Browsing by Author "Okan, Taha"

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Carotis Intima-Media Thickness, Coronary Calcium Score at Different Stages of Coronary Artery Disease
(Dokuz Eylul Univ Inst Health Sciences, 2024) Okan, Taha; Doruk, Mehmet; Ozturk, Ali; Topaloglu, Caner; Yilmaz, Mehmet Birhan
Purpose: Coronary Artery Calcium Score (CACS) and Carotid Artery Intima-Media Thickness (CIMT) are surrogate markers for atherosclerosis. CACS is a recognized indicator of coronary artery disease (CAD), but CIMT's role in CAD diagnosis is debated. This study aimed to assess how well CIMT and CACS predict CAD presence and severity as detected by coronary computed tomography angiography (CCTA). Materials and Methods: In the study, 88 participants (57 CAD and 31 controls) underwent coronary angiography and CACS calculation using computerized tomography and CIMT measured according to the guidelines. Patients with CAD were classified by CACT results and further subdivided by CACS into three groups: Group I (<100), Group II (100-300), and Group III (>= 300). The relationship between CIMT and CAD groups with zero Agatston scores, as well as the control group, was also examined. Results: The CACS had 82% sensitivity and 100% specificity for predicting CAD, excluding CAD with 75.6% specificity. A CIMT max cut-off of >= 0.78 mm showed 76% sensitivity and 54% specificity for CAD. A CIMT max cut-off of >= 1.03 mm had 93% specificity but only 35% sensitivity, while <= 0.59 mm excluded CAD with 96% specificity but just 10% sensitivity. Patients with CIMT levels between 0.59 mm and 1.03 mm may need further testing to assess CAD risk accurately. Conclusion: The CACS is more sensitive than CIMT in predicting CAD, and CIMT is not helpful when the CACS is zero. Determining an optimal CIMT cutoff for CAD prediction is challenging, and patients with CIMT between 0.59 mm and 1.03 mm may require additional testing.
Coronary Artery Bypass Grafting in a Patient With Situs Inversus Totalis
(Clinics Cardive Publ Pty Ltd, 2023) Okan, Taha; Topaloğlu, Caner; Küçükk, Orhan; Bayraktaroğlu, Selen; Ceylan, Naim
Situs inversus totalis (SIT) describes a complete mirror image of the visceral organs in the thoracic and abdominal cavities. Dextrocardia, in combination with SIT, is a rare congenital anomaly with a frequency of 1:10 000, and coronary heart disease may occur with a similar frequency and manifestation as in the general population. Coronary computed tomogra-phy (CT) angiography is useful for accurately assessing the coronary artery origin and position for preprocedural plan-ning of difficult coronary artery catheterisation in SIT. In this case, invasive coronary angiography (ICA) was performed from the same angle but on the opposite side compared to standard angiography. With the use of volume-rendered three-dimensional and curved reformatted images recon-structed from coronary CT angiography, the advancement of guidewires and catheters during ICA as well as the planning of surgical procedures can be performed more safely.
