Browsing by Author "Ozdemir, E."

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    Adrenomedullin Has No Effect on Segmental Bone Defect Healing but Increases Bone Mineral Density in Rat Model
    (AVES, 2023) Kaymakoğlu, Mehmet; Ciftci, E.; Korkusuz, P.; Ozdemir, E.; Erden, M.E.; Turhan, E.
    Objective: This study aimed to investigate the effect of adrenomedullin on the healing of the segmental bone defect in a rat model. Methods: Thirty-six Wistar rats were randomly divided into 6 groups based on follow-up periods and administered a dose of adreno-medullin hormone. In each group, bilaterally, a 2-mm bone defect was created at the diaphysis of the radius. Sodium chloride solution was administered to sham groups 3 times a week for 4 and 8 weeks intraperitoneally. Adrenomedullin was administered to the study groups 3 times a week: 15 μg—4 weeks, 15 μg—8 weeks, 30 μg—4 weeks, and 30 μg—8 weeks, respectively. After euthanasia, the segmental defects were evaluated by histomorphometric [new bone area (NBA)] and microtomographic [bone volume (BV), bone surface (BS), and bone mineral density (BMD)] analyses. Results: Although the 4-and 8-week 15 μg administered study groups had higher NBA values than the other study and control groups, the histomorphometric analysis did not reveal any statistical difference between the control and study groups regarding NBA (P >.05). In microtomographic analysis, BV was higher in the 15 μg 4-week group than 30 μg 4-week group (296.9 vs. 208.5, P =.003), and BS was lower in the 30 μg 4-week group than in the 4-week control group (695.5 vs. 1334.7, P =.005), but overall, no significant difference was found between the control and study groups (P >.05). Despite these minor differences in histomorphometric and microtomographic criteria indicating new bone formation, the BMD values of the 15 μg 8-week study group showed a significant increase compared with the control group (P =.001, respectively). Conclusion: Adrenomedullin positively affected BMD at 15 μg, but this study could not show healing in the segmental defect site at different dose regimens. Further studies are needed to assess its effects on bone tissue trauma. © 2023, AVES. All rights reserved.
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    Source-Dependent Quality Variation in Shoulder Dislocation Videos on Youtube
    (Elsevier Inc., 2024) Kaymakoğlu, Mehmet; Aksoy, T.; Kolac, U.C.; Ozdemir, E.; DePhillipo, N.N.; Huri, G.; Familiari, F.
    Purpose: To assess the quality of YouTube videos for patient education on shoulder dislocation. Methods: A standard YouTube search was performed in March 2023 using the terms “shoulder dislocation,” “dislocated shoulder,” and “glenohumeral joint dislocation” to identify eligible videos. Multiple scoring systems, including DISCERN (a validated tool for analyzing the quality of health information in consumer-targeted videos), Journal of the American Medical Association (JAMA) Benchmark Criteria, and the Global Quality Score (GQS) were used to evaluate the videos. Video quality scores from various sources were compared using the Kruskal-Wallis test for initial analysis, followed by Dunn's post-hoc test with Bonferroni correction, and the strength of relationship between variables was assessed using Spearman's rank correlation coefficient. Results: A total of 162 eligible videos were identified. The mean video duration was 11.38 ± 3.01 minutes, the median number of views was 653. Median number of days since upload was 1,972, the median view rate was 0.343, and median number of likes was 66.12. Based on the DISCERN classification, a substantial proportion of videos were classified as insufficient quality, with 19.4% as “very insufficient” and 42.1% as “insufficient”; 24.1% were classified as “average” quality, whereas only 13.1% were classified as “good” and 1.2% were “excellent.” Videos from academic and professional sources showed a significant positive correlation with DISCERN scores (rho: +0.784, P < .001) and greater scores on all 4 scoring systems compared to health information websites. Conclusions: This study reveals that the majority of YouTube videos on shoulder dislocation lack sufficient quality for patient education, with content quality significantly influenced by the source. Clinical Relevance: Examining the accuracy of information that patients encounter on YouTube is essential for health care providers to direct individuals toward more reliable sources of information. © 2024 The Authors