Browsing by Author "Kandemir, Melek"

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MANUAL AND AUTOMATIC SIZE MEASUREMENT OF LATERAL VENTRICLES AND CENTRAL SULCI AND THEIR COMPLIANCE WITH ATROPHY GRADE
(IEEE, 2015) Gokay, Gokhan; Kandemir, Melek; Tepe, M. Savas; Yalciner, Betul; Unay, Devrim
Diagnosis and treatment of various brain diseases occurring due to aging such as dementia, take an important role in contemporary research for elderly population in the world and in our country with increasing progressively. Cerebral atrophy is a feature observed in dementia patients and described as neuronal loss or cell death affecting part or all of the brain, to determine the presence and severity of atrophy, experts visually evaluate magnetic resonance images of the brain, especially at locations such as lateral ventricles and central sulci. The aim of this study is measuring the sizes (e.g. length, area and volume) of lateral ventricles and central sulci in 3D and to compare these measurements with experts' atrophy ratings. Lateral ventricle width shows high agreement (around 0.84) with atrophy grades.
Citation - WoS: 5
Citation - Scopus: 5
Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients With Forgetfulness
(Cambridge Univ Press, 2019) Yalciner, Betul Z.; Kandemir, Melek; Taskale, Sencan; Tepe, Savas M.; Unay, Devrim
Background As cognitive impairment increases with age, sulcal atrophy (SA) and the enlargement of the ventricles also increase. Considering the measurements on the previously proposed visual scales, a new scale is proposed in this study that allows us to evaluate the atrophy, white matter hyperintensities (WMHs), basal ganglia infarct (BGI), and infratentorial infarct (ITI) together. Our aim of this study is to propose a practical and standardized MRI for the clinicians to be used in daily practice. Methods A total of 97 patients older than 60 years and diagnosed with depression or Alzheimer's disease (AD) are included. Cranial MRI, Mini Mental State Examination (MMSE), detailed neuropsychometric tests, and depression scales are applied to all patients. The SA, ventricular atrophy (VA), medial temporal lobe atrophy (MTA), periventricular WMH (PWMH), subcortical WMH (SCWMH), BGI, and ITI are scored according to the scale. The total score is also recorded. Results The average age of the patients was 74.53, and the mean MMSE score was 22.7 in the degenerative group and 27.8 in the non-degenerative group. Among the patients, 50 were diagnosed with AD. All parameters significantly increased with age. In the degenerative group, SA, VA, MTA, PWMH, SCWMH, and total scores were found to be significantly higher. Sensitivities of VA, PWMH, SCWMH, and total scores, as well as both sensitivity and specificities of MTA score, were observed to be high. When they were combined, sensitivities and specificities were found to be high. Conclusion The scale is observed to be predictive in discriminating degenerative and non-degenerative processes. This discrimination is important, particularly in depressive patients complaining of forgetfulness.