Diagnostic Potential of Ctrp5 and Chemerin for Coronary Artery Disease: a Study by Coronary Computed Tomography Angiography
(Mdpi, 2025) Okan, Taha; Altin, Cihan; Topaloglu, Caner; Doruk, Mehmet; Yilmaz, Mehmet Birhan
Background/Objectives: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value of CTRP5 and chemerin in differentiating coronary computed tomography angiography (CCTA)-confirmed coronary artery disease (CAD) versus non-CAD. Secondarily, within the CCTA-confirmed CAD group, the aim was to investigate the relationship between the severity and extent of CAD, as determined by coronary artery calcium score (CACS), and the levels of CTRP5 and chemerin. Methods: Consecutive individuals with chest pain underwent CCTA to evaluate coronary artery anatomy and were divided into two groups. The CCTA-confirmed CAD group included patients with any atherosclerotic plaque (soft, mixed, or calcified) regardless of calcification, while the non-CAD group consisted of individuals without plaques on CCTA, with zero CACS, and without ischemia on stress ECG. Secondarily, in the CCTA-confirmed CAD group, the severity and extent of CAD were evaluated using CACS. Blood samples were collected and stored at -80 degrees C for analysis of CTRP5 and chemerin levels via ELISA. Results: Serum CTRP5 and chemerin levels were significantly higher in the CAD group compared to the non-CAD group (221.83 +/- 103.81 vs. 149.35 +/- 50.99 ng/mL, p = 0.003 and 105.02 +/- 35.62 vs. 86.07 +/- 19.47 ng/mL, p = 0.005, respectively). Receiver operating characteristic (ROC) analysis showed that a CTRP5 cutoff of 172.30 ng/mL had 70% sensitivity and 73% specificity for identifying CAD, while a chemerin cutoff of 90.46 ng/mL had 61% sensitivity and 62% specificity. A strong positive correlation was observed between CTRP5 and chemerin, but neither adipokine showed a correlation with the Agatston score, a measure of CAD severity and extent, nor with coronary artery stenosis as determined by CCTA. Conclusions: CTRP5 and chemerin were significantly elevated in the CCTA-confirmed CAD group compared to the non-CAD group, with CTRP5 showing greater sensitivity and specificity. However, neither adipokine was linked to CAD severity and extent, differing from findings based on invasive coronary angiography (ICA). CTRP5 may serve as a promising "all-or-none biomarker" for CAD presence.
Effect of Coronary Artery Diseases on Ocular Perfusion
(2025) Fatihoglu, Sefik Gorkem; Fatihoğlu, Özlem Ural; Topaloglu, Caner; Okan, Taha
Objectives: This study aimed to evaluate the ocular perfusion of patients with ischemic coronary artery disease (CAD) using optical coherence tomography angiography. Patients and methods: A total of 62 patients (49 male, 13 female; mean age: 62.9±9.1 years; range, 35 to 78 years) with a diagnosis of CAD were enrolled in this study. The data were compared with 61 healthy controls (35 male, 26 female; mean age: 68.1±3.9 years; range, 46 to 76 years). Coronary artery disease diagnosis was defined as patients who underwent percutaneous coronary intervention after coronary angiography. Optical coherence tomography angiography was used to assess the choroid thickness, superficial capillary plexus, and deep capillary plexus vascular density parameters of each patient. Results: Choroid thickness was lower in the CAD group compared to the control group, but this decrease was not statistically significant. The results showed a significant decrease in superficial capillary plexus and deep capillary plexus parameters in CAD patients compared to healthy controls. Conclusion: Patients with CAD showed decreased flow density compared to healthy controls. The study concludes that CAD patients exhibit reduced ocular perfusion, which can be detected using optical coherence tomography angiography. This noninvasive technique could be an effective tool for monitoring ocular perfusion and detecting vascular abnormalities in patients with CAD.
Electromechanical Demonstration of Premature Ventricular Contraction-Induced Atrial Cardiomyopathy by P Wave Duration-to-Amplitude Ratio (PWDAR) and Left Atrial Strain
(Termedia Publishing House Ltd, 2025) Dogdus, Mustafa; Okan, Taha; Taskin, Ugur; Mammadov, Ganbar; Akkaya, Bekir; Koyuncu, Ilhan; Topaloglu, Caner
Introduction: High premature ventricular contraction (PVC) burden is known to cause atrial remodeling. P wave duration-to-amplitude ratio (PWDAR) is a new P wave index that includes both P wave duration and P wave voltage, which can be considered to effectively evaluate atrial cardiomyopathy. 3D speckle-tracking echocardiography is accepted as a valid and reliable technique for assessment of the left ventricle (LV) and left atrium (LA). Aim: In the present study, we investigated whether patients with a high PVC burden exhibit subclinical left atrial electrical and mechanical dysfunction, assessed electrically using PWDAR and mechanically using 3D-speckle tracking echocardiography. Material and methods: Seventy-five patients with PVC (PVC+) and 75 age- and gender-matched controls were enrolled in the study. Surface 12-lead standard electrocardiograms (ECGs) were recorded. Clinical characteristics and laboratory values of the patients were obtained. Conventional 2D echocardiographic and 3D-STE analyses were performed. Results: The PWDAR was significantly higher in the PVC+ group than in the control group (p < 0.001); and the LAS-r, LAS-active, and LV-GLS were significantly depressed in the PVC+ group (p < 0.001, p < 0.001, p = 0.015, respectively). The multivariate regression models demonstrated that PWDAR (p < 0.001), LAS-r (p < 0.001), LAS-active (p = 0.008), and LV-GLS (p = 0.021) were independent factors predicting PVC-induced atrial cardiomyopathy (PVC-ACMP). Conclusions: Our results revealed subclinical left atrial electrical and mechanical dysfunction in patients with a high PVC burden. PWDAR and left atrial strain parameters can predict PVC-ACMP.
Citation - WoS: 10
Citation - Scopus: 10
Evaluation of Plasma Atherogenic Index, Triglyceride-Glucose Index and Other Lipid Ratios as Predictive Biomarkers of Coronary Artery Disease in Different Age Groups
(MDPI, 2024) Okan, Taha; Doruk, Mehmet; Öztürk, Ali; Topaloğlu, Caner; Doğduş, Mustafa; Yılmaz, Mehmet Birhan
(1) Background: Dyslipidaemia and insulin resistance are major risk factors for coronary artery disease (CAD). This study investigated the relationship between plasma atherogenic index (PA-I), triglyceride-glucose index (TGI) and other lipid ratios with the presence and prediction of CAD among different age categories. (2) Methods: The study included 223 participants diagnosed with CAD and those with normal coronary arteries (normal group) by coronary computed tomography angiography (CCTA). Participants were categorised by age and sex: premature CAD (PCAD) for men under 55 and women under 65, and older groups as elderly. (3) Results: PA-I, Lipid Combined Index, Castelli Risk Indices, and TGI were significantly higher in the PCAD group compared to the control group (p < 0.05). ROC analysis showed that a PA-I cut-off of 0.41 had a sensitivity of 62% and a specificity of 58% for predicting PCAD, while a TGI cut-off of 8.74 had a sensitivity of 68% and a specificity of 62%. In the elderly, no significant differences in these indices were found between the CAD and normal groups. (4) Conclusions: Traditional lipid profiles and non-traditional lipid indices such as PA-I and TGI show significant differences in predicting CAD in younger populations but not in older groups. TGI and PA-I may be promising biomarkers for the prediction of PAD, although further validation is needed.
Pentraxin 3: a Marker for the Presence and Severity of Coronary Artery Disease
(Kare Publ, 2025) Okan, Taha; Topaloglu, Caner; Altin, Cihan; Doruk, Mehmet; Yilmaz, Mehmet Birhan
Objective: Atherosclerosis, a major contributor to coronary artery disease (CAD), is characterized by chronic arterial inflammation. Pentraxin 3 (PTX-3), a biomarker of inflammation, serves as an indicator of both atherosclerosis and the progression of CAD. The aim of this study was to investigate the association between PTX-3 levels and the presence and severity of CAD, as determined by coronary computed tomography angiography (CCTA). Method: In this study, 94 participants (54 with CAD and 40 controls) underwent CCTA and coronary artery calcium scoring (CACS) using computed tomography. PTX-3 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. CAD patients were categorized based on CCTA findings and furthersubdivided into three groups according to their CACS: Group I (CACS < 100), Group II (CACS 100-299), and Group III (CACS >= 300). Results: Serum PTX-3 levels were significantly higher in the CAD group. A PTX3 cut-off value of 5.80 ng/mL predicted CAD with 68% sensitivity and 66% specificity. A strong positive correlation was observed between CACS and PTX-3 levels (r = 0.521, P < 0.001). In high-risk patients with a CACS >= 300, PTX-3 levels were significantly higher than those in low- and intermediate-risk groups a CACS < 300. However, no significant difference in PTX-3 levels was observed between the normal coronary group and the low- and intermediate-risk groups. Furthermore, no correlation was found between the degree of coronary artery stenosis and PTX-3 levels. Conclusion: Pentraxin 3 might serve as a valuable biomarkerforthe diagnosis and severity of CAD.