Browsing by Author "Onal, Tuna"

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Effect of Pacap (pituitary Adenylate Cyclase Activating Polypeptide) and Its Receptor on Oocyte in Vitro Maturation
(Wiley, 2019) Temel, Merve; Onal, Tuna; Bilgin, Muge; Oztatlici, Mustafa; Vatansever, Seda Hafize; Inan, Sevinc; Ozbilgin, Kemal Mahmut
[Abstract Not Available]
Citation - WoS: 1
Citation - Scopus: 1
Histologic and Physiologic Analysis of the Relationship Between the Dorsal Nerve of the Penis and the Corpus Cavernosum on a Rat Model. a Complementary Pathway on the Innervation of Penile Erection?
(Wiley, 2022) Kozacıoğlu, Zafer; Vatansever, H. Seda; Onal, Tuna; Kutlu, Necip; Ozel, Fehmi; Gunlusoy, Bulent; Gumus, Bilal H.
Aim The dorsal nerve of the penis (DNP) is the terminal branch of the pudendal nerve which is responsible for the somatic innervation of the penis. This study aims to outline any direct role of the DNP in the hemodynamics of erection histologically and physiologically. Materials and Methods Fifteen Wistar albino rats were sorted into the electrical activity (n = 6), intracavernous pressure (n = 4), and control (n = 5) groups. The dorsal nerve was electrostimulated and the simultaneous changes in intracavernous pressure and smooth muscle activity were recorded. Penile tissues were collected, fixed, and sectioned, the slides were stained with either hematoxylin-eosin for morphological evaluation or using the indirect immunoperoxidase technique to analyze the distributions of eNOS, iNOS, and nNOS. Results During electrostimulation, there was a simultaneous statistically significant decrease in the electrical activity inside the corpora in electromyography and an increase in intracavernous pressure. eNOS and iNOS immunoreactivities were higher in the study group than in the control group. nNOS immunoreactivity was moderate in both study and control groups. Conclusion Some fibers in the dorsal nerve of penis continue into the corpora cavernosa through the tunica albuginea and have an active, direct role in the hemodynamic process of erection, which may be complementary to the main route of innervation.
Citation - WoS: 4
Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement
(Duzce Univ, 2019) Cesur, Mine Gecgelen; Onal, Tuna; Bilgin, Mehmet Dincer; Sirin, Fevziye Burcu; Inan, Sevinc; Koken, Ergun Cem; Alkan, Afra
Objective: The goal of our study is to assess the effects of low intensity pulsed ultrasound on orthodontic tooth movement in rats. Methods: For this study, 40 adult male Wistar albino rats (12-weeks old age) were used from the Animal Laboratory at Adnan Menderes University. Rats were divided into four groups each of ten. Group 1 was the untreated as a control. In group 2, an orthodontic spring was used to move teeth. For groups 3 and 4, orthodontic treatment was combined with low intensity pulsed ultrasound at 16 J/cm2 or 48 J/cm2 for 14 days, respectively. Tooth movement was measured at the last day of treatment. Serum bone alkaline phosphatase (BALP) and C-telopeptide type I collagen (CTX-I) levels were analyzed biochemically. The number of osteoclasts, osteoblasts and inflammatory cells, capillary density and new bone formation was determined histologically. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) were assessed using immunohistochemical staining. Results: BALP and CTX-I levels in group 4 were significantly higher compared to control (p<0.05). Tooth movement and the number of osteoclasts, inflammatory cells and capillary density in group 4 were significantly greater than group 2 (p<0.05). The intensity levels of RANKL and OPG in group 4 were significantly greater than group 2 (p<0.05). Conclusions: Ultrasound is a noninvasive application and promising therapy for accelerating bone remodelling during orthodontic tooth movement.
Citation - WoS: 5
Influence of Omega-3 Fatty Acid on Orthodontic Tooth Movement in Rats: a Biochemical, Histological, Immunohistochemical and Gene Expression Study
(Wiley, 2019) Ogrenim, Gozde; Cesur, Mine G.; Onal, Tuna; Kara, Murat; Sirin, Fevziye B.; Yalcin, Gizem D.; Inan, Sevinc
Structured Abstract Objective The aim of this study was to investigate the effects of omega-3 fatty acids on orthodontic tooth movement. Setting and Sample Population For this study, 56 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. Material and Methods Rats were randomly divided into seven groups (n = 8 each): control group (without any treatment), tooth movement groups (three groups of animals with only tooth movement) and omega groups (three groups of animals with tooth movement and omega-3 administration). Omega-3 fatty acids were administered to the rats systemically during the tooth movement period. On the 3rd, 7th and 14th days after the orthodontic tooth movement, the rats were sacrificed and biochemical, histological, immunohistochemical andgene expression examinations were performed. Results On the 14th experimental day, the amount of tooth movement in the omega groups was significantly lower than the tooth movement groups (P = 0.012). Biochemical experimentsshowed that the omega groups had significantly lower total oxidant levels and higher total antioxidant levels compared to the tooth movement group on the 14th experimental day (P = 0.001). The levels of RANKL, IL-6 and IL-1 beta in the omega groups were significantly lower than the tooth movement groups on all experimental days (P < 0.05). Conclusion Systemic administration of omega-3 fatty acids showed antioxidant and antiinflammatory effects and decelerate the orthodontic tooth movement.