Browsing by Author "Metin, Safa Can"

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    Enhancing Two-Photon Images for Anatomical Visualisation Using Super-Resolution
    (IEEE, 2022) Aydeniz, Burhan; Metin, Safa Can; Turkan, Mehmet; Unay, Devrim; Karayannis, Theofanis; Argunsah, Ali Ozgur
    Two-photon Laser Scanning Microscopy (2P-LSM) is a technique used to image the living tissue with relatively high spatio-temporal resolution. However, the time-series images are often corrupted with Poisson-Gaussian noise and deteriorated with motion artifacts. This paper deals with the problem of enhancing 2P-LSM images to reconstruct high quality and high spatial-resolution outputs using the observed time-series stack of low-resolution images. The proposed technique consists of several components including noise filtering, image registration, cell detection and focus measurement, and clustering for a joint denoising and super-resolution. Extensive experiments demonstrate that the proposed method results in gratifying output images containing apparent and clear cell forms at different focus levels.