynecological Oncology Clinic between 2001 and 2020 were evaluated retrospectively. Seventy-six cases with advanced age and relapse were evaluated. Patients who underwent hysterectomy surgery in our center and continued their follow- up regularly were included in the study. Results: The mean age at the time of recurrence was 74.6 ± 3.9 years. The endometrioid type, seen in half of the patients, was the most common histological type. Pelvic paraaortic lymph node (LN) sampling/dissection was performed in 84.2% of the patients. Deep myometrial invasion was detected in 56 (73.7%) patients, and LVSI was found in 42 (56.8%) patients. The mean time to recurrence was found to be 25.1 ± 17.8 months. Total survival times were calculated as 47.2 ± 28.2 months. The five-year overall survival (OS) rate was analyzed as 35.7%. The most common site of recurrence was lung, and isolated lung recurrence was seen in 14 (18.5%) patients. There was no significant difference for OS among patients with pelvic recurrence and extra-pelvic/multiple recurrences (p= 0.723). Conclusion: Survival outcomes in recurrences are worse in advanced- age endometrial cancer patients. This may be due to more limited treatment options for recurrence due to additional internal problems.