Browsing by Author "Pala, Ibrahim"

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    Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Comparison of the Effects of Piezoelectric and Calcium Ionophore Activation on Fertilization and Blastulation Rates of Sibling Oocytes
    (Taylor & Francis Ltd, 2025) Gode, Funda; Pala, Ibrahim; Yildirim, Fatma; Abdi, Zahra
    To determine rates of fertilization, good-quality day 3 embryos, and blastocyst progression in sibling oocytes of the same patients undergoing piezo and calcium ionophore (CaI) activation. The retrospective cohort study included couples undergoing assisted reproductive treatment in 2023-2024 for primary infertility with a history of low fertilization rates (<30%), low blastulation rates (<20%), or male factor infertility such as teratozoospermia at the Izmir University of Economics Medical Point Hospital IVF Center. Sibling oocytes from each patient were randomly assigned to piezoelectric or CaI activation. The fertilization rate, number of degenerated embryos, number of abnormally fertilized eggs, number of day 3 grade 1 embryos, and blastocyst counts were compared among the sibling oocytes. In total, 1,105 MII sibling oocytes from 76 patients were included. Piezoelectric activation was applied to 575 MII oocytes, while CaI activation was applied to 530 MII oocytes. There was no significant difference between groups according to the activation method in the fertilization rate (piezo, 0.74% +/- 0.22%; CaI, 0.68% +/- 0.26%, p = 0.12), degeneration rate (piezo, 0.04% +/- 0.13%; CaI, 0.02% +/- 0.06%, p = 0.452), day 3 grade 1 embryo rate (piezo, 0.59% +/- 0.33%; CaI, 0.54% +/- 0.35%, p = 0.34), or blastocyst rate (piezo, 0.49% +/- 0.33%; CaI, 0.43% +/- 0.34%, p = 0.28) of sibling oocytes. Both piezoelectric and CaI activation yielded comparable results in terms of oocyte activation, with similar fertilization and blastulation rates.
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    Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Influence of a Hyaluronan-Binding System for Sperm Selection in Intracytoplasmic Sperm Injection Cycles on Embryo Morphokinetic Parameters and in Vitro Fertilization Cycle Outcomes
    (Springer Heidelberg, 2023) Emirdar, Volkan; Karatasli, Volkan; Tamer, Burcu; Pala, Ibrahim; Gunturkun, Fatma; Ozbaykus, Canberk; Isik, Ahmet Zeki
    PurposeAlthough the impact of the paternal contribution to embryo quality and blastocyst formation is a well-known phenomenon, the current literature provides insufficient evidence that hyaluronan-binding sperm selection methods improve assisted reproductive treatment outcomes. Thus, we compared the cycle outcomes of morphologically selected intracytoplasmic sperm injection (ICSI) with hyaluronan binding physiological intracytoplasmic sperm injection (PICSI) cycles.MethodsA total of 2415 ICSI and 400 PICSI procedures of 1630 patients who underwent in vitro fertilization cycles using a time-lapse monitoring system between 2014 and 2018 were analyzed retrospectively. Fertilization rate, embryo quality, clinical pregnancy rate, biochemical pregnancy rate and miscarriage rate were evaluated, differences in morphokinetic parameters and cycle outcomes were compared.ResultsIn total, 85.8 and 14.2% of the whole cohort were fertilized with standard ICSI and PICSI, respectively. The proportion of fertilized oocytes did not significantly differ between groups (74.53 +/- 1.33 vs. 72.92 +/- 2.64, p > 0.05). Similarly, the proportion of good-quality embryos according to the time-lapse parameters and the clinical pregnancy rate did not significantly differ between groups (71.93 +/- 4.21 vs. 71.33 +/- 2.64, p > 0.05 and 45.55 +/- 2.91 vs. 44.96 +/- 1.25, p > 0.05). No statistically significant differences were found between groups in clinical pregnancy rates (45.55 +/- 2.91 vs. 44.96 +/- 1.25, p > 0.05). Biochemical pregnancy rates (11.24 +/- 2.12 vs. 10.85 +/- 1.83, p > 0.05) and miscarriage rates (24.89 +/- 3.74 vs. 27.91 +/- 4.91, p > 0.05) were not significantly different between groups.ConclusionThe effects of the PICSI procedure on fertilization rate, biochemical pregnancy rate, miscarriage rate, embryo quality, and clinical pregnancy outcomes were not superior. The effect of the PICSI procedure on embryo morphokinetics was not apparent when all parameters were considered.
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    Conference Object
    Novel Tool for Endonietrial Assessment in Embryo Transfer Cycles: Endometrial Elastograpry.
    (Elsevier Science Inc, 2022) Emirdar, Volkan; Gode, Funda; Pala, Ibrahim; Sahin, Erkan
    [Abstract Not Available]