Browsing by Author "Karatasli, Volkan"

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    Influence of a Hyaluronan-Binding System for Sperm Selection in Intracytoplasmic Sperm Injection Cycles on Embryo Morphokinetic Parameters and in Vitro Fertilization Cycle Outcomes
    (Springer Heidelberg, 2023) Emirdar, Volkan; Karatasli, Volkan; Tamer, Burcu; Pala, Ibrahim; Gunturkun, Fatma; Ozbaykus, Canberk; Isik, Ahmet Zeki
    PurposeAlthough the impact of the paternal contribution to embryo quality and blastocyst formation is a well-known phenomenon, the current literature provides insufficient evidence that hyaluronan-binding sperm selection methods improve assisted reproductive treatment outcomes. Thus, we compared the cycle outcomes of morphologically selected intracytoplasmic sperm injection (ICSI) with hyaluronan binding physiological intracytoplasmic sperm injection (PICSI) cycles.MethodsA total of 2415 ICSI and 400 PICSI procedures of 1630 patients who underwent in vitro fertilization cycles using a time-lapse monitoring system between 2014 and 2018 were analyzed retrospectively. Fertilization rate, embryo quality, clinical pregnancy rate, biochemical pregnancy rate and miscarriage rate were evaluated, differences in morphokinetic parameters and cycle outcomes were compared.ResultsIn total, 85.8 and 14.2% of the whole cohort were fertilized with standard ICSI and PICSI, respectively. The proportion of fertilized oocytes did not significantly differ between groups (74.53 +/- 1.33 vs. 72.92 +/- 2.64, p > 0.05). Similarly, the proportion of good-quality embryos according to the time-lapse parameters and the clinical pregnancy rate did not significantly differ between groups (71.93 +/- 4.21 vs. 71.33 +/- 2.64, p > 0.05 and 45.55 +/- 2.91 vs. 44.96 +/- 1.25, p > 0.05). No statistically significant differences were found between groups in clinical pregnancy rates (45.55 +/- 2.91 vs. 44.96 +/- 1.25, p > 0.05). Biochemical pregnancy rates (11.24 +/- 2.12 vs. 10.85 +/- 1.83, p > 0.05) and miscarriage rates (24.89 +/- 3.74 vs. 27.91 +/- 4.91, p > 0.05) were not significantly different between groups.ConclusionThe effects of the PICSI procedure on fertilization rate, biochemical pregnancy rate, miscarriage rate, embryo quality, and clinical pregnancy outcomes were not superior. The effect of the PICSI procedure on embryo morphokinetics was not apparent when all parameters were considered.
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    Perspectives and Knowledge About Fertility Preservation Strategies Among Female Cancer Patients in Turkey
    (Wiley-Hindawi, 2023) Emirdar, Volkan; Karatasli, Volkan; Acet, Ferruh; Okay, Gulin; Gode, Funda; Karabulut, Alaattin; Arslan, Cagatay
    Objectives. To evaluate the knowledge level and perspectives of female cancer patients regarding fertility preservation techniques before gonadotoxic treatment. Material and Methods. This was a prospective observational survey-based study conducted between 2016 and 2020 in Izmir Economy University Medical Park Hospital. A total of 150 female cancer patients aged 18-42 years were included. The participants completed a 17-item questionnaire, developed by the research team to evaluate their knowledge and perspectives on fertility preservation techniques. Results. The mean age of the patients was 39.5 +/- 4.9 years. Only 64.7% of the patients were referred to fertility counseling by a gynecologist, while 72.6% of the patients knew of the risk of infertility after cancer treatment. There was a significant correlation between the health status and cancer stage of the patient (p=0.003). The estimated future chance of becoming pregnant spontaneously or through fertility preservation techniques was significantly higher in patients with a higher education level (p=0.041 or 0.008, respectively). Satisfaction with the counseling process was reported as high or low by 66.7% or 20% of the patients, respectively. Conclusions. The rate of referral of reproductive-age cancer patients to fertility preservation counseling is still not satisfactory. Education level was the only variable significantly associated with a motivation to become pregnant after cancer treatment, either spontaneously or through fertility preservation techniques